Intra-H-2 recombination in H-2b/H-2t1 heterozygotes in the mouse - II. Characterization of recombinant haplotypes at2, at3, and at4

Kirk Beisel, Pranab K. Haldar, Howard C. Passmore

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Four cases of intra-H-2 recombination were detected during serological screening of 1066 backcross animals produced from H-2b/H-2t1 heterozygous mice. Three of the intra -H-2 recombinants received the K region from H-2t1 and the D region from the H-2b parental chromosome. The remaining recombinant received the K region from the H-2b parental chromosome and the D region from H-2t1. Three of the four recombinants have been developed into inbred lines TBR2, TBR3, and TBR4 and were assigned the haplotype designations at2, at3, and at4. Ss typing revealed that TBR2 and TBR3 originated from K- S interval crossover events, while the remaining two recombinants resulted from crossing over in the S- D interval.

Original languageEnglish
Pages (from-to)405-411
Number of pages7
Issue number1
Publication statusPublished - Dec 1978
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Immunology
  • Genetics

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