Intra‐H‐2 Recombination in H‐2b/H‐2t1 Heterozygotes in the Mouse I. Four Cases of Crossing Over between the S and D Regions

Howard C. Passmore, Kirk W. Beisel

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Abstract

An examination of 1009 backcross animals produced from H-2b/H-2t1 heterozygotes resulted in the detection of four cases of intra-H-2 recombination. Three of the recombinants received the K region from H-2b and the D region from the H-2t1 parental chromosome. The fourth recombinant received a K region from the H-2t1 parental chromosome and the D region from H-2b. Ss typing revealed that crossing occurred between the S and D regions of the H-2 complex in all four cases. Three of the four recombinants were developed into inbred strains and assigned the halotype designations H-218, H-2i9 and H2at1.

Original languageEnglish (US)
Pages (from-to)121-130
Number of pages10
JournalTissue Antigens
Volume9
Issue number2
DOIs
StatePublished - Feb 1977
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Genetics

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