Abstract
Isoprostanes (IsoPs) and neuroprostanes (NeuroPs) are formed in vivo by a free radical non-enzymatic mechanism involving peroxidation of arachidonic acid (AA, C20:4 n-6) and docosahexaenoic acid (DHA, C22:6 n-3) respectively. This review summarises our research in the total synthesis of these lipid metabolites, as well as their biological activities and their utility as biomarkers of oxidative stress in humans.
Original language | English (US) |
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Pages (from-to) | 95-102 |
Number of pages | 8 |
Journal | Prostaglandins and Other Lipid Mediators |
Volume | 107 |
DOIs | |
State | Published - 2013 |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Physiology
- Pharmacology
- Cell Biology