Intravascular forward-looking ultrasound transducers for microbubble-mediated sonothrombolysis

Jinwook Kim, Brooks D. Lindsey, Wei Yi Chang, Xuming Dai, Joseph Stavas, Paul A. Dayton, Xiaoning Jiang

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Effective removal or dissolution of large blood clots remains a challenge in clinical treatment of acute thrombo-occlusive diseases. Here we report the development of an intravascular microbubble-mediated sonothrombolysis device for improving thrombolytic rate and thus minimizing the required dose of thrombolytic drugs. We hypothesize that a sub-megahertz, forward-looking ultrasound transducer with an integrated microbubble injection tube is more advantageous for efficient thrombolysis by enhancing cavitation-induced microstreaming than the conventional high-frequency, side-looking, catheter-mounted transducers. We developed custom miniaturized transducers and demonstrated that these transducers are able to generate sufficient pressure to induce cavitation of lipid-shelled microbubble contrast agents. Our technology demonstrates a thrombolysis rate of 0.7 ± 0.15 percent mass loss/min in vitro without any use of thrombolytic drugs.

Original languageEnglish (US)
Article number3454
JournalScientific Reports
Volume7
Issue number1
DOIs
StatePublished - Dec 1 2017
Externally publishedYes

All Science Journal Classification (ASJC) codes

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    Kim, J., Lindsey, B. D., Chang, W. Y., Dai, X., Stavas, J., Dayton, P. A., & Jiang, X. (2017). Intravascular forward-looking ultrasound transducers for microbubble-mediated sonothrombolysis. Scientific Reports, 7(1), [3454]. https://doi.org/10.1038/s41598-017-03492-4