Abstract
This report describes a patient with nosocomial meningitis from whom four distinct isolates of Enterobacter aerogenes were recovered over a complicated course of chemotherapy. The initial isolate was susceptible to expanded spectrum β-lactams despite constitutive production of high levels of β-lactamase. Resistant isolates recovered during antibiotic therapy had lost a 42,000 outer membrane protein. These data suggest that b-lactam susceptibility in the original isolate was due to "hyperpermeability" mediated by the 42,000 Dalton protein.
Original language | English (US) |
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Pages (from-to) | 827-830 |
Number of pages | 4 |
Journal | European Journal of Clinical Microbiology & Infectious Diseases |
Volume | 9 |
Issue number | 11 |
DOIs | |
State | Published - Nov 1 1990 |
All Science Journal Classification (ASJC) codes
- Microbiology (medical)
- Infectious Diseases