Intra-H-2 recombination in H-2b/H-2t1 heterozygotes in the mouse - II. Characterization of recombinant haplotypes at2, at3, and at4

Kirk W. Beisel, Pranab K. Haldar, Howard C. Passmore

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Four cases of intra-H-2 recombination were detected during serological screening of 1066 backcross animals produced from H-2b/H-2t1 heterozygous mice. Three of the intra -H-2 recombinants received the K region from H-2t1 and the D region from the H-2b parental chromosome. The remaining recombinant received the K region from the H-2b parental chromosome and the D region from H-2t1. Three of the four recombinants have been developed into inbred lines TBR2, TBR3, and TBR4 and were assigned the haplotype designations at2, at3, and at4. Ss typing revealed that TBR2 and TBR3 originated from K- S interval crossover events, while the remaining two recombinants resulted from crossing over in the S- D interval.

Original languageEnglish (US)
Pages (from-to)405-411
Number of pages7
JournalImmunogenetics
Volume7
Issue number1
DOIs
StatePublished - Dec 1 1978
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology
  • Genetics

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