Abstract
T-antigen expression in 24 of 31 skin fibroblast cell lines from members of Family G was found to be significantly elevated compared with a healthy control population. However, the pattern of elevation did not appear to be associated with cancer risk. In addition, T-antigen values were independent of the age and sex, as well as the branch of family and generation of the cell donor. Cell lines from Family G tended to divide more frequently than cell lines from control donors. This tendency was negatively associated with elevated T-antigen expression in Family-G cell lines, while control cell lines showed no such correlation. These results demonstrate that caution must be taken in evaluating potential markers of cancer risk. Superficial analysis of the data would indicate the utility of the T-antigen assay as a marker for cancer family syndrome. However, consideration of additional factors, including pedigree relationships and cell biology in vitro, indicate that SV40 T-antigen expression is an ambiguous marker of this type of cancer risk, even when large groups are studied.
| Original language | English |
|---|---|
| Pages (from-to) | 127-133 |
| Number of pages | 7 |
| Journal | Journal of Cancer Research and Clinical Oncology |
| Volume | 103 |
| Issue number | 2 |
| DOIs | |
| State | Published - May 1982 |
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All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research
Cite this
Increased expression of SV40 T antigen and cell division in skin fibroblast cell lines derived from a family at high risk of carcinoma (Family G of warthin). / Lubiniecki, Anthony S.; Lynch, Henry T.; Blattner, William A.; Guirgis, Hoda.
In: Journal of Cancer Research and Clinical Oncology, Vol. 103, No. 2, 05.1982, p. 127-133.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Increased expression of SV40 T antigen and cell division in skin fibroblast cell lines derived from a family at high risk of carcinoma (Family G of warthin)
AU - Lubiniecki, Anthony S.
AU - Lynch, Henry T.
AU - Blattner, William A.
AU - Guirgis, Hoda
PY - 1982/5
Y1 - 1982/5
N2 - T-antigen expression in 24 of 31 skin fibroblast cell lines from members of Family G was found to be significantly elevated compared with a healthy control population. However, the pattern of elevation did not appear to be associated with cancer risk. In addition, T-antigen values were independent of the age and sex, as well as the branch of family and generation of the cell donor. Cell lines from Family G tended to divide more frequently than cell lines from control donors. This tendency was negatively associated with elevated T-antigen expression in Family-G cell lines, while control cell lines showed no such correlation. These results demonstrate that caution must be taken in evaluating potential markers of cancer risk. Superficial analysis of the data would indicate the utility of the T-antigen assay as a marker for cancer family syndrome. However, consideration of additional factors, including pedigree relationships and cell biology in vitro, indicate that SV40 T-antigen expression is an ambiguous marker of this type of cancer risk, even when large groups are studied.
AB - T-antigen expression in 24 of 31 skin fibroblast cell lines from members of Family G was found to be significantly elevated compared with a healthy control population. However, the pattern of elevation did not appear to be associated with cancer risk. In addition, T-antigen values were independent of the age and sex, as well as the branch of family and generation of the cell donor. Cell lines from Family G tended to divide more frequently than cell lines from control donors. This tendency was negatively associated with elevated T-antigen expression in Family-G cell lines, while control cell lines showed no such correlation. These results demonstrate that caution must be taken in evaluating potential markers of cancer risk. Superficial analysis of the data would indicate the utility of the T-antigen assay as a marker for cancer family syndrome. However, consideration of additional factors, including pedigree relationships and cell biology in vitro, indicate that SV40 T-antigen expression is an ambiguous marker of this type of cancer risk, even when large groups are studied.
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UR - http://www.scopus.com/inward/citedby.url?scp=0020029299&partnerID=8YFLogxK
U2 - 10.1007/BF00409643
DO - 10.1007/BF00409643
M3 - Article
VL - 103
SP - 127
EP - 133
JO - Journal of Cancer Research and Clinical Oncology
JF - Journal of Cancer Research and Clinical Oncology
SN - 0171-5216
IS - 2
ER -