TY - JOUR
T1 - Inhibin B is a better marker of spermatogenesis than other hormones in the evaluation of male factor infertility
AU - Kumanov, Philip
AU - Nandipati, Kalyana C.
AU - Tomova, Analia
AU - Agarwal, Ashok
PY - 2006/8
Y1 - 2006/8
N2 - Objective: To assess the role of inhibin B in the evaluation of male factor infertility. Design: Prospective study. Setting: Reproductive endocrinology clinic. Patient(s): Seventy-five patients with infertility problems (mean age 31.2 ± 7.5 years) and 12 controls (32.1 ± 8.8 years) with proven fertility. Intervention(s): None. Main Outcome Measure(s): Semen analysis was performed according to World Health Organization guidelines. Testicular volume was assessed with the Prader's orchidometer. Serum levels of inhibin B (pg/mL), LH (mIU/mL), FSH (mIU/mL), prolactin (micro IU/mL), and testosterone (nmol/L) were assessed. Result(s): The mean ± SEM inhibin B and testosterone levels were significantly lower in the patients than in the controls (inhibin B: 116.4 ± 11.7 vs. 181.2 ± 20.9, P=.008; testosterone: 13.6 ± 0.9 vs. 25.1 ± 2.9, P=.008). In general, sperm count and testicular volume in the patients were significantly and positively correlated with inhibin B (sperm count: r = 0.476, P
AB - Objective: To assess the role of inhibin B in the evaluation of male factor infertility. Design: Prospective study. Setting: Reproductive endocrinology clinic. Patient(s): Seventy-five patients with infertility problems (mean age 31.2 ± 7.5 years) and 12 controls (32.1 ± 8.8 years) with proven fertility. Intervention(s): None. Main Outcome Measure(s): Semen analysis was performed according to World Health Organization guidelines. Testicular volume was assessed with the Prader's orchidometer. Serum levels of inhibin B (pg/mL), LH (mIU/mL), FSH (mIU/mL), prolactin (micro IU/mL), and testosterone (nmol/L) were assessed. Result(s): The mean ± SEM inhibin B and testosterone levels were significantly lower in the patients than in the controls (inhibin B: 116.4 ± 11.7 vs. 181.2 ± 20.9, P=.008; testosterone: 13.6 ± 0.9 vs. 25.1 ± 2.9, P=.008). In general, sperm count and testicular volume in the patients were significantly and positively correlated with inhibin B (sperm count: r = 0.476, P
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U2 - 10.1016/j.fertnstert.2006.01.022
DO - 10.1016/j.fertnstert.2006.01.022
M3 - Article
C2 - 16764873
AN - SCOPUS:33746561251
VL - 86
SP - 332
EP - 338
JO - Fertility and Sterility
JF - Fertility and Sterility
SN - 0015-0282
IS - 2
ER -