International rates of breast reconstruction after prophylactic mastectomy in BRCA1 and BRCA2 mutation carriers

John Semple, Kelly A. Metcalfe, Henry T. Lynch, Charmaine Kim-Sing, Leigha Senter, Tuya Pal, Peter Ainsworth, Jan Lubinski, Nadine Tung, Charis Eng, Donna Gilchrist, Joanne Blum, Susan L. Neuhausen, Christian F. Singer, Parviz Ghadirian, Ping Sun, Steven A. Narod

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Abstract

Background: Breast reconstruction is an option for women with BRCA1 or BRCA2 mutations who elect to undergo prophylactic mastectomy to prevent breast cancer. We report on the uptake of breast reconstruction after prophylactic mastectomy in women with BRCA mutations from eight countries. Methods: Women with a BRCA1 or BRCA2 mutation were questioned regarding their cancer preventive practices. Information was recorded on prophylactic mastectomy and breast reconstruction. Results: A total of 1,635 women with a BRCA1 or BRCA2 mutation who elected to undergo prophylactic mastectomy from eight countries were included. A total of 1,137 women (69.5 %) had breast reconstruction after prophylactic mastectomy. A total of 58.7 % of women over the age of 45 years at the time of prophylactic mastectomy had breast reconstruction compared to 77.6 % of women 35 years of age or younger [odds ratio (OR) 0.36, 95 % confidence interval (CI) 0.26-0.50, p <0.001]. In addition, 62.9 % of women with a breast cancer diagnosis (contralateral prophylactic mastectomy) had breast reconstruction after prophylactic mastectomy compared to 79.7 % of women without a previous breast cancer diagnosis (OR 0.48, 95 % CI 0.38-0.61, p <0.001). A total of 66.9 % of women from Canada had breast reconstruction after mastectomy compared to 71.9 % of American women (OR 0.75, 95 % CI 0.59-0.96, p = 0.02). Conclusions: The majority of women elect for breast reconstruction after prophylactic mastectomy. However, younger women and those without a previous diagnosis of breast cancer are more likely to have breast reconstruction than older women or those with a previous diagnosis of cancer.

Original languageEnglish
Pages (from-to)3817-3822
Number of pages6
JournalAnnals of Surgical Oncology
Volume20
Issue number12
DOIs
StatePublished - Nov 2013

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Mammaplasty
Mutation
Breast Neoplasms
Odds Ratio
Confidence Intervals
Prophylactic Mastectomy
Mastectomy
Canada
Neoplasms

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

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International rates of breast reconstruction after prophylactic mastectomy in BRCA1 and BRCA2 mutation carriers. / Semple, John; Metcalfe, Kelly A.; Lynch, Henry T.; Kim-Sing, Charmaine; Senter, Leigha; Pal, Tuya; Ainsworth, Peter; Lubinski, Jan; Tung, Nadine; Eng, Charis; Gilchrist, Donna; Blum, Joanne; Neuhausen, Susan L.; Singer, Christian F.; Ghadirian, Parviz; Sun, Ping; Narod, Steven A.

In: Annals of Surgical Oncology, Vol. 20, No. 12, 11.2013, p. 3817-3822.

Research output: Contribution to journalArticle

Semple, J, Metcalfe, KA, Lynch, HT, Kim-Sing, C, Senter, L, Pal, T, Ainsworth, P, Lubinski, J, Tung, N, Eng, C, Gilchrist, D, Blum, J, Neuhausen, SL, Singer, CF, Ghadirian, P, Sun, P & Narod, SA 2013, 'International rates of breast reconstruction after prophylactic mastectomy in BRCA1 and BRCA2 mutation carriers', Annals of Surgical Oncology, vol. 20, no. 12, pp. 3817-3822. https://doi.org/10.1245/s10434-013-3040-4
Semple, John ; Metcalfe, Kelly A. ; Lynch, Henry T. ; Kim-Sing, Charmaine ; Senter, Leigha ; Pal, Tuya ; Ainsworth, Peter ; Lubinski, Jan ; Tung, Nadine ; Eng, Charis ; Gilchrist, Donna ; Blum, Joanne ; Neuhausen, Susan L. ; Singer, Christian F. ; Ghadirian, Parviz ; Sun, Ping ; Narod, Steven A. / International rates of breast reconstruction after prophylactic mastectomy in BRCA1 and BRCA2 mutation carriers. In: Annals of Surgical Oncology. 2013 ; Vol. 20, No. 12. pp. 3817-3822.
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title = "International rates of breast reconstruction after prophylactic mastectomy in BRCA1 and BRCA2 mutation carriers",
abstract = "Background: Breast reconstruction is an option for women with BRCA1 or BRCA2 mutations who elect to undergo prophylactic mastectomy to prevent breast cancer. We report on the uptake of breast reconstruction after prophylactic mastectomy in women with BRCA mutations from eight countries. Methods: Women with a BRCA1 or BRCA2 mutation were questioned regarding their cancer preventive practices. Information was recorded on prophylactic mastectomy and breast reconstruction. Results: A total of 1,635 women with a BRCA1 or BRCA2 mutation who elected to undergo prophylactic mastectomy from eight countries were included. A total of 1,137 women (69.5 {\%}) had breast reconstruction after prophylactic mastectomy. A total of 58.7 {\%} of women over the age of 45 years at the time of prophylactic mastectomy had breast reconstruction compared to 77.6 {\%} of women 35 years of age or younger [odds ratio (OR) 0.36, 95 {\%} confidence interval (CI) 0.26-0.50, p <0.001]. In addition, 62.9 {\%} of women with a breast cancer diagnosis (contralateral prophylactic mastectomy) had breast reconstruction after prophylactic mastectomy compared to 79.7 {\%} of women without a previous breast cancer diagnosis (OR 0.48, 95 {\%} CI 0.38-0.61, p <0.001). A total of 66.9 {\%} of women from Canada had breast reconstruction after mastectomy compared to 71.9 {\%} of American women (OR 0.75, 95 {\%} CI 0.59-0.96, p = 0.02). Conclusions: The majority of women elect for breast reconstruction after prophylactic mastectomy. However, younger women and those without a previous diagnosis of breast cancer are more likely to have breast reconstruction than older women or those with a previous diagnosis of cancer.",
author = "John Semple and Metcalfe, {Kelly A.} and Lynch, {Henry T.} and Charmaine Kim-Sing and Leigha Senter and Tuya Pal and Peter Ainsworth and Jan Lubinski and Nadine Tung and Charis Eng and Donna Gilchrist and Joanne Blum and Neuhausen, {Susan L.} and Singer, {Christian F.} and Parviz Ghadirian and Ping Sun and Narod, {Steven A.}",
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T1 - International rates of breast reconstruction after prophylactic mastectomy in BRCA1 and BRCA2 mutation carriers

