Influence of Left Ventricular Hypertrophy on In-Hospital Outcomes in Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Saraschandra Vallabhajosyula, Pranathi R. Sundaragiri, Arun Kanmanthareddy, Anas A. Ahmed, Toufik Mahfood Haddad, Hamza A.A. Rayes, Anila N. Khan, Haitam M. Buaisha, Gene E. Pershwitz, Dustin A. McCann, Mark J. Holmberg, Lee E. Morrow

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Left ventricular hypertrophy (LVH) is associated with worse outcomes in chronic obstructive pulmonary disease (COPD); however, its role in an acute exacerbation of COPD (AECOPD) has not been reported. This was a retrospective cohort study during 2008–2012 at an academic medical center. AECOPD patients >18 years with available echocardiographic data were included. LVH was defined as LV mass index (LVMI) >95 g/m2 (women) and >115g/m2 (men). Relative wall thickness was used to classify LVH as concentric (>0.42) or eccentric (2 vs. 79.7 ± 19.1 g/m2; p <0.001) and lower LV ejection fraction (44.5±21.9% vs. 50.0±21.6%; p ≤ 0.001). The LVH cohort had statistically non-significant longer ICU LOS, and higher NIV and MV use and duration. Of the 264 LVH patients, concentric LVH (198; 75.0%) was predictive of greater NIV use [82 (41.4%) vs. 16 (24.2%), p = 0.01] and duration (1.0 ± 1.9 vs. 0.6 ± 1.4 days, p = 0.01) compared to eccentric LVH. Concentric LVH remained independently associated with NIV use and duration. In-hospital outcomes in patients with AECOPD were comparable in patients with and without LVH. Patients with concentric LVH had higher NIV need and duration in comparison to eccentric LVH.

Original languageEnglish (US)
Pages (from-to)712-717
Number of pages6
JournalCOPD: Journal of Chronic Obstructive Pulmonary Disease
Issue number6
StatePublished - Nov 1 2016


All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

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