Inhibitory effect of nifedipine and cromolyn sodium on skin reactions and 45ca uptake and histamine release in rat mast cells induced by various stimulating agents

Yoshiro Tanizaki, Katsumi Akagi, Kyung Nam Lee, Robert G. Townley

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

The effect of nifedipine, one of the calcium channel antagonists, was examined in allergic and nonspecific reactions using rat skin and peritoneal mast cells. Rat passive cutaneous anaphylaxis response mediated by IgE antibody was inhibited by nifedipine (100 μg/rat) and also by cromolyn sodium (5 mg/rat). Skin reactions induced by histamine or methacholine were not inhibited, and skin reaction induced by serotonin was slightly inhibited by these drugs. The 45Ca uptake and histamine release in sensitized mast cells stimulated by ovalbumin were suppressed by nifedipine. In actively sensitized cells, nifedipine seems to be more effective on the inhibition of 45Ca uptake, but less effective on histamine release than cromolyn sodium. In mast cells, nonimmunologically stimulated by concanavalin A, compound 48/80, and calcium ionophore A23187, nifedipine exerted considerable inhibitory effects on both 45Ca and histamine release.

Original languageEnglish (US)
Pages (from-to)102-109
Number of pages8
JournalInternational Archives of Allergy and Immunology
Volume72
Issue number2
DOIs
StatePublished - Jan 1 1983

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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