Interaction of Phytopharmaceuticals with Neurotransmitters in the Brain

Leah Mitchell-Bush, Jenaye Robinson, Odochi I. Ohia-Nwoko, Emily Kawesa-Bass, Benjamin A. Stancombe, Catherine A. Opere, Ya Fatou Njie-Mbye, Sunny E. Ohia

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Chemicals derived from plant sources have been used since prehistoric times for the treatment of diseases. Based on the prevalence of brain diseases such as Parkinson’s, dementia, amyotrophic lateral sclerosis (ALS), and epilepsy, both preclinical and clinical studies using natural phytochemicals have been vigorously pursued in the search for more effective therapies for these diseases. Parkinson’s disease (PD) is a progressive neurodegenerative brain disorder that affects motor function. Symptoms of PD typically include uncontrolled tremor while at rest, bradykinesia, and rigidity. Dementias are brain diseases most notably characterized by a gradual decline in memory. Extracts from sage plants have been used to treat a variety of diseases and ailments in traditional medicine. Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease characterized by loss of motor neurons in the brain and spinal cord. Epilepsy is a group of neurological disorders defined by epileptic seizures.

Original languageEnglish (US)
Title of host publicationPhytopharmaceuticals for Brain Health
PublisherCRC Press
Pages309-322
Number of pages14
ISBN (Electronic)9781498757683
ISBN (Print)9781498757676
DOIs
StatePublished - Jan 1 2017

All Science Journal Classification (ASJC) codes

  • Engineering(all)
  • Agricultural and Biological Sciences(all)
  • Neuroscience(all)

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