Intrinsic material properties of trabecular bone by nanoindentation testing of biopsies taken from healthy women before and after menopause

Benjamin J. Polly, Philip A. Yuya, Mohammed P. Akhter, Robert R. Recker, Joseph A. Turner

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Postmenopausal osteoporosis in women is characterized by an increase in bone fragility and risk of fracture. In addition to transmenopausal decline in three-dimensional trabecular bone architecture, changes in intrinsic material properties (local stiffness, damping, and hardness) may contribute to increased bone fragility. In this study, nanoindentation was used to quantify transmenopausal changes in the intrinsic properties of trabecular bone. Paired transilial biopsy specimens were used from a previously reported study in which bone biopsies were obtained from women prior to menopause (premenopausal, age 49.0 ± 1.9) and at 12 months past the last menstrual period (postmenopausal, age 54.6 ± 2.2). Elastic and viscoelastic material properties of the trabecular bone were measured using quasi-static and dynamic nanoindentation techniques, respectively. Paired Student's t tests (n = 15) were performed to assess the significance of the measured intrinsic properties. Trabecular bone microarchitecture is compromised in postmenopausal women, and although this loss is associated with a trend toward reduction in some intrinsic properties (storage modulus), we found no statistically significant changes in bone intrinsic properties between healthy pre- and postmenopausal biopsies in the quasi-static results and frequency-averaged dynamic results.

Original languageEnglish
Pages (from-to)286-293
Number of pages8
JournalCalcified Tissue International
Volume90
Issue number4
DOIs
StatePublished - Apr 2012

Fingerprint

Menopause
Biopsy
Bone and Bones
Postmenopause
Postmenopausal Osteoporosis
Hardness
Students
Cancellous Bone

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Intrinsic material properties of trabecular bone by nanoindentation testing of biopsies taken from healthy women before and after menopause. / Polly, Benjamin J.; Yuya, Philip A.; Akhter, Mohammed P.; Recker, Robert R.; Turner, Joseph A.

In: Calcified Tissue International, Vol. 90, No. 4, 04.2012, p. 286-293.

Research output: Contribution to journalArticle

@article{44273b7ae18d433f8fc97ebdbaa6650a,
title = "Intrinsic material properties of trabecular bone by nanoindentation testing of biopsies taken from healthy women before and after menopause",
abstract = "Postmenopausal osteoporosis in women is characterized by an increase in bone fragility and risk of fracture. In addition to transmenopausal decline in three-dimensional trabecular bone architecture, changes in intrinsic material properties (local stiffness, damping, and hardness) may contribute to increased bone fragility. In this study, nanoindentation was used to quantify transmenopausal changes in the intrinsic properties of trabecular bone. Paired transilial biopsy specimens were used from a previously reported study in which bone biopsies were obtained from women prior to menopause (premenopausal, age 49.0 ± 1.9) and at 12 months past the last menstrual period (postmenopausal, age 54.6 ± 2.2). Elastic and viscoelastic material properties of the trabecular bone were measured using quasi-static and dynamic nanoindentation techniques, respectively. Paired Student's t tests (n = 15) were performed to assess the significance of the measured intrinsic properties. Trabecular bone microarchitecture is compromised in postmenopausal women, and although this loss is associated with a trend toward reduction in some intrinsic properties (storage modulus), we found no statistically significant changes in bone intrinsic properties between healthy pre- and postmenopausal biopsies in the quasi-static results and frequency-averaged dynamic results.",
author = "Polly, {Benjamin J.} and Yuya, {Philip A.} and Akhter, {Mohammed P.} and Recker, {Robert R.} and Turner, {Joseph A.}",
year = "2012",
month = "4",
doi = "10.1007/s00223-012-9575-8",
language = "English",
volume = "90",
pages = "286--293",
journal = "Calcified Tissue International",
issn = "0171-967X",
publisher = "Springer New York",
number = "4",

}

TY - JOUR

T1 - Intrinsic material properties of trabecular bone by nanoindentation testing of biopsies taken from healthy women before and after menopause

AU - Polly, Benjamin J.

AU - Yuya, Philip A.

AU - Akhter, Mohammed P.

AU - Recker, Robert R.

AU - Turner, Joseph A.

PY - 2012/4

Y1 - 2012/4

N2 - Postmenopausal osteoporosis in women is characterized by an increase in bone fragility and risk of fracture. In addition to transmenopausal decline in three-dimensional trabecular bone architecture, changes in intrinsic material properties (local stiffness, damping, and hardness) may contribute to increased bone fragility. In this study, nanoindentation was used to quantify transmenopausal changes in the intrinsic properties of trabecular bone. Paired transilial biopsy specimens were used from a previously reported study in which bone biopsies were obtained from women prior to menopause (premenopausal, age 49.0 ± 1.9) and at 12 months past the last menstrual period (postmenopausal, age 54.6 ± 2.2). Elastic and viscoelastic material properties of the trabecular bone were measured using quasi-static and dynamic nanoindentation techniques, respectively. Paired Student's t tests (n = 15) were performed to assess the significance of the measured intrinsic properties. Trabecular bone microarchitecture is compromised in postmenopausal women, and although this loss is associated with a trend toward reduction in some intrinsic properties (storage modulus), we found no statistically significant changes in bone intrinsic properties between healthy pre- and postmenopausal biopsies in the quasi-static results and frequency-averaged dynamic results.

AB - Postmenopausal osteoporosis in women is characterized by an increase in bone fragility and risk of fracture. In addition to transmenopausal decline in three-dimensional trabecular bone architecture, changes in intrinsic material properties (local stiffness, damping, and hardness) may contribute to increased bone fragility. In this study, nanoindentation was used to quantify transmenopausal changes in the intrinsic properties of trabecular bone. Paired transilial biopsy specimens were used from a previously reported study in which bone biopsies were obtained from women prior to menopause (premenopausal, age 49.0 ± 1.9) and at 12 months past the last menstrual period (postmenopausal, age 54.6 ± 2.2). Elastic and viscoelastic material properties of the trabecular bone were measured using quasi-static and dynamic nanoindentation techniques, respectively. Paired Student's t tests (n = 15) were performed to assess the significance of the measured intrinsic properties. Trabecular bone microarchitecture is compromised in postmenopausal women, and although this loss is associated with a trend toward reduction in some intrinsic properties (storage modulus), we found no statistically significant changes in bone intrinsic properties between healthy pre- and postmenopausal biopsies in the quasi-static results and frequency-averaged dynamic results.

UR - http://www.scopus.com/inward/record.url?scp=84859889191&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84859889191&partnerID=8YFLogxK

U2 - 10.1007/s00223-012-9575-8

DO - 10.1007/s00223-012-9575-8

M3 - Article

VL - 90

SP - 286

EP - 293

JO - Calcified Tissue International

JF - Calcified Tissue International

SN - 0171-967X

IS - 4

ER -