Increased expression of ampC in Pseudomonas aeruginosa mutants selected with ciprofloxacin

Daniel J. Wolter, Amber J. Schmidtke, Nancy D. Hanson, Philip D. Lister

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Two Pseudomonas aeruginosa mutants exhibiting increased expression of ampC were selected during exposure to ciprofloxacin. These mutants also exhibited significant increases in mexCD-oprJ expression, but further studies failed to show a link between the increased expression of mexCD-oprJ and ampC. Increased ampC expression was not related to mutations within ampR, the ampC-ampR intergenic region, ampD, ampDh2, or ampDh3 or to changes in the levels of expression of these amidase genes. However, ampD complementation restored wild-type levels of ampC expression and ceftazidime susceptibility, suggesting alternative mechanisms of ampC regulation.

Original languageEnglish (US)
Pages (from-to)2997-3000
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume51
Issue number8
DOIs
StatePublished - Aug 1 2007

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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