Abstract
Reduced intestinal blood flow and high intestinal temperatures during exercise-heat stress can lead to intestinal barrier dysfunction. Such dysfunction may increase intestinal permeability to endotoxin. During exercise-heat stress, intestinal barrier dysfunction and endotoxemia can produce gastrointestinal symptoms and increased production of pro-inflammatory cytokines. Such problems may be a warning sign ('canary in the coal mine') for the onset of exertional heat stroke. Failure to heed such a warning may culminate in problems indicative of exertional heat stroke such as circulatory collapse and multiple organ failure. Prior exposure to exercise-heat stress may, however, be a protective mechanism.
| Original language | English (US) |
|---|---|
| Title of host publication | Thermoregulation and Human Performance |
| Subtitle of host publication | Physiological and Biological Aspects |
| Pages | 61-73 |
| Number of pages | 13 |
| Volume | 53 |
| DOIs | |
| State | Published - Aug 29 2008 |
Publication series
| Name | Medicine and Sport Science |
|---|---|
| Volume | 53 |
| ISSN (Print) | 0254-5020 |
| ISSN (Electronic) | 1662-2812 |
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All Science Journal Classification (ASJC) codes
- Orthopedics and Sports Medicine
- Physical Therapy, Sports Therapy and Rehabilitation
Cite this
Intestinal barrier dysfunction, endotoxemia, and gastrointestinal symptoms : The 'canary in the coal mine' during exercise-heat stress? / Lambert, G. Patrick.
Thermoregulation and Human Performance: Physiological and Biological Aspects. Vol. 53 2008. p. 61-73 (Medicine and Sport Science; Vol. 53).Research output: Chapter in Book/Report/Conference proceeding › Chapter
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TY - CHAP
T1 - Intestinal barrier dysfunction, endotoxemia, and gastrointestinal symptoms
T2 - The 'canary in the coal mine' during exercise-heat stress?
AU - Lambert, G. Patrick
PY - 2008/8/29
Y1 - 2008/8/29
N2 - Reduced intestinal blood flow and high intestinal temperatures during exercise-heat stress can lead to intestinal barrier dysfunction. Such dysfunction may increase intestinal permeability to endotoxin. During exercise-heat stress, intestinal barrier dysfunction and endotoxemia can produce gastrointestinal symptoms and increased production of pro-inflammatory cytokines. Such problems may be a warning sign ('canary in the coal mine') for the onset of exertional heat stroke. Failure to heed such a warning may culminate in problems indicative of exertional heat stroke such as circulatory collapse and multiple organ failure. Prior exposure to exercise-heat stress may, however, be a protective mechanism.
AB - Reduced intestinal blood flow and high intestinal temperatures during exercise-heat stress can lead to intestinal barrier dysfunction. Such dysfunction may increase intestinal permeability to endotoxin. During exercise-heat stress, intestinal barrier dysfunction and endotoxemia can produce gastrointestinal symptoms and increased production of pro-inflammatory cytokines. Such problems may be a warning sign ('canary in the coal mine') for the onset of exertional heat stroke. Failure to heed such a warning may culminate in problems indicative of exertional heat stroke such as circulatory collapse and multiple organ failure. Prior exposure to exercise-heat stress may, however, be a protective mechanism.
UR - http://www.scopus.com/inward/record.url?scp=50149098362&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=50149098362&partnerID=8YFLogxK
U2 - 10.1159/000151550
DO - 10.1159/000151550
M3 - Chapter
C2 - 19208999
AN - SCOPUS:50149098362
SN - 9783805586481
VL - 53
T3 - Medicine and Sport Science
SP - 61
EP - 73
BT - Thermoregulation and Human Performance
ER -