Isolation of Enterobacter aerogenes susceptible to beta-lactam antibiotics despite high level beta-lactamase production

M. A. Mellencamp, J. S. Roccaforte, L. C. Preheim, C. C. Sanders, C. A. Anene, M. J. Bittner

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This report describes a patient with nosocomial meningitis from whom four distinct isolates of Enterobacter aerogenes were recovered over a complicated course of chemotherapy. The initial isolate was susceptible to expanded spectrum β-lactams despite constitutive production of high levels of β-lactamase. Resistant isolates recovered during antibiotic therapy had lost a 42,000 outer membrane protein. These data suggest that b-lactam susceptibility in the original isolate was due to "hyperpermeability" mediated by the 42,000 Dalton protein.

Original languageEnglish (US)
Pages (from-to)827-830
Number of pages4
JournalEuropean Journal of Clinical Microbiology & Infectious Diseases
Issue number11
StatePublished - Nov 1 1990


All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

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