Indole-2-carboxamides are active against mycobacterium abscessus in a mouse model of acute infection

Amit N. Pandya, Pavan K. Prathipati, Pooja Hegde, Wei Li, Kyle F. Graham, Subhra Mandal, Kristen M. Drescher, Christopher J. Destache, Diane Ordway, Mary Jackson, E. Jeffrey Northa

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Nontuberculous mycobacteria (NTM) pathogens particularly infect patients with structural lung disorders. We previously reported novel indole-2-carboxamides (ICs) that are active against a wide panel of NTM pathogens. This study discloses in vivo data for two lead molecules (compounds 5 and 25) that were advanced for efficacy studies in Mycobacterium abscessus-infected mouse models. Oral administration of the lead molecules showed a statistically significant reduction in the bacterial loads in lung and spleen of M. abscessus-infected mice.

Original languageEnglish (US)
Article numbere02245-18
JournalAntimicrobial Agents and Chemotherapy
DOIs
StatePublished - Mar 1 2019

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Nontuberculous Mycobacteria
Mycobacterium
Lung
Bacterial Load
Infection
Oral Administration
Spleen
indole

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Pandya, A. N., Prathipati, P. K., Hegde, P., Li, W., Graham, K. F., Mandal, S., ... Northa, E. J. (2019). Indole-2-carboxamides are active against mycobacterium abscessus in a mouse model of acute infection. Antimicrobial Agents and Chemotherapy, [e02245-18]. https://doi.org/10.1128/AAC.02245-18

Indole-2-carboxamides are active against mycobacterium abscessus in a mouse model of acute infection. / Pandya, Amit N.; Prathipati, Pavan K.; Hegde, Pooja; Li, Wei; Graham, Kyle F.; Mandal, Subhra; Drescher, Kristen M.; Destache, Christopher J.; Ordway, Diane; Jackson, Mary; Northa, E. Jeffrey.

In: Antimicrobial Agents and Chemotherapy, 01.03.2019.

Research output: Contribution to journalArticle

Pandya, Amit N. ; Prathipati, Pavan K. ; Hegde, Pooja ; Li, Wei ; Graham, Kyle F. ; Mandal, Subhra ; Drescher, Kristen M. ; Destache, Christopher J. ; Ordway, Diane ; Jackson, Mary ; Northa, E. Jeffrey. / Indole-2-carboxamides are active against mycobacterium abscessus in a mouse model of acute infection. In: Antimicrobial Agents and Chemotherapy. 2019.
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AU - Jackson, Mary

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