Intestinal calcium absorption and serum vitamin D metabolites in normal subjects and osteoporotic patients. Effect of age and dietary calcium

John Christopher G. Gallagher, B. L. Riggs, J. Eisman, A. Hamstra, S. B. Arnaud, H. F. DeLuca

Research output: Contribution to journalArticle

589 Citations (Scopus)

Abstract

Intestinal calium absorption assessed by a double-isotope method, decreased significantly with aging in 94 normal subjects (r = -0.22, P <0.025). In 52 untreated patients with postmenopausal osteoporosis, calcium absorption was significantly lower than normal when either age or habitual calcium intake was used as a covariable (P <0.001). Serum 25-hydroxyvitamin D (25-OH-D) and 1,25-dihydroxyvitamin D (1,25(OH) 2D) were measured in 44 normal subjects and 27 osteoporotic patients. For all normals, calcium absorption and serum 1,25(OH) 2D were positively correlated (r = 0.50, P <0.001). In nonelderly normal subjects (ages 30-65 yr), dietary calcium intake correlated inversely with both calcium absorption (r = -0.39, P <0.01) and with serum 1,25(OH) 2D (r= -0.5, P <0.01). Both osteoporotic patients and elderly normal subjects (ages 65-90 yr) differed from nonelderly normals in that these correlations were not present. In addition although serum 25-OH-D was normal, serum 1,25(OH) 2D was significantly decreased in both osteoporotic patients and elderly normals (P <0.001). In osteoporotic patients, calcium absorption increased significantly (P <0.001) after 7 d administration of a small dose (0.4 μg/d) of synthetic 1,25(OH) 2D 3. In osteoporotics mean serum immunoreactive parathyroid hormone was either normal (COOH-terminal assay) or low (NH 2-terminal assay) relative to age-matched controls, and mean serum phosphate was increased. The data suggest that inadequate metabolism of 25-OH-D to 1,25(OH) 2D contributes significantly to decreased calcium absorption and adaptation in both osteoporotics and elderly normal subjects. In patients with osteoporosis this abnormality could result from a decrease in factors that normally stimulate 1,25(OH) 2D production, such as the decreased parathyroid hormone secretion and increased serum phosphate demonstrated in this group. In elderly subjects a primary abnormality in metabolism of 25-OH-D to 1,25(OH) 2D, analagous to that seen in aging rats, cannot be excluded.

Original languageEnglish
Pages (from-to)729-736
Number of pages8
JournalJournal of Clinical Investigation
Volume64
Issue number3
StatePublished - 1979
Externally publishedYes

Fingerprint

Dietary Calcium
Intestinal Absorption
Vitamin D
Calcium
Serum
Parathyroid Hormone
Phosphates
Postmenopausal Osteoporosis
Isotopes
Osteoporosis
hydroxide ion

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Intestinal calcium absorption and serum vitamin D metabolites in normal subjects and osteoporotic patients. Effect of age and dietary calcium. / Gallagher, John Christopher G.; Riggs, B. L.; Eisman, J.; Hamstra, A.; Arnaud, S. B.; DeLuca, H. F.

In: Journal of Clinical Investigation, Vol. 64, No. 3, 1979, p. 729-736.

Research output: Contribution to journalArticle

@article{e0eaa91676ba4226afae745b399d1fd3,
title = "Intestinal calcium absorption and serum vitamin D metabolites in normal subjects and osteoporotic patients. Effect of age and dietary calcium",
abstract = "Intestinal calium absorption assessed by a double-isotope method, decreased significantly with aging in 94 normal subjects (r = -0.22, P <0.025). In 52 untreated patients with postmenopausal osteoporosis, calcium absorption was significantly lower than normal when either age or habitual calcium intake was used as a covariable (P <0.001). Serum 25-hydroxyvitamin D (25-OH-D) and 1,25-dihydroxyvitamin D (1,25(OH) 2D) were measured in 44 normal subjects and 27 osteoporotic patients. For all normals, calcium absorption and serum 1,25(OH) 2D were positively correlated (r = 0.50, P <0.001). In nonelderly normal subjects (ages 30-65 yr), dietary calcium intake correlated inversely with both calcium absorption (r = -0.39, P <0.01) and with serum 1,25(OH) 2D (r= -0.5, P <0.01). Both osteoporotic patients and elderly normal subjects (ages 65-90 yr) differed from nonelderly normals in that these correlations were not present. In addition although serum 25-OH-D was normal, serum 1,25(OH) 2D was significantly decreased in both osteoporotic patients and elderly normals (P <0.001). In osteoporotic patients, calcium absorption increased significantly (P <0.001) after 7 d administration of a small dose (0.4 μg/d) of synthetic 1,25(OH) 2D 3. In osteoporotics mean serum immunoreactive parathyroid hormone was either normal (COOH-terminal assay) or low (NH 2-terminal assay) relative to age-matched controls, and mean serum phosphate was increased. The data suggest that inadequate metabolism of 25-OH-D to 1,25(OH) 2D contributes significantly to decreased calcium absorption and adaptation in both osteoporotics and elderly normal subjects. In patients with osteoporosis this abnormality could result from a decrease in factors that normally stimulate 1,25(OH) 2D production, such as the decreased parathyroid hormone secretion and increased serum phosphate demonstrated in this group. In elderly subjects a primary abnormality in metabolism of 25-OH-D to 1,25(OH) 2D, analagous to that seen in aging rats, cannot be excluded.",
author = "Gallagher, {John Christopher G.} and Riggs, {B. L.} and J. Eisman and A. Hamstra and Arnaud, {S. B.} and DeLuca, {H. F.}",
year = "1979",
language = "English",
volume = "64",
pages = "729--736",
journal = "Journal of Clinical Investigation",
issn = "0021-9738",
publisher = "The American Society for Clinical Investigation",
number = "3",

}

TY - JOUR

T1 - Intestinal calcium absorption and serum vitamin D metabolites in normal subjects and osteoporotic patients. Effect of age and dietary calcium

AU - Gallagher, John Christopher G.

