Abstract
Intestinal calium absorption assessed by a double-isotope method, decreased significantly with aging in 94 normal subjects (r = -0.22, P <0.025). In 52 untreated patients with postmenopausal osteoporosis, calcium absorption was significantly lower than normal when either age or habitual calcium intake was used as a covariable (P <0.001). Serum 25-hydroxyvitamin D (25-OH-D) and 1,25-dihydroxyvitamin D (1,25(OH) 2D) were measured in 44 normal subjects and 27 osteoporotic patients. For all normals, calcium absorption and serum 1,25(OH) 2D were positively correlated (r = 0.50, P <0.001). In nonelderly normal subjects (ages 30-65 yr), dietary calcium intake correlated inversely with both calcium absorption (r = -0.39, P <0.01) and with serum 1,25(OH) 2D (r= -0.5, P <0.01). Both osteoporotic patients and elderly normal subjects (ages 65-90 yr) differed from nonelderly normals in that these correlations were not present. In addition although serum 25-OH-D was normal, serum 1,25(OH) 2D was significantly decreased in both osteoporotic patients and elderly normals (P <0.001). In osteoporotic patients, calcium absorption increased significantly (P <0.001) after 7 d administration of a small dose (0.4 μg/d) of synthetic 1,25(OH) 2D 3. In osteoporotics mean serum immunoreactive parathyroid hormone was either normal (COOH-terminal assay) or low (NH 2-terminal assay) relative to age-matched controls, and mean serum phosphate was increased. The data suggest that inadequate metabolism of 25-OH-D to 1,25(OH) 2D contributes significantly to decreased calcium absorption and adaptation in both osteoporotics and elderly normal subjects. In patients with osteoporosis this abnormality could result from a decrease in factors that normally stimulate 1,25(OH) 2D production, such as the decreased parathyroid hormone secretion and increased serum phosphate demonstrated in this group. In elderly subjects a primary abnormality in metabolism of 25-OH-D to 1,25(OH) 2D, analagous to that seen in aging rats, cannot be excluded.
| Original language | English |
|---|---|
| Pages (from-to) | 729-736 |
| Number of pages | 8 |
| Journal | Journal of Clinical Investigation |
| Volume | 64 |
| Issue number | 3 |
| State | Published - 1979 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
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Intestinal calcium absorption and serum vitamin D metabolites in normal subjects and osteoporotic patients. Effect of age and dietary calcium. / Gallagher, John Christopher G.; Riggs, B. L.; Eisman, J.; Hamstra, A.; Arnaud, S. B.; DeLuca, H. F.
In: Journal of Clinical Investigation, Vol. 64, No. 3, 1979, p. 729-736.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Intestinal calcium absorption and serum vitamin D metabolites in normal subjects and osteoporotic patients. Effect of age and dietary calcium
AU - Gallagher, John Christopher G.
AU - Riggs, B. L.
AU - Eisman, J.
AU - Hamstra, A.
AU - Arnaud, S. B.
AU - DeLuca, H. F.
PY - 1979
Y1 - 1979
N2 - Intestinal calium absorption assessed by a double-isotope method, decreased significantly with aging in 94 normal subjects (r = -0.22, P <0.025). In 52 untreated patients with postmenopausal osteoporosis, calcium absorption was significantly lower than normal when either age or habitual calcium intake was used as a covariable (P <0.001). Serum 25-hydroxyvitamin D (25-OH-D) and 1,25-dihydroxyvitamin D (1,25(OH) 2D) were measured in 44 normal subjects and 27 osteoporotic patients. For all normals, calcium absorption and serum 1,25(OH) 2D were positively correlated (r = 0.50, P <0.001). In nonelderly normal subjects (ages 30-65 yr), dietary calcium intake correlated inversely with both calcium absorption (r = -0.39, P <0.01) and with serum 1,25(OH) 2D (r= -0.5, P <0.01). Both osteoporotic patients and elderly normal subjects (ages 65-90 yr) differed from nonelderly normals in that these correlations were not present. In addition although serum 25-OH-D was normal, serum 1,25(OH) 2D was significantly decreased in both osteoporotic patients and elderly normals (P <0.001). In osteoporotic patients, calcium absorption increased significantly (P <0.001) after 7 d administration of a small dose (0.4 μg/d) of synthetic 1,25(OH) 2D 3. In osteoporotics mean serum immunoreactive parathyroid hormone was either normal (COOH-terminal assay) or low (NH 2-terminal assay) relative to age-matched controls, and mean serum phosphate was increased. The data suggest that inadequate metabolism of 25-OH-D to 1,25(OH) 2D contributes significantly to decreased calcium absorption and adaptation in both osteoporotics and elderly normal subjects. In patients with osteoporosis this abnormality could result from a decrease in factors that normally stimulate 1,25(OH) 2D production, such as the decreased parathyroid hormone secretion and increased serum phosphate demonstrated in this group. In elderly subjects a primary abnormality in metabolism of 25-OH-D to 1,25(OH) 2D, analagous to that seen in aging rats, cannot be excluded.
AB - Intestinal calium absorption assessed by a double-isotope method, decreased significantly with aging in 94 normal subjects (r = -0.22, P <0.025). In 52 untreated patients with postmenopausal osteoporosis, calcium absorption was significantly lower than normal when either age or habitual calcium intake was used as a covariable (P <0.001). Serum 25-hydroxyvitamin D (25-OH-D) and 1,25-dihydroxyvitamin D (1,25(OH) 2D) were measured in 44 normal subjects and 27 osteoporotic patients. For all normals, calcium absorption and serum 1,25(OH) 2D were positively correlated (r = 0.50, P <0.001). In nonelderly normal subjects (ages 30-65 yr), dietary calcium intake correlated inversely with both calcium absorption (r = -0.39, P <0.01) and with serum 1,25(OH) 2D (r= -0.5, P <0.01). Both osteoporotic patients and elderly normal subjects (ages 65-90 yr) differed from nonelderly normals in that these correlations were not present. In addition although serum 25-OH-D was normal, serum 1,25(OH) 2D was significantly decreased in both osteoporotic patients and elderly normals (P <0.001). In osteoporotic patients, calcium absorption increased significantly (P <0.001) after 7 d administration of a small dose (0.4 μg/d) of synthetic 1,25(OH) 2D 3. In osteoporotics mean serum immunoreactive parathyroid hormone was either normal (COOH-terminal assay) or low (NH 2-terminal assay) relative to age-matched controls, and mean serum phosphate was increased. The data suggest that inadequate metabolism of 25-OH-D to 1,25(OH) 2D contributes significantly to decreased calcium absorption and adaptation in both osteoporotics and elderly normal subjects. In patients with osteoporosis this abnormality could result from a decrease in factors that normally stimulate 1,25(OH) 2D production, such as the decreased parathyroid hormone secretion and increased serum phosphate demonstrated in this group. In elderly subjects a primary abnormality in metabolism of 25-OH-D to 1,25(OH) 2D, analagous to that seen in aging rats, cannot be excluded.
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UR - http://www.scopus.com/inward/citedby.url?scp=0018672328&partnerID=8YFLogxK
M3 - Article
C2 - 468987
AN - SCOPUS:0018672328
VL - 64
SP - 729
EP - 736
JO - Journal of Clinical Investigation
JF - Journal of Clinical Investigation
SN - 0021-9738
IS - 3
ER -