Intestinal barrier dysfunction, endotoxemia, and gastrointestinal symptoms: The 'canary in the coal mine' during exercise-heat stress?

Research output: Chapter in Book/Report/Conference proceedingChapter

65 Scopus citations

Abstract

Reduced intestinal blood flow and high intestinal temperatures during exercise-heat stress can lead to intestinal barrier dysfunction. Such dysfunction may increase intestinal permeability to endotoxin. During exercise-heat stress, intestinal barrier dysfunction and endotoxemia can produce gastrointestinal symptoms and increased production of pro-inflammatory cytokines. Such problems may be a warning sign ('canary in the coal mine') for the onset of exertional heat stroke. Failure to heed such a warning may culminate in problems indicative of exertional heat stroke such as circulatory collapse and multiple organ failure. Prior exposure to exercise-heat stress may, however, be a protective mechanism.

Original languageEnglish (US)
Title of host publicationThermoregulation and Human Performance
Subtitle of host publicationPhysiological and Biological Aspects
Pages61-73
Number of pages13
DOIs
StatePublished - Aug 29 2008

Publication series

NameMedicine and Sport Science
Volume53
ISSN (Print)0254-5020
ISSN (Electronic)1662-2812

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Fingerprint Dive into the research topics of 'Intestinal barrier dysfunction, endotoxemia, and gastrointestinal symptoms: The 'canary in the coal mine' during exercise-heat stress?'. Together they form a unique fingerprint.

  • Cite this

    Lambert, G. P. (2008). Intestinal barrier dysfunction, endotoxemia, and gastrointestinal symptoms: The 'canary in the coal mine' during exercise-heat stress? In Thermoregulation and Human Performance: Physiological and Biological Aspects (pp. 61-73). (Medicine and Sport Science; Vol. 53). https://doi.org/10.1159/000151550