Abstract
In myxoid/round cell liposarcoma, the t(12;16)(q13; p11) and its associated fusion transcript, FUS-CHOP, characterize greater than 95% of cases. The variant translocation t(12;22)(q13;q12) and associated EWS-CHOP fusion transcript are rare. A second non-random aberration observed in roughly 20% of Ewing's sarcomas, and to a lesser extent other select sarcomas, is the unbalanced 1;16 translocation. Recognition of this secondary aberration in the absence of an obvious primary karyotypic abnormality strongly suggests that the use of other genetic approaches will be informative in uncovering a clinically suspected primary anomaly. The following case illustrates the utility of molecular cytogenetic and reverse transcriptase-polymerase chain reaction techniques in diagnosing an ins(22;12)(q12;q13q14) and associated EWS-CHOP fusion transcript in a myxoid/round cell liposarcoma exhibiting a der(16)t(1;16)(q11;q11).
Original language | English (US) |
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Pages (from-to) | 191-194 |
Number of pages | 4 |
Journal | Journal of Molecular Diagnostics |
Volume | 5 |
Issue number | 3 |
DOIs | |
State | Published - Aug 2003 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Pathology and Forensic Medicine
- Molecular Medicine