Abstract
Chronic wasting disease (CWD) is an emerging prion disease of deer and elk. The risk of CWD transmission to humans following exposure to CWD-infected tissues is unknown. To assess the susceptibility of nonhuman primates to CWD, two squirrel monkeys were inoculated with brain tissue from a CWD-infected mule deer. The CWD-inoculated squirrel monkeys developed a progressive neurodegenerative disease and were euthanized at 31 and 34 months postinfection. Brain tissue from the CWD-infected squirrel monkeys contained the abnormal isoform of the prion protein, PrP-res, and displayed spongiform degeneration. This is the first reported transmission of CWD to primates.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 13794-13796 |
| Number of pages | 3 |
| Journal | Journal of Virology |
| Volume | 79 |
| Issue number | 21 |
| DOIs | |
| State | Published - Nov 1 2005 |
All Science Journal Classification (ASJC) codes
- Microbiology
- Immunology
- Insect Science
- Virology
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Marsh, R. F., Kincaid, A. E., Bessen, R. A., & Bartz, J. C. (2005). Interspecies transmission of chronic wasting disease prions to squirrel monkeys (Saimiri sciureus). Journal of Virology, 79(21), 13794-13796. https://doi.org/10.1128/JVI.79.21.13794-13796.2005