Intravascular forward-looking ultrasound transducers for microbubble-mediated sonothrombolysis

Jinwook Kim, Brooks D. Lindsey, Wei Yi Chang, Xuming Dai, Joseph Stavas, Paul A. Dayton, Xiaoning Jiang

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Effective removal or dissolution of large blood clots remains a challenge in clinical treatment of acute thrombo-occlusive diseases. Here we report the development of an intravascular microbubble-mediated sonothrombolysis device for improving thrombolytic rate and thus minimizing the required dose of thrombolytic drugs. We hypothesize that a sub-megahertz, forward-looking ultrasound transducer with an integrated microbubble injection tube is more advantageous for efficient thrombolysis by enhancing cavitation-induced microstreaming than the conventional high-frequency, side-looking, catheter-mounted transducers. We developed custom miniaturized transducers and demonstrated that these transducers are able to generate sufficient pressure to induce cavitation of lipid-shelled microbubble contrast agents. Our technology demonstrates a thrombolysis rate of 0.7 ± 0.15 percent mass loss/min in vitro without any use of thrombolytic drugs.

Original languageEnglish (US)
Article number3454
JournalScientific Reports
Volume7
Issue number1
DOIs
StatePublished - Dec 1 2017
Externally publishedYes

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Microbubbles
Transducers
Fibrinolytic Agents
Contrast Media
Thrombosis
Catheters
Technology
Lipids
Pressure
Equipment and Supplies
Injections
Therapeutics

All Science Journal Classification (ASJC) codes

  • General

Cite this

Intravascular forward-looking ultrasound transducers for microbubble-mediated sonothrombolysis. / Kim, Jinwook; Lindsey, Brooks D.; Chang, Wei Yi; Dai, Xuming; Stavas, Joseph; Dayton, Paul A.; Jiang, Xiaoning.

In: Scientific Reports, Vol. 7, No. 1, 3454, 01.12.2017.

Research output: Contribution to journalArticle

Kim, Jinwook ; Lindsey, Brooks D. ; Chang, Wei Yi ; Dai, Xuming ; Stavas, Joseph ; Dayton, Paul A. ; Jiang, Xiaoning. / Intravascular forward-looking ultrasound transducers for microbubble-mediated sonothrombolysis. In: Scientific Reports. 2017 ; Vol. 7, No. 1.
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