AU - Riggs, B. L.

AU - Eisman, J.

AU - Hamstra, A.

AU - Arnaud, S. B.

AU - DeLuca, H. F.

PY - 1979

Y1 - 1979

N2 - Intestinal calium absorption assessed by a double-isotope method, decreased significantly with aging in 94 normal subjects (r = -0.22, P <0.025). In 52 untreated patients with postmenopausal osteoporosis, calcium absorption was significantly lower than normal when either age or habitual calcium intake was used as a covariable (P <0.001). Serum 25-hydroxyvitamin D (25-OH-D) and 1,25-dihydroxyvitamin D (1,25(OH) 2D) were measured in 44 normal subjects and 27 osteoporotic patients. For all normals, calcium absorption and serum 1,25(OH) 2D were positively correlated (r = 0.50, P <0.001). In nonelderly normal subjects (ages 30-65 yr), dietary calcium intake correlated inversely with both calcium absorption (r = -0.39, P <0.01) and with serum 1,25(OH) 2D (r= -0.5, P <0.01). Both osteoporotic patients and elderly normal subjects (ages 65-90 yr) differed from nonelderly normals in that these correlations were not present. In addition although serum 25-OH-D was normal, serum 1,25(OH) 2D was significantly decreased in both osteoporotic patients and elderly normals (P <0.001). In osteoporotic patients, calcium absorption increased significantly (P <0.001) after 7 d administration of a small dose (0.4 μg/d) of synthetic 1,25(OH) 2D 3. In osteoporotics mean serum immunoreactive parathyroid hormone was either normal (COOH-terminal assay) or low (NH 2-terminal assay) relative to age-matched controls, and mean serum phosphate was increased. The data suggest that inadequate metabolism of 25-OH-D to 1,25(OH) 2D contributes significantly to decreased calcium absorption and adaptation in both osteoporotics and elderly normal subjects. In patients with osteoporosis this abnormality could result from a decrease in factors that normally stimulate 1,25(OH) 2D production, such as the decreased parathyroid hormone secretion and increased serum phosphate demonstrated in this group. In elderly subjects a primary abnormality in metabolism of 25-OH-D to 1,25(OH) 2D, analagous to that seen in aging rats, cannot be excluded.

AB - Intestinal calium absorption assessed by a double-isotope method, decreased significantly with aging in 94 normal subjects (r = -0.22, P <0.025). In 52 untreated patients with postmenopausal osteoporosis, calcium absorption was significantly lower than normal when either age or habitual calcium intake was used as a covariable (P <0.001). Serum 25-hydroxyvitamin D (25-OH-D) and 1,25-dihydroxyvitamin D (1,25(OH) 2D) were measured in 44 normal subjects and 27 osteoporotic patients. For all normals, calcium absorption and serum 1,25(OH) 2D were positively correlated (r = 0.50, P <0.001). In nonelderly normal subjects (ages 30-65 yr), dietary calcium intake correlated inversely with both calcium absorption (r = -0.39, P <0.01) and with serum 1,25(OH) 2D (r= -0.5, P <0.01). Both osteoporotic patients and elderly normal subjects (ages 65-90 yr) differed from nonelderly normals in that these correlations were not present. In addition although serum 25-OH-D was normal, serum 1,25(OH) 2D was significantly decreased in both osteoporotic patients and elderly normals (P <0.001). In osteoporotic patients, calcium absorption increased significantly (P <0.001) after 7 d administration of a small dose (0.4 μg/d) of synthetic 1,25(OH) 2D 3. In osteoporotics mean serum immunoreactive parathyroid hormone was either normal (COOH-terminal assay) or low (NH 2-terminal assay) relative to age-matched controls, and mean serum phosphate was increased. The data suggest that inadequate metabolism of 25-OH-D to 1,25(OH) 2D contributes significantly to decreased calcium absorption and adaptation in both osteoporotics and elderly normal subjects. In patients with osteoporosis this abnormality could result from a decrease in factors that normally stimulate 1,25(OH) 2D production, such as the decreased parathyroid hormone secretion and increased serum phosphate demonstrated in this group. In elderly subjects a primary abnormality in metabolism of 25-OH-D to 1,25(OH) 2D, analagous to that seen in aging rats, cannot be excluded.

UR - http://www.scopus.com/inward/record.url?scp=0018672328&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018672328&partnerID=8YFLogxK

M3 - Article

VL - 64

SP - 729

EP - 736

JO - Journal of Clinical Investigation

JF - Journal of Clinical Investigation

SN - 0021-9738

IS - 3

ER -