Isoprostanes and neuroprostanes: Total synthesis, biological activity and biomarkers of oxidative stress in humans

Jean Marie Galano, Emilie Mas, Anne Barden, Trevor A. Mori, Cinzia Signorini, Claudio De Felice, Aaron Barrett, Catherine Opere, Edith Pinot, Edzard Schwedhelm, Ralf Benndorf, Jérôme Roy, Jean Yves Le Guennec, Camille Oger, Thierry Durand

Research output: Contribution to journalReview article

56 Scopus citations

Abstract

Isoprostanes (IsoPs) and neuroprostanes (NeuroPs) are formed in vivo by a free radical non-enzymatic mechanism involving peroxidation of arachidonic acid (AA, C20:4 n-6) and docosahexaenoic acid (DHA, C22:6 n-3) respectively. This review summarises our research in the total synthesis of these lipid metabolites, as well as their biological activities and their utility as biomarkers of oxidative stress in humans.

Original languageEnglish (US)
Pages (from-to)95-102
Number of pages8
JournalProstaglandins and Other Lipid Mediators
Volume107
DOIs
StatePublished - May 27 2013

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Pharmacology
  • Cell Biology

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    Galano, J. M., Mas, E., Barden, A., Mori, T. A., Signorini, C., De Felice, C., Barrett, A., Opere, C., Pinot, E., Schwedhelm, E., Benndorf, R., Roy, J., Le Guennec, J. Y., Oger, C., & Durand, T. (2013). Isoprostanes and neuroprostanes: Total synthesis, biological activity and biomarkers of oxidative stress in humans. Prostaglandins and Other Lipid Mediators, 107, 95-102. https://doi.org/10.1016/j.prostaglandins.2013.04.003