Insights gained from symptom evaluation of esophageal motility disorders

A review of 4,215 patients

Kazuto Tsuboi, Masato Hoshino, Ananth Srinivasan, Fumiaki Yano, Ronald A. Hinder, Tom R. Demeester, Charles Filipi, Sumeet K. Mittal

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

Background/Aims: Achalasia (Ach), diffuse esophageal spasm (DES), nutcracker esophagus (NE), and nonspecific motility disorder (NSMD) are described primary esophageal body motility disorders; however, their clinical symptom correlation is poorly understood. The aim of this study is to examine the association between a patient's presenting symptoms and their manometric diagnosis. Methods: Manometric findings and reported symptoms of all patients undergoing esophageal manometry at the Creighton University Medical Center were prospectively entered in a database. Twenty-four-year data from 1984 through 2008 were accessed and analyzed. Results: Of the 4,215 patients, 130 (3.1%) had Ach, 192 (4.6%) had DES, 290 (6.9%) had NE, 508 (12.1%) had NSMD, and 3,095 (73.4%) had normal esophageal body motility. There was significant symptom overlap between the groups. Ach and DES had a similar symptom distribution, with dysphagia being the predominant symptom. Patients with NE, normal body motility, and NSMD presented predominantly with reflux symptoms. There was an increasing prevalence of esophageal dysmotility (DES and NSMD) with age, and women were found to be more likely to have NE than men. Conclusion: In an individual, reported symptoms do not correlate with their manometric diagnosis in a predictable fashion, and a thorough physiological assessment should be obtained to understand and diagnose the disease process. Esophageal motility deteriorates with age.

Original languageEnglish
Pages (from-to)236-242
Number of pages7
JournalDigestion
Volume85
Issue number3
DOIs
StatePublished - May 2012

Fingerprint

Esophageal Motility Disorders
Symptom Assessment
Diffuse Esophageal Spasm
Esophageal Achalasia
Manometry
Deglutition Disorders
Databases

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Tsuboi, K., Hoshino, M., Srinivasan, A., Yano, F., Hinder, R. A., Demeester, T. R., ... Mittal, S. K. (2012). Insights gained from symptom evaluation of esophageal motility disorders: A review of 4,215 patients. Digestion, 85(3), 236-242. https://doi.org/10.1159/000336072

Insights gained from symptom evaluation of esophageal motility disorders : A review of 4,215 patients. / Tsuboi, Kazuto; Hoshino, Masato; Srinivasan, Ananth; Yano, Fumiaki; Hinder, Ronald A.; Demeester, Tom R.; Filipi, Charles; Mittal, Sumeet K.

In: Digestion, Vol. 85, No. 3, 05.2012, p. 236-242.

Research output: Contribution to journalReview article

Tsuboi, K, Hoshino, M, Srinivasan, A, Yano, F, Hinder, RA, Demeester, TR, Filipi, C & Mittal, SK 2012, 'Insights gained from symptom evaluation of esophageal motility disorders: A review of 4,215 patients', Digestion, vol. 85, no. 3, pp. 236-242. https://doi.org/10.1159/000336072
Tsuboi K, Hoshino M, Srinivasan A, Yano F, Hinder RA, Demeester TR et al. Insights gained from symptom evaluation of esophageal motility disorders: A review of 4,215 patients. Digestion. 2012 May;85(3):236-242. https://doi.org/10.1159/000336072
Tsuboi, Kazuto ; Hoshino, Masato ; Srinivasan, Ananth ; Yano, Fumiaki ; Hinder, Ronald A. ; Demeester, Tom R. ; Filipi, Charles ; Mittal, Sumeet K. / Insights gained from symptom evaluation of esophageal motility disorders : A review of 4,215 patients. In: Digestion. 2012 ; Vol. 85, No. 3. pp. 236-242.
@article{beec5d373b6d435c93399f4b4e82e191,
title = "Insights gained from symptom evaluation of esophageal motility disorders: A review of 4,215 patients",
abstract = "Background/Aims: Achalasia (Ach), diffuse esophageal spasm (DES), nutcracker esophagus (NE), and nonspecific motility disorder (NSMD) are described primary esophageal body motility disorders; however, their clinical symptom correlation is poorly understood. The aim of this study is to examine the association between a patient's presenting symptoms and their manometric diagnosis. Methods: Manometric findings and reported symptoms of all patients undergoing esophageal manometry at the Creighton University Medical Center were prospectively entered in a database. Twenty-four-year data from 1984 through 2008 were accessed and analyzed. Results: Of the 4,215 patients, 130 (3.1{\%}) had Ach, 192 (4.6{\%}) had DES, 290 (6.9{\%}) had NE, 508 (12.1{\%}) had NSMD, and 3,095 (73.4{\%}) had normal esophageal body motility. There was significant symptom overlap between the groups. Ach and DES had a similar symptom distribution, with dysphagia being the predominant symptom. Patients with NE, normal body motility, and NSMD presented predominantly with reflux symptoms. There was an increasing prevalence of esophageal dysmotility (DES and NSMD) with age, and women were found to be more likely to have NE than men. Conclusion: In an individual, reported symptoms do not correlate with their manometric diagnosis in a predictable fashion, and a thorough physiological assessment should be obtained to understand and diagnose the disease process. Esophageal motility deteriorates with age.",
author = "Kazuto Tsuboi and Masato Hoshino and Ananth Srinivasan and Fumiaki Yano and Hinder, {Ronald A.} and Demeester, {Tom R.} and Charles Filipi and Mittal, {Sumeet K.}",
year = "2012",
month = "5",
doi = "10.1159/000336072",
language = "English",
volume = "85",
pages = "236--242",
journal = "Digestion",
issn = "0012-2823",
publisher = "S. Karger AG",
number = "3",