AU - Semple, John

AU - Metcalfe, Kelly A.

AU - Lynch, Henry T.

AU - Kim-Sing, Charmaine

AU - Senter, Leigha

AU - Pal, Tuya

AU - Ainsworth, Peter

AU - Lubinski, Jan

AU - Tung, Nadine

AU - Eng, Charis

AU - Gilchrist, Donna

AU - Blum, Joanne

AU - Neuhausen, Susan L.

AU - Singer, Christian F.

AU - Ghadirian, Parviz

AU - Sun, Ping

AU - Narod, Steven A.

PY - 2013/11

Y1 - 2013/11

N2 - Background: Breast reconstruction is an option for women with BRCA1 or BRCA2 mutations who elect to undergo prophylactic mastectomy to prevent breast cancer. We report on the uptake of breast reconstruction after prophylactic mastectomy in women with BRCA mutations from eight countries. Methods: Women with a BRCA1 or BRCA2 mutation were questioned regarding their cancer preventive practices. Information was recorded on prophylactic mastectomy and breast reconstruction. Results: A total of 1,635 women with a BRCA1 or BRCA2 mutation who elected to undergo prophylactic mastectomy from eight countries were included. A total of 1,137 women (69.5 %) had breast reconstruction after prophylactic mastectomy. A total of 58.7 % of women over the age of 45 years at the time of prophylactic mastectomy had breast reconstruction compared to 77.6 % of women 35 years of age or younger [odds ratio (OR) 0.36, 95 % confidence interval (CI) 0.26-0.50, p <0.001]. In addition, 62.9 % of women with a breast cancer diagnosis (contralateral prophylactic mastectomy) had breast reconstruction after prophylactic mastectomy compared to 79.7 % of women without a previous breast cancer diagnosis (OR 0.48, 95 % CI 0.38-0.61, p <0.001). A total of 66.9 % of women from Canada had breast reconstruction after mastectomy compared to 71.9 % of American women (OR 0.75, 95 % CI 0.59-0.96, p = 0.02). Conclusions: The majority of women elect for breast reconstruction after prophylactic mastectomy. However, younger women and those without a previous diagnosis of breast cancer are more likely to have breast reconstruction than older women or those with a previous diagnosis of cancer.

AB - Background: Breast reconstruction is an option for women with BRCA1 or BRCA2 mutations who elect to undergo prophylactic mastectomy to prevent breast cancer. We report on the uptake of breast reconstruction after prophylactic mastectomy in women with BRCA mutations from eight countries. Methods: Women with a BRCA1 or BRCA2 mutation were questioned regarding their cancer preventive practices. Information was recorded on prophylactic mastectomy and breast reconstruction. Results: A total of 1,635 women with a BRCA1 or BRCA2 mutation who elected to undergo prophylactic mastectomy from eight countries were included. A total of 1,137 women (69.5 %) had breast reconstruction after prophylactic mastectomy. A total of 58.7 % of women over the age of 45 years at the time of prophylactic mastectomy had breast reconstruction compared to 77.6 % of women 35 years of age or younger [odds ratio (OR) 0.36, 95 % confidence interval (CI) 0.26-0.50, p <0.001]. In addition, 62.9 % of women with a breast cancer diagnosis (contralateral prophylactic mastectomy) had breast reconstruction after prophylactic mastectomy compared to 79.7 % of women without a previous breast cancer diagnosis (OR 0.48, 95 % CI 0.38-0.61, p <0.001). A total of 66.9 % of women from Canada had breast reconstruction after mastectomy compared to 71.9 % of American women (OR 0.75, 95 % CI 0.59-0.96, p = 0.02). Conclusions: The majority of women elect for breast reconstruction after prophylactic mastectomy. However, younger women and those without a previous diagnosis of breast cancer are more likely to have breast reconstruction than older women or those with a previous diagnosis of cancer.

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