Abstract
Chronic wasting disease (CWD) is an emerging prion disease of deer and elk. The risk of CWD transmission to humans following exposure to CWD-infected tissues is unknown. To assess the susceptibility of nonhuman primates to CWD, two squirrel monkeys were inoculated with brain tissue from a CWD-infected mule deer. The CWD-inoculated squirrel monkeys developed a progressive neurodegenerative disease and were euthanized at 31 and 34 months postinfection. Brain tissue from the CWD-infected squirrel monkeys contained the abnormal isoform of the prion protein, PrP-res, and displayed spongiform degeneration. This is the first reported transmission of CWD to primates.
| Original language | English |
|---|---|
| Pages (from-to) | 13794-13796 |
| Number of pages | 3 |
| Journal | Journal of Virology |
| Volume | 79 |
| Issue number | 21 |
| DOIs | |
| State | Published - Nov 2005 |
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All Science Journal Classification (ASJC) codes
- Immunology
Cite this
Interspecies transmission of chronic wasting disease prions to squirrel monkeys (Saimiri sciureus). / Marsh, Richard F.; Kincaid, Anthony; Bessen, Richard A.; Bartz, Jason C.
In: Journal of Virology, Vol. 79, No. 21, 11.2005, p. 13794-13796.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Interspecies transmission of chronic wasting disease prions to squirrel monkeys (Saimiri sciureus)
AU - Marsh, Richard F.
AU - Kincaid, Anthony
AU - Bessen, Richard A.
AU - Bartz, Jason C.
PY - 2005/11
Y1 - 2005/11
N2 - Chronic wasting disease (CWD) is an emerging prion disease of deer and elk. The risk of CWD transmission to humans following exposure to CWD-infected tissues is unknown. To assess the susceptibility of nonhuman primates to CWD, two squirrel monkeys were inoculated with brain tissue from a CWD-infected mule deer. The CWD-inoculated squirrel monkeys developed a progressive neurodegenerative disease and were euthanized at 31 and 34 months postinfection. Brain tissue from the CWD-infected squirrel monkeys contained the abnormal isoform of the prion protein, PrP-res, and displayed spongiform degeneration. This is the first reported transmission of CWD to primates.
AB - Chronic wasting disease (CWD) is an emerging prion disease of deer and elk. The risk of CWD transmission to humans following exposure to CWD-infected tissues is unknown. To assess the susceptibility of nonhuman primates to CWD, two squirrel monkeys were inoculated with brain tissue from a CWD-infected mule deer. The CWD-inoculated squirrel monkeys developed a progressive neurodegenerative disease and were euthanized at 31 and 34 months postinfection. Brain tissue from the CWD-infected squirrel monkeys contained the abnormal isoform of the prion protein, PrP-res, and displayed spongiform degeneration. This is the first reported transmission of CWD to primates.
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U2 - 10.1128/JVI.79.21.13794-13796.2005
DO - 10.1128/JVI.79.21.13794-13796.2005
M3 - Article
VL - 79
SP - 13794
EP - 13796
JO - Journal of Virology
JF - Journal of Virology
SN - 0022-538X
IS - 21
ER -