Ion release and in vitro enamel fluoride uptake associated with pit and assure sealants containing microencapsulated remineralizing agents

Brant D. Burbank, Ryan L. Cooper, Alyssa Kava, Jennifer M. Hartjes, William A. McHale, Mark A. Latta, Stephen Gross

Research output: Contribution to journalArticle

Abstract

Purpose: To determine if pit-and-fissure sealants with microencapsulated remineralizing agents with sustained release of fluoride, calcium and phosphate ions could promote enamel fluoride uptake by demineralized tooth structure. Methods: Sealants that contained 5 w/w% microcapsules with aqueous solutions of 5M Ca(NO3)2 or 0.8M NaF or 6.0M K2HPO4 or a mixture of all three were prepared. Ion release profiles were measured as a function of time. Enamel fluoride uptake by demineralized tooth structure was determined. Results: Sustained release of fluoride, calcium and phosphate ions from a sealant was demonstrated. Fluoride uptake by demineralized enamel was significantly increased compared to a control sealant manufactured without microcapsules (P< 0.01). Bovine enamel that contained 2.2±2.1 μg F/g of enamel prior to exposure to a sealant without microcapsules had 2.3±0.5 after 90 days. Enamel exposed to sealant with 5w/w% NaF microcapsules went from 3.5±3.5 μg F/g of enamel prior to exposure to 148±76 after 90 days. Enamel exposed to sealant with 2 w/w% NaF, 2 w/w% Ca(NO3)2 and 1 w/w% K2HPO4 microcapsules went from 1.7±0.7 μg F/g of enamel prior to exposure to 190±137 after 90 days.

Original languageEnglish (US)
Pages (from-to)59-64
Number of pages6
JournalAmerican Journal of Dentistry
Volume30
Issue number2
StatePublished - Apr 1 2017

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Dental Enamel
Fluorides
Ions
Capsules
Tooth
Pit and Fissure Sealants
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Dentistry(all)

Cite this

Ion release and in vitro enamel fluoride uptake associated with pit and assure sealants containing microencapsulated remineralizing agents. / Burbank, Brant D.; Cooper, Ryan L.; Kava, Alyssa; Hartjes, Jennifer M.; McHale, William A.; Latta, Mark A.; Gross, Stephen.

In: American Journal of Dentistry, Vol. 30, No. 2, 01.04.2017, p. 59-64.

Research output: Contribution to journalArticle

Burbank, Brant D. ; Cooper, Ryan L. ; Kava, Alyssa ; Hartjes, Jennifer M. ; McHale, William A. ; Latta, Mark A. ; Gross, Stephen. / Ion release and in vitro enamel fluoride uptake associated with pit and assure sealants containing microencapsulated remineralizing agents. In: American Journal of Dentistry. 2017 ; Vol. 30, No. 2. pp. 59-64.
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