Indole-2-carboxamides are active against mycobacterium abscessus in a mouse model of acute infection

Amit N. Pandya, Pavan K. Prathipati, Pooja Hegde, Wei Li, Kyle F. Graham, Subhra Mandal, Kristen M. Drescher, Christopher J. Destache, Diane Ordway, Mary Jackson, E. Jeffrey Northa

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Abstract

Nontuberculous mycobacteria (NTM) pathogens particularly infect patients with structural lung disorders. We previously reported novel indole-2-carboxamides (ICs) that are active against a wide panel of NTM pathogens. This study discloses in vivo data for two lead molecules (compounds 5 and 25) that were advanced for efficacy studies in Mycobacterium abscessus-infected mouse models. Oral administration of the lead molecules showed a statistically significant reduction in the bacterial loads in lung and spleen of M. abscessus-infected mice.

Original languageEnglish (US)
Article numbere02245-18
JournalAntimicrobial Agents and Chemotherapy
DOIs
StatePublished - Mar 1 2019

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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    Pandya, A. N., Prathipati, P. K., Hegde, P., Li, W., Graham, K. F., Mandal, S., Drescher, K. M., Destache, C. J., Ordway, D., Jackson, M., & Northa, E. J. (2019). Indole-2-carboxamides are active against mycobacterium abscessus in a mouse model of acute infection. Antimicrobial Agents and Chemotherapy, [e02245-18]. https://doi.org/10.1128/AAC.02245-18