Intestinal barrier dysfunction, endotoxemia, and gastrointestinal symptoms

The 'canary in the coal mine' during exercise-heat stress?

Research output: Chapter in Book/Report/Conference proceedingChapter

58 Citations (Scopus)

Abstract

Reduced intestinal blood flow and high intestinal temperatures during exercise-heat stress can lead to intestinal barrier dysfunction. Such dysfunction may increase intestinal permeability to endotoxin. During exercise-heat stress, intestinal barrier dysfunction and endotoxemia can produce gastrointestinal symptoms and increased production of pro-inflammatory cytokines. Such problems may be a warning sign ('canary in the coal mine') for the onset of exertional heat stroke. Failure to heed such a warning may culminate in problems indicative of exertional heat stroke such as circulatory collapse and multiple organ failure. Prior exposure to exercise-heat stress may, however, be a protective mechanism.

Original languageEnglish (US)
Title of host publicationThermoregulation and Human Performance
Subtitle of host publicationPhysiological and Biological Aspects
Pages61-73
Number of pages13
Volume53
DOIs
StatePublished - Aug 29 2008

Publication series

NameMedicine and Sport Science
Volume53
ISSN (Print)0254-5020
ISSN (Electronic)1662-2812

Fingerprint

Canaries
Endotoxemia
Coal
Heat Stroke
Hot Temperature
Multiple Organ Failure
Endotoxins
Shock
Permeability
Cytokines
Temperature

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Lambert, G. P. (2008). Intestinal barrier dysfunction, endotoxemia, and gastrointestinal symptoms: The 'canary in the coal mine' during exercise-heat stress? In Thermoregulation and Human Performance: Physiological and Biological Aspects (Vol. 53, pp. 61-73). (Medicine and Sport Science; Vol. 53). https://doi.org/10.1159/000151550

Intestinal barrier dysfunction, endotoxemia, and gastrointestinal symptoms : The 'canary in the coal mine' during exercise-heat stress? / Lambert, G. Patrick.

Thermoregulation and Human Performance: Physiological and Biological Aspects. Vol. 53 2008. p. 61-73 (Medicine and Sport Science; Vol. 53).

Research output: Chapter in Book/Report/Conference proceedingChapter

Lambert, GP 2008, Intestinal barrier dysfunction, endotoxemia, and gastrointestinal symptoms: The 'canary in the coal mine' during exercise-heat stress? in Thermoregulation and Human Performance: Physiological and Biological Aspects. vol. 53, Medicine and Sport Science, vol. 53, pp. 61-73. https://doi.org/10.1159/000151550
Lambert GP. Intestinal barrier dysfunction, endotoxemia, and gastrointestinal symptoms: The 'canary in the coal mine' during exercise-heat stress? In Thermoregulation and Human Performance: Physiological and Biological Aspects. Vol. 53. 2008. p. 61-73. (Medicine and Sport Science). https://doi.org/10.1159/000151550
Lambert, G. Patrick. / Intestinal barrier dysfunction, endotoxemia, and gastrointestinal symptoms : The 'canary in the coal mine' during exercise-heat stress?. Thermoregulation and Human Performance: Physiological and Biological Aspects. Vol. 53 2008. pp. 61-73 (Medicine and Sport Science).
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