Inhaled voriconazole for prevention of invasive pulmonary aspergillosis

Justin A. Tolman, Nathan P. Wiederhold, Jason T. McConville, Laura K. Najvar, Rosie Bocanegra, Jay I. Peters, Jacqueline J. Coalson, John R. Graybill, Thomas F. Patterson, Robert O. Williams

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Targeted airway delivery of antifungals as prophylaxis against invasive aspergillosis may lead to high lung drug concentrations while avoiding toxicities associated with systemically administered agents. We evaluated the effectiveness of aerosolizing the intravenous formulation of voriconazole as prophylaxis against invasive pulmonary aspergillosis caused by Aspergillus fumigatus in an established murine model. Inhaled voriconazole significantly improved survival and limited the extent of invasive disease, as assessed by histopathology, compared to control and amphotericin B treatments.

Original languageEnglish (US)
Pages (from-to)2613-2615
Number of pages3
JournalAntimicrobial agents and chemotherapy
Issue number6
StatePublished - Jun 2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases


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