Inhibitory effect of terfenadine on mediator release from human blood basophils and eosinophils

M. NABE; D. K. AGRAWAL; E. U. SARMIENTO; R. G. TOWNLEY

doi:10.1111/j.1365-2222.1989.tb02426.x

Inhibitory effect of terfenadine on mediator release from human blood basophils and eosinophils

M. NABE, D. K. AGRAWAL, E. U. SARMIENTO, R. G. TOWNLEY

Department of Medicine

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

The effect of terfenadine on histamine release from human basophils and LTC₄ production and release from human eosinophils was evaluated. Eosinophils and basophils were obtained by discontinuous gradient centrifugation of the peripheral blood of atopic asthma patients who were off medication. Anti-IgE-induced histamine release from human basophils was significantly inhibited by terfenadine. Maximum inhibition was obtained at 1 x 10^-5 M terfenadine (percentage inhibition = 57.0 ± 20.1; P <0.05). However, only the highest dose of terfenadine used in this study, i.e. 2 x 10^-5 M, significantly inhibited calcium ionophore (A23187)-induced histamine release from human basophils (percentage inhibition = 40.0 ± 14.6; P <0.05), and LTC₄ production from human eosinophils (percentage inhibition 59.8 ± 9.9; P <0.05). These findings demonstrate that terfenadine, in addition to its known antihistaminic property, also has an inhibitory effect on chemical mediator release.

Original language	English (US)
Pages (from-to)	515-520
Number of pages	6
Journal	Clinical & Experimental Allergy
Volume	19
Issue number	5
DOIs	https://doi.org/10.1111/j.1365-2222.1989.tb02426.x
State	Published - Sep 1989

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology

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10.1111/j.1365-2222.1989.tb02426.x

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title = "Inhibitory effect of terfenadine on mediator release from human blood basophils and eosinophils",

abstract = "The effect of terfenadine on histamine release from human basophils and LTC4 production and release from human eosinophils was evaluated. Eosinophils and basophils were obtained by discontinuous gradient centrifugation of the peripheral blood of atopic asthma patients who were off medication. Anti-IgE-induced histamine release from human basophils was significantly inhibited by terfenadine. Maximum inhibition was obtained at 1 x 10-5 M terfenadine (percentage inhibition = 57.0 ± 20.1; P <0.05). However, only the highest dose of terfenadine used in this study, i.e. 2 x 10-5 M, significantly inhibited calcium ionophore (A23187)-induced histamine release from human basophils (percentage inhibition = 40.0 ± 14.6; P <0.05), and LTC4 production from human eosinophils (percentage inhibition 59.8 ± 9.9; P <0.05). These findings demonstrate that terfenadine, in addition to its known antihistaminic property, also has an inhibitory effect on chemical mediator release.",

author = "M. NABE and AGRAWAL, {D. K.} and SARMIENTO, {E. U.} and TOWNLEY, {R. G.}",

year = "1989",

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AU - NABE, M.

AU - AGRAWAL, D. K.

AU - SARMIENTO, E. U.

AU - TOWNLEY, R. G.

PY - 1989/9

Y1 - 1989/9

N2 - The effect of terfenadine on histamine release from human basophils and LTC4 production and release from human eosinophils was evaluated. Eosinophils and basophils were obtained by discontinuous gradient centrifugation of the peripheral blood of atopic asthma patients who were off medication. Anti-IgE-induced histamine release from human basophils was significantly inhibited by terfenadine. Maximum inhibition was obtained at 1 x 10-5 M terfenadine (percentage inhibition = 57.0 ± 20.1; P <0.05). However, only the highest dose of terfenadine used in this study, i.e. 2 x 10-5 M, significantly inhibited calcium ionophore (A23187)-induced histamine release from human basophils (percentage inhibition = 40.0 ± 14.6; P <0.05), and LTC4 production from human eosinophils (percentage inhibition 59.8 ± 9.9; P <0.05). These findings demonstrate that terfenadine, in addition to its known antihistaminic property, also has an inhibitory effect on chemical mediator release.

AB - The effect of terfenadine on histamine release from human basophils and LTC4 production and release from human eosinophils was evaluated. Eosinophils and basophils were obtained by discontinuous gradient centrifugation of the peripheral blood of atopic asthma patients who were off medication. Anti-IgE-induced histamine release from human basophils was significantly inhibited by terfenadine. Maximum inhibition was obtained at 1 x 10-5 M terfenadine (percentage inhibition = 57.0 ± 20.1; P <0.05). However, only the highest dose of terfenadine used in this study, i.e. 2 x 10-5 M, significantly inhibited calcium ionophore (A23187)-induced histamine release from human basophils (percentage inhibition = 40.0 ± 14.6; P <0.05), and LTC4 production from human eosinophils (percentage inhibition 59.8 ± 9.9; P <0.05). These findings demonstrate that terfenadine, in addition to its known antihistaminic property, also has an inhibitory effect on chemical mediator release.

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Inhibitory effect of terfenadine on mediator release from human blood basophils and eosinophils

Abstract

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