Isolation of Enterobacter aerogenes susceptible to beta-lactam antibiotics despite high level beta-lactamase production

M. A. Mellencamp; J. S. Roccaforte; L. C. Preheim; C. C. Sanders; C. A. Anene; M. J. Bittner

doi:10.1007/BF01967384

Isolation of Enterobacter aerogenes susceptible to beta-lactam antibiotics despite high level beta-lactamase production

M. A. Mellencamp, J. S. Roccaforte, L. C. Preheim, C. C. Sanders, C. A. Anene, M. J. Bittner

Department of Medicine

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11 Scopus citations

Abstract

This report describes a patient with nosocomial meningitis from whom four distinct isolates of Enterobacter aerogenes were recovered over a complicated course of chemotherapy. The initial isolate was susceptible to expanded spectrum β-lactams despite constitutive production of high levels of β-lactamase. Resistant isolates recovered during antibiotic therapy had lost a 42,000 outer membrane protein. These data suggest that b-lactam susceptibility in the original isolate was due to "hyperpermeability" mediated by the 42,000 Dalton protein.

Original language	English (US)
Pages (from-to)	827-830
Number of pages	4
Journal	European Journal of Clinical Microbiology & Infectious Diseases
Volume	9
Issue number	11
DOIs	https://doi.org/10.1007/BF01967384
State	Published - Nov 1 1990

All Science Journal Classification (ASJC) codes

Microbiology (medical)
Infectious Diseases

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10.1007/BF01967384

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Isolation of Enterobacter aerogenes susceptible to beta-lactam antibiotics despite high level beta-lactamase production. / Mellencamp, M. A.; Roccaforte, J. S.; Preheim, L. C.; Sanders, C. C.; Anene, C. A.; Bittner, M. J.

In: European Journal of Clinical Microbiology & Infectious Diseases, Vol. 9, No. 11, 01.11.1990, p. 827-830.

Research output: Contribution to journal › Article › peer-review

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AU - Sanders, C. C.

AU - Anene, C. A.

AU - Bittner, M. J.

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AB - This report describes a patient with nosocomial meningitis from whom four distinct isolates of Enterobacter aerogenes were recovered over a complicated course of chemotherapy. The initial isolate was susceptible to expanded spectrum β-lactams despite constitutive production of high levels of β-lactamase. Resistant isolates recovered during antibiotic therapy had lost a 42,000 outer membrane protein. These data suggest that b-lactam susceptibility in the original isolate was due to "hyperpermeability" mediated by the 42,000 Dalton protein.

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Isolation of Enterobacter aerogenes susceptible to beta-lactam antibiotics despite high level beta-lactamase production

Abstract

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