Increased incidence of hip fracture in osteoporotic women treated with sodium fluoride

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Abstract

There has been controversy as to whether fluoride therapy increases the risk of fracture in the appendicular skeleton. In the present study we compared the incidence of hip fracture in four groups of osteoporotic women: 22 treated with placebo, 17 with fluoride and calcium, 18 treated with fluoride and calcitriol, and 21 with calcitriol alone. Four hip fractures occurred in 3 patients on fluoride and calcitriol, and two hip fractures occurred in 2 patients on fluoride and calcium. No hip fractures occurred in patients receiving either calcitriol alone or placebo. The difference in fracture rates for fluoride versus nonfluoride treatment is significant (p = 0.006). Moreover, the six hip fractures occurring in patients receiving fluoride during 72.3 patient years of treatment is 10 times higher than would be expected in normal women of the same age. The probability of observing six fractures in 2 years is extremely small (0.0003). In four of the hip fracture cases, the history suggested a spontaneous fracture. These findings suggest that fluoride treatment can increase the risk of hip fracture in osteoporotic women.

Original languageEnglish
Pages (from-to)223-225
Number of pages3
JournalJournal of Bone and Mineral Research
Volume4
Issue number2
StatePublished - 1989

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Sodium Fluoride
Hip Fractures
Fluorides
Calcitriol
Incidence
Calcium Fluoride
Placebos
Spontaneous Fractures
Therapeutics
Skeleton
Cohort Studies
History

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Increased incidence of hip fracture in osteoporotic women treated with sodium fluoride. / Hedlund, L. R.; Gallagher, John Christopher G.

In: Journal of Bone and Mineral Research, Vol. 4, No. 2, 1989, p. 223-225.

Research output: Contribution to journalArticle

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