Isoprostanes and neuroprostanes: Total synthesis, biological activity and biomarkers of oxidative stress in humans

Jean Marie Galano; Emilie Mas; Anne Barden; Trevor A. Mori; Cinzia Signorini; Claudio De Felice; Aaron Barrett; Catherine Opere; Edith Pinot; Edzard Schwedhelm; Ralf Benndorf; Jérôme Roy; Jean Yves Le Guennec; Camille Oger; Thierry Durand

doi:10.1016/j.prostaglandins.2013.04.003

Isoprostanes and neuroprostanes: Total synthesis, biological activity and biomarkers of oxidative stress in humans

Jean Marie Galano, Emilie Mas, Anne Barden, Trevor A. Mori, Cinzia Signorini, Claudio De Felice, Aaron Barrett, Catherine Opere, Edith Pinot, Edzