Initial experience with Barrett's strip endoscopic mucosal excision

A new Barrett's excision device

András Légner, Rudolf J. Stadlhuber, Fumiaki Yano, Kazuto Tsuboi, Sumeet K. Mittal, Richard I. Rothstein, Charles Filipi

Research output: Contribution to journalArticle

Abstract

Background Barrett's mucosa resection techniques are time consuming, often difficult to perform, and used with varying success. This report describes the authors' results with a new device and technique for strip endoscopic mucosal resection (SEMR) using a cold excision blade. Methods A retrospective review of ex vivo and in vivo animal and human esophagi experiments was conducted to develop the essential design characteristics of a transoral strip mucosal excision device. Depth, size, shape, and technique of excision were serially evaluated. Results The SEMR device allows precise capsule positioning with satisfactory excision size and depth in ex vivo and in vivo experiments. A total of 10 excisions were performed on five normal ex vivo cadaveric human esophagi. The specimens ranged in size from 3 × 2.5 to 2.5 × 2.2 cm. The average specimen thickness was 0.297 mm. For 147 (99.8%) of 150 fields of examination, muscularis mucosa was included. Six additional in vivo experiments demonstrated device safety and feasibility. Conclusion Satisfactory excision depth was reproducible. Further animal survival experiments and clinical trials will define the role of the SEMR device for patients with Barrett's esophagus.

Original languageEnglish
Pages (from-to)651-654
Number of pages4
JournalSurgical Endoscopy
Volume25
Issue number2
DOIs
StatePublished - Feb 2011

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Equipment and Supplies
Esophagus
Mucous Membrane
Equipment Safety
Barrett Esophagus
Capsules
Clinical Trials
Endoscopic Mucosal Resection

All Science Journal Classification (ASJC) codes

  • Surgery

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Initial experience with Barrett's strip endoscopic mucosal excision : A new Barrett's excision device. / Légner, András; Stadlhuber, Rudolf J.; Yano, Fumiaki; Tsuboi, Kazuto; Mittal, Sumeet K.; Rothstein, Richard I.; Filipi, Charles.

In: Surgical Endoscopy, Vol. 25, No. 2, 02.2011, p. 651-654.

Research output: Contribution to journalArticle

Légner, A, Stadlhuber, RJ, Yano, F, Tsuboi, K, Mittal, SK, Rothstein, RI & Filipi, C 2011, 'Initial experience with Barrett's strip endoscopic mucosal excision: A new Barrett's excision device', Surgical Endoscopy, vol. 25, no. 2, pp. 651-654. https://doi.org/10.1007/s00464-010-1192-x
Légner, András ; Stadlhuber, Rudolf J. ; Yano, Fumiaki ; Tsuboi, Kazuto ; Mittal, Sumeet K. ; Rothstein, Richard I. ; Filipi, Charles. / Initial experience with Barrett's strip endoscopic mucosal excision : A new Barrett's excision device. In: Surgical Endoscopy. 2011 ; Vol. 25, No. 2. pp. 651-654.
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