Inherited genetic susceptibility to multiple myeloma

G. J. Morgan, D. C. Johnson, N. Weinhold, H. Goldschmidt, O. Landgren, H. T. Lynch, K. Hemminki, R. S. Houlston

Research output: Contribution to journalReview article

43 Scopus citations

Abstract

Although the familial clustering of multiple myeloma (MM) supports the role of inherited susceptibility, only recently has direct evidence for genetic predisposition been demonstrated. A meta-analysis of two genome-wide association (GWA) studies has identified single-nucleotide polymorphisms (SNPs) localising to a number of genomic regions that are robustly associated with MM risk. In this review, we provide an overview of the evidence supporting a genetic contribution to the predisposition to MM and MGUS (monoclonal gammopathy of unknown significance), and the insight this gives into the biological basis of disease aetiology. We also highlight the promise of future approaches to identify further specific risk factors and their potential clinical utility.

Original languageEnglish (US)
Pages (from-to)518-524
Number of pages7
JournalLeukemia
Volume28
Issue number3
DOIs
StatePublished - Mar 2014

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Cancer Research

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    Morgan, G. J., Johnson, D. C., Weinhold, N., Goldschmidt, H., Landgren, O., Lynch, H. T., Hemminki, K., & Houlston, R. S. (2014). Inherited genetic susceptibility to multiple myeloma. Leukemia, 28(3), 518-524. https://doi.org/10.1038/leu.2013.344