Interspecies transmission of chronic wasting disease prions to squirrel monkeys (Saimiri sciureus)

Richard F. Marsh, Anthony Kincaid, Richard A. Bessen, Jason C. Bartz

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

Chronic wasting disease (CWD) is an emerging prion disease of deer and elk. The risk of CWD transmission to humans following exposure to CWD-infected tissues is unknown. To assess the susceptibility of nonhuman primates to CWD, two squirrel monkeys were inoculated with brain tissue from a CWD-infected mule deer. The CWD-inoculated squirrel monkeys developed a progressive neurodegenerative disease and were euthanized at 31 and 34 months postinfection. Brain tissue from the CWD-infected squirrel monkeys contained the abnormal isoform of the prion protein, PrP-res, and displayed spongiform degeneration. This is the first reported transmission of CWD to primates.

Original languageEnglish
Pages (from-to)13794-13796
Number of pages3
JournalJournal of Virology
Volume79
Issue number21
DOIs
StatePublished - Nov 2005

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Chronic Wasting Disease
chronic wasting disease
Saimiri sciureus
Saimiri
Prions
prions
Deer
Primates
PrPSc Proteins
brain
Prion Diseases
Odocoileus hemionus
prion diseases
Equidae
elks
Brain
neurodegenerative diseases
disease transmission
Neurodegenerative Diseases
deer

All Science Journal Classification (ASJC) codes

  • Immunology

Cite this

Interspecies transmission of chronic wasting disease prions to squirrel monkeys (Saimiri sciureus). / Marsh, Richard F.; Kincaid, Anthony; Bessen, Richard A.; Bartz, Jason C.

In: Journal of Virology, Vol. 79, No. 21, 11.2005, p. 13794-13796.

Research output: Contribution to journalArticle

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