Inhaled voriconazole for prevention of invasive pulmonary aspergillosis

Justin Tolman, Nathan P. Wiederhold, Jason T. McConville, Laura K. Najvar, Rosie Bocanegra, Jay I. Peters, Jacqueline J. Coalson, John R. Graybill, Thomas F. Patterson, Robert O. Williams

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Targeted airway delivery of antifungals as prophylaxis against invasive aspergillosis may lead to high lung drug concentrations while avoiding toxicities associated with systemically administered agents. We evaluated the effectiveness of aerosolizing the intravenous formulation of voriconazole as prophylaxis against invasive pulmonary aspergillosis caused by Aspergillus fumigatus in an established murine model. Inhaled voriconazole significantly improved survival and limited the extent of invasive disease, as assessed by histopathology, compared to control and amphotericin B treatments.

Original languageEnglish
Pages (from-to)2613-2615
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume53
Issue number6
DOIs
StatePublished - Jun 2009
Externally publishedYes

Fingerprint

Invasive Pulmonary Aspergillosis
Aspergillus fumigatus
Aspergillosis
Amphotericin B
Lung
Pharmaceutical Preparations
Voriconazole

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

Cite this

Tolman, J., Wiederhold, N. P., McConville, J. T., Najvar, L. K., Bocanegra, R., Peters, J. I., ... Williams, R. O. (2009). Inhaled voriconazole for prevention of invasive pulmonary aspergillosis. Antimicrobial Agents and Chemotherapy, 53(6), 2613-2615. https://doi.org/10.1128/AAC.01657-08

Inhaled voriconazole for prevention of invasive pulmonary aspergillosis. / Tolman, Justin; Wiederhold, Nathan P.; McConville, Jason T.; Najvar, Laura K.; Bocanegra, Rosie; Peters, Jay I.; Coalson, Jacqueline J.; Graybill, John R.; Patterson, Thomas F.; Williams, Robert O.

In: Antimicrobial Agents and Chemotherapy, Vol. 53, No. 6, 06.2009, p. 2613-2615.

Research output: Contribution to journalArticle

Tolman, J, Wiederhold, NP, McConville, JT, Najvar, LK, Bocanegra, R, Peters, JI, Coalson, JJ, Graybill, JR, Patterson, TF & Williams, RO 2009, 'Inhaled voriconazole for prevention of invasive pulmonary aspergillosis', Antimicrobial Agents and Chemotherapy, vol. 53, no. 6, pp. 2613-2615. https://doi.org/10.1128/AAC.01657-08
Tolman J, Wiederhold NP, McConville JT, Najvar LK, Bocanegra R, Peters JI et al. Inhaled voriconazole for prevention of invasive pulmonary aspergillosis. Antimicrobial Agents and Chemotherapy. 2009 Jun;53(6):2613-2615. https://doi.org/10.1128/AAC.01657-08
Tolman, Justin ; Wiederhold, Nathan P. ; McConville, Jason T. ; Najvar, Laura K. ; Bocanegra, Rosie ; Peters, Jay I. ; Coalson, Jacqueline J. ; Graybill, John R. ; Patterson, Thomas F. ; Williams, Robert O. / Inhaled voriconazole for prevention of invasive pulmonary aspergillosis. In: Antimicrobial Agents and Chemotherapy. 2009 ; Vol. 53, No. 6. pp. 2613-2615.
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