This report describes a patient with nosocomial meningitis from whom four distinct isolates of Enterobacter aerogenes were recovered over a complicated course of chemotherapy. The initial isolate was susceptible to expanded spectrum β-lactams despite constitutive production of high levels of β-lactamase. Resistant isolates recovered during antibiotic therapy had lost a 42,000 outer membrane protein. These data suggest that b-lactam susceptibility in the original isolate was due to "hyperpermeability" mediated by the 42,000 Dalton protein.
|Original language||English (US)|
|Number of pages||4|
|Journal||European Journal of Clinical Microbiology & Infectious Diseases|
|State||Published - Nov 1 1990|
All Science Journal Classification (ASJC) codes
- Microbiology (medical)
- Infectious Diseases