Influence of Left Ventricular Hypertrophy on In-Hospital Outcomes in Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Saraschandra Vallabhajosyula, Pranathi R. Sundaragiri, Arun Kanmanthareddy, Anas A. Ahmed, Toufik Mahfood Haddad, Hamza AA Rayes, Anila N. Khan, Haitam M. Buaisha, Gene E. Pershwitz, Dustin A. McCann, Mark Jeffrey Holmberg, Lee E. Morrow

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Abstract

Left ventricular hypertrophy (LVH) is associated with worse outcomes in chronic obstructive pulmonary disease (COPD); however, its role in an acute exacerbation of COPD (AECOPD) has not been reported. This was a retrospective cohort study during 2008–2012 at an academic medical center. AECOPD patients >18 years with available echocardiographic data were included. LVH was defined as LV mass index (LVMI) >95 g/m2 (women) and >115g/m2 (men). Relative wall thickness was used to classify LVH as concentric (>0.42) or eccentric (2 vs. 79.7 ± 19.1 g/m2; p <0.001) and lower LV ejection fraction (44.5±21.9% vs. 50.0±21.6%; p ≤ 0.001). The LVH cohort had statistically non-significant longer ICU LOS, and higher NIV and MV use and duration. Of the 264 LVH patients, concentric LVH (198; 75.0%) was predictive of greater NIV use [82 (41.4%) vs. 16 (24.2%), p = 0.01] and duration (1.0 ± 1.9 vs. 0.6 ± 1.4 days, p = 0.01) compared to eccentric LVH. Concentric LVH remained independently associated with NIV use and duration. In-hospital outcomes in patients with AECOPD were comparable in patients with and without LVH. Patients with concentric LVH had higher NIV need and duration in comparison to eccentric LVH.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalCOPD: Journal of Chronic Obstructive Pulmonary Disease
DOIs
StateAccepted/In press - Jun 27 2016

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Left Ventricular Hypertrophy
Chronic Obstructive Pulmonary Disease
Cohort Studies
Retrospective Studies

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

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Influence of Left Ventricular Hypertrophy on In-Hospital Outcomes in Acute Exacerbation of Chronic Obstructive Pulmonary Disease. / Vallabhajosyula, Saraschandra; Sundaragiri, Pranathi R.; Kanmanthareddy, Arun; Ahmed, Anas A.; Mahfood Haddad, Toufik; Rayes, Hamza AA; Khan, Anila N.; Buaisha, Haitam M.; Pershwitz, Gene E.; McCann, Dustin A.; Holmberg, Mark Jeffrey; Morrow, Lee E.

In: COPD: Journal of Chronic Obstructive Pulmonary Disease, 27.06.2016, p. 1-6.

Research output: Contribution to journalArticle

Vallabhajosyula, Saraschandra ; Sundaragiri, Pranathi R. ; Kanmanthareddy, Arun ; Ahmed, Anas A. ; Mahfood Haddad, Toufik ; Rayes, Hamza AA ; Khan, Anila N. ; Buaisha, Haitam M. ; Pershwitz, Gene E. ; McCann, Dustin A. ; Holmberg, Mark Jeffrey ; Morrow, Lee E. / Influence of Left Ventricular Hypertrophy on In-Hospital Outcomes in Acute Exacerbation of Chronic Obstructive Pulmonary Disease. In: COPD: Journal of Chronic Obstructive Pulmonary Disease. 2016 ; pp. 1-6.
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AU - Khan, Anila N.

AU - Buaisha, Haitam M.

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AB - Left ventricular hypertrophy (LVH) is associated with worse outcomes in chronic obstructive pulmonary disease (COPD); however, its role in an acute exacerbation of COPD (AECOPD) has not been reported. This was a retrospective cohort study during 2008–2012 at an academic medical center. AECOPD patients >18 years with available echocardiographic data were included. LVH was defined as LV mass index (LVMI) >95 g/m2 (women) and >115g/m2 (men). Relative wall thickness was used to classify LVH as concentric (>0.42) or eccentric (2 vs. 79.7 ± 19.1 g/m2; p <0.001) and lower LV ejection fraction (44.5±21.9% vs. 50.0±21.6%; p ≤ 0.001). The LVH cohort had statistically non-significant longer ICU LOS, and higher NIV and MV use and duration. Of the 264 LVH patients, concentric LVH (198; 75.0%) was predictive of greater NIV use [82 (41.4%) vs. 16 (24.2%), p = 0.01] and duration (1.0 ± 1.9 vs. 0.6 ± 1.4 days, p = 0.01) compared to eccentric LVH. Concentric LVH remained independently associated with NIV use and duration. In-hospital outcomes in patients with AECOPD were comparable in patients with and without LVH. Patients with concentric LVH had higher NIV need and duration in comparison to eccentric LVH.

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