Inhibition of cancer cell migration by gold nanorods

Molecular mechanisms and implications for cancer therapy

Teng Zhou, Meifang Yu, Bo Zhang, Liming Wang, Xiaochun Wu, Hejiang Zhou, Yipeng Du, Junfeng Hao, Yaping Tu, Chunying Chen, Taotao Wei

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Gold nanorods have received much attention because of their distinct physicochemical properties and promising applications in bioimaging, biosensing, drug delivery, photothermal therapy, and optoelectronic devices. However, little is known regarding their effect on tumor metastasis. In the present investigation, serum protein-coated gold nanorods (AuNRs) at low concentrations is shown to exhibit no apparent effects on the viability and proliferation of three different metastatic cancer cell lines, that is, MDA-MB-231 human breast cancer cells, PC3 human prostate cancer cells, and B16F10 mouse melanoma cells, but effectively inhibit their migration and invasion in vitro. Quantitative proteomics and real-time PCR array analyses indicate that exposure of cells to AuNRs can down-regulate the expression of diverse energy generation-related genes, which accounts for their inhibition of mitochondrial oxidative phosphorylation (OXPHOS) and glycolysis. The impairment of OXPHOS and glycolysis results in a distinctive reduction of ATP production and subsequent inhibition of F-actin cytoskeletal assembly, which is crucial for the migration and invasion of cancer cells. The inhibitory effect of AuNRs on cancer cell migration is also confirmed in vivo. Taken together, the unique mechanism in inhibiting cancer cell migration by AuNRs might provide a new approach to specific cancer therapeutic treatment.

Original languageEnglish
Pages (from-to)6922-6932
Number of pages11
JournalAdvanced Functional Materials
Volume24
Issue number44
DOIs
StatePublished - Nov 26 2014

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Nanorods
Gold
nanorods
therapy
cancer
Cells
gold
glycolysis
phosphorylation
Enzyme inhibition
multiple docking adapters
Adenosinetriphosphate
Drug delivery
adenosine triphosphate
impairment
Optoelectronic devices
metastasis
optoelectronic devices
Actins
Blood Proteins

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Electrochemistry
  • Condensed Matter Physics
  • Electronic, Optical and Magnetic Materials

Cite this

Inhibition of cancer cell migration by gold nanorods : Molecular mechanisms and implications for cancer therapy. / Zhou, Teng; Yu, Meifang; Zhang, Bo; Wang, Liming; Wu, Xiaochun; Zhou, Hejiang; Du, Yipeng; Hao, Junfeng; Tu, Yaping; Chen, Chunying; Wei, Taotao.

In: Advanced Functional Materials, Vol. 24, No. 44, 26.11.2014, p. 6922-6932.

Research output: Contribution to journalArticle

Zhou, T, Yu, M, Zhang, B, Wang, L, Wu, X, Zhou, H, Du, Y, Hao, J, Tu, Y, Chen, C & Wei, T 2014, 'Inhibition of cancer cell migration by gold nanorods: Molecular mechanisms and implications for cancer therapy', Advanced Functional Materials, vol. 24, no. 44, pp. 6922-6932. https://doi.org/10.1002/adfm.201401642
Zhou, Teng ; Yu, Meifang ; Zhang, Bo ; Wang, Liming ; Wu, Xiaochun ; Zhou, Hejiang ; Du, Yipeng ; Hao, Junfeng ; Tu, Yaping ; Chen, Chunying ; Wei, Taotao. / Inhibition of cancer cell migration by gold nanorods : Molecular mechanisms and implications for cancer therapy. In: Advanced Functional Materials. 2014 ; Vol. 24, No. 44. pp. 6922-6932.
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