Interspecies transmission of chronic wasting disease prions to squirrel monkeys (Saimiri sciureus)

Richard F. Marsh, Anthony E. Kincaid, Richard A. Bessen, Jason C. Bartz

Research output: Contribution to journalArticlepeer-review

104 Scopus citations

Abstract

Chronic wasting disease (CWD) is an emerging prion disease of deer and elk. The risk of CWD transmission to humans following exposure to CWD-infected tissues is unknown. To assess the susceptibility of nonhuman primates to CWD, two squirrel monkeys were inoculated with brain tissue from a CWD-infected mule deer. The CWD-inoculated squirrel monkeys developed a progressive neurodegenerative disease and were euthanized at 31 and 34 months postinfection. Brain tissue from the CWD-infected squirrel monkeys contained the abnormal isoform of the prion protein, PrP-res, and displayed spongiform degeneration. This is the first reported transmission of CWD to primates.

Original languageEnglish (US)
Pages (from-to)13794-13796
Number of pages3
JournalJournal of Virology
Volume79
Issue number21
DOIs
StatePublished - Nov 2005

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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