Abstract
Pharmacologic doses of corticosteroids impair intestinal calcium absorption and contribute to negative calcium balance. However, the relation between the impaired calcium absorption and a possible defect in the conversion of vitamin D to its physiologically active form, 1,25-dihydrovitamin D, is unknown. The fractional calcium absorption (double-isotope method, 100-mg carrier) and the serum 25-hydroxyvitamin D (25-OH-D) (Haddad method) level were compared in 27 patients receiving pharmacologic doses of prednisone with 27 age-, sex-, and season-matched normal subjects. In patients receiving high daily doses of prednisone (15-100 mg/day), calcium absorption (P3 (0.4 μg daily for 7 days) to patients receiving high-dose corticosteroids led to an increase in calcium absorption in all patients. These results suggest that calcium malabsorption in the corticosteroid-treated patients is due to a dose-related abnormality of vitamin D metabolism and not to a direct effect of corticosteroids on depressing transmucosal intestinal absorption of calcium.
| Original language | English |
|---|---|
| Pages (from-to) | 253-259 |
| Number of pages | 7 |
| Journal | Journal of Clinical Investigation |
| Volume | 60 |
| Issue number | 1 |
| State | Published - 1977 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
Cite this
Intestinal calcium absorption in exogenous hypercortisonism. Role of 25 hydroxyvitamin D and corticosteroid dose. / Klein, R. G.; Arnaud, S. B.; Gallagher, John Christopher G.; Deluca, H. F.; Riggs, B. L.
In: Journal of Clinical Investigation, Vol. 60, No. 1, 1977, p. 253-259.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Intestinal calcium absorption in exogenous hypercortisonism. Role of 25 hydroxyvitamin D and corticosteroid dose
AU - Klein, R. G.
AU - Arnaud, S. B.
AU - Gallagher, John Christopher G.
AU - Deluca, H. F.
AU - Riggs, B. L.
PY - 1977
Y1 - 1977
N2 - Pharmacologic doses of corticosteroids impair intestinal calcium absorption and contribute to negative calcium balance. However, the relation between the impaired calcium absorption and a possible defect in the conversion of vitamin D to its physiologically active form, 1,25-dihydrovitamin D, is unknown. The fractional calcium absorption (double-isotope method, 100-mg carrier) and the serum 25-hydroxyvitamin D (25-OH-D) (Haddad method) level were compared in 27 patients receiving pharmacologic doses of prednisone with 27 age-, sex-, and season-matched normal subjects. In patients receiving high daily doses of prednisone (15-100 mg/day), calcium absorption (P3 (0.4 μg daily for 7 days) to patients receiving high-dose corticosteroids led to an increase in calcium absorption in all patients. These results suggest that calcium malabsorption in the corticosteroid-treated patients is due to a dose-related abnormality of vitamin D metabolism and not to a direct effect of corticosteroids on depressing transmucosal intestinal absorption of calcium.
AB - Pharmacologic doses of corticosteroids impair intestinal calcium absorption and contribute to negative calcium balance. However, the relation between the impaired calcium absorption and a possible defect in the conversion of vitamin D to its physiologically active form, 1,25-dihydrovitamin D, is unknown. The fractional calcium absorption (double-isotope method, 100-mg carrier) and the serum 25-hydroxyvitamin D (25-OH-D) (Haddad method) level were compared in 27 patients receiving pharmacologic doses of prednisone with 27 age-, sex-, and season-matched normal subjects. In patients receiving high daily doses of prednisone (15-100 mg/day), calcium absorption (P3 (0.4 μg daily for 7 days) to patients receiving high-dose corticosteroids led to an increase in calcium absorption in all patients. These results suggest that calcium malabsorption in the corticosteroid-treated patients is due to a dose-related abnormality of vitamin D metabolism and not to a direct effect of corticosteroids on depressing transmucosal intestinal absorption of calcium.
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M3 - Article
VL - 60
SP - 253
EP - 259
JO - Journal of Clinical Investigation
JF - Journal of Clinical Investigation
SN - 0021-9738
IS - 1
ER -