}

TY - JOUR

T1 - Insights gained from symptom evaluation of esophageal motility disorders

T2 - A review of 4,215 patients

AU - Tsuboi, Kazuto

AU - Hoshino, Masato

AU - Srinivasan, Ananth

AU - Yano, Fumiaki

AU - Hinder, Ronald A.

AU - Demeester, Tom R.

AU - Filipi, Charles

AU - Mittal, Sumeet K.

PY - 2012/5

Y1 - 2012/5

N2 - Background/Aims: Achalasia (Ach), diffuse esophageal spasm (DES), nutcracker esophagus (NE), and nonspecific motility disorder (NSMD) are described primary esophageal body motility disorders; however, their clinical symptom correlation is poorly understood. The aim of this study is to examine the association between a patient's presenting symptoms and their manometric diagnosis. Methods: Manometric findings and reported symptoms of all patients undergoing esophageal manometry at the Creighton University Medical Center were prospectively entered in a database. Twenty-four-year data from 1984 through 2008 were accessed and analyzed. Results: Of the 4,215 patients, 130 (3.1%) had Ach, 192 (4.6%) had DES, 290 (6.9%) had NE, 508 (12.1%) had NSMD, and 3,095 (73.4%) had normal esophageal body motility. There was significant symptom overlap between the groups. Ach and DES had a similar symptom distribution, with dysphagia being the predominant symptom. Patients with NE, normal body motility, and NSMD presented predominantly with reflux symptoms. There was an increasing prevalence of esophageal dysmotility (DES and NSMD) with age, and women were found to be more likely to have NE than men. Conclusion: In an individual, reported symptoms do not correlate with their manometric diagnosis in a predictable fashion, and a thorough physiological assessment should be obtained to understand and diagnose the disease process. Esophageal motility deteriorates with age.

AB - Background/Aims: Achalasia (Ach), diffuse esophageal spasm (DES), nutcracker esophagus (NE), and nonspecific motility disorder (NSMD) are described primary esophageal body motility disorders; however, their clinical symptom correlation is poorly understood. The aim of this study is to examine the association between a patient's presenting symptoms and their manometric diagnosis. Methods: Manometric findings and reported symptoms of all patients undergoing esophageal manometry at the Creighton University Medical Center were prospectively entered in a database. Twenty-four-year data from 1984 through 2008 were accessed and analyzed. Results: Of the 4,215 patients, 130 (3.1%) had Ach, 192 (4.6%) had DES, 290 (6.9%) had NE, 508 (12.1%) had NSMD, and 3,095 (73.4%) had normal esophageal body motility. There was significant symptom overlap between the groups. Ach and DES had a similar symptom distribution, with dysphagia being the predominant symptom. Patients with NE, normal body motility, and NSMD presented predominantly with reflux symptoms. There was an increasing prevalence of esophageal dysmotility (DES and NSMD) with age, and women were found to be more likely to have NE than men. Conclusion: In an individual, reported symptoms do not correlate with their manometric diagnosis in a predictable fashion, and a thorough physiological assessment should be obtained to understand and diagnose the disease process. Esophageal motility deteriorates with age.

UR - http://www.scopus.com/inward/record.url?scp=84859152204&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84859152204&partnerID=8YFLogxK

U2 - 10.1159/000336072

DO - 10.1159/000336072

M3 - Review article

VL - 85

SP - 236

EP - 242

JO - Digestion

JF - Digestion

SN - 0012-2823

IS - 3

ER -