Inherited genetic susceptibility to multiple myeloma

G. J. Morgan, D. C. Johnson, N. Weinhold, H. Goldschmidt, O. Landgren, Henry T. Lynch, K. Hemminki, R. S. Houlston

Research output: Contribution to journalReview article

34 Citations (Scopus)

Abstract

Although the familial clustering of multiple myeloma (MM) supports the role of inherited susceptibility, only recently has direct evidence for genetic predisposition been demonstrated. A meta-analysis of two genome-wide association (GWA) studies has identified single-nucleotide polymorphisms (SNPs) localising to a number of genomic regions that are robustly associated with MM risk. In this review, we provide an overview of the evidence supporting a genetic contribution to the predisposition to MM and MGUS (monoclonal gammopathy of unknown significance), and the insight this gives into the biological basis of disease aetiology. We also highlight the promise of future approaches to identify further specific risk factors and their potential clinical utility.

Original languageEnglish
Pages (from-to)518-524
Number of pages7
JournalLeukemia
Volume28
Issue number3
DOIs
StatePublished - 2014

Fingerprint

Genetic Predisposition to Disease
Multiple Myeloma
Paraproteinemias
Genome-Wide Association Study
Single Nucleotide Polymorphism
Cluster Analysis
Meta-Analysis

All Science Journal Classification (ASJC) codes

  • Hematology
  • Cancer Research
  • Anesthesiology and Pain Medicine

Cite this

Morgan, G. J., Johnson, D. C., Weinhold, N., Goldschmidt, H., Landgren, O., Lynch, H. T., ... Houlston, R. S. (2014). Inherited genetic susceptibility to multiple myeloma. Leukemia, 28(3), 518-524. https://doi.org/10.1038/leu.2013.344

Inherited genetic susceptibility to multiple myeloma. / Morgan, G. J.; Johnson, D. C.; Weinhold, N.; Goldschmidt, H.; Landgren, O.; Lynch, Henry T.; Hemminki, K.; Houlston, R. S.

In: Leukemia, Vol. 28, No. 3, 2014, p. 518-524.

Research output: Contribution to journalReview article

Morgan, GJ, Johnson, DC, Weinhold, N, Goldschmidt, H, Landgren, O, Lynch, HT, Hemminki, K & Houlston, RS 2014, 'Inherited genetic susceptibility to multiple myeloma', Leukemia, vol. 28, no. 3, pp. 518-524. https://doi.org/10.1038/leu.2013.344
Morgan GJ, Johnson DC, Weinhold N, Goldschmidt H, Landgren O, Lynch HT et al. Inherited genetic susceptibility to multiple myeloma. Leukemia. 2014;28(3):518-524. https://doi.org/10.1038/leu.2013.344
Morgan, G. J. ; Johnson, D. C. ; Weinhold, N. ; Goldschmidt, H. ; Landgren, O. ; Lynch, Henry T. ; Hemminki, K. ; Houlston, R. S. / Inherited genetic susceptibility to multiple myeloma. In: Leukemia. 2014 ; Vol. 28, No. 3. pp. 518-524.
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