Interspecies transmission of chronic wasting disease prions to squirrel monkeys (Saimiri sciureus)

Richard F. Marsh, Anthony E. Kincaid, Richard A. Bessen, Jason C. Bartz

Research output: Contribution to journalArticle

103 Scopus citations

Abstract

Chronic wasting disease (CWD) is an emerging prion disease of deer and elk. The risk of CWD transmission to humans following exposure to CWD-infected tissues is unknown. To assess the susceptibility of nonhuman primates to CWD, two squirrel monkeys were inoculated with brain tissue from a CWD-infected mule deer. The CWD-inoculated squirrel monkeys developed a progressive neurodegenerative disease and were euthanized at 31 and 34 months postinfection. Brain tissue from the CWD-infected squirrel monkeys contained the abnormal isoform of the prion protein, PrP-res, and displayed spongiform degeneration. This is the first reported transmission of CWD to primates.

Original languageEnglish (US)
Pages (from-to)13794-13796
Number of pages3
JournalJournal of Virology
Volume79
Issue number21
DOIs
StatePublished - Nov 1 2005

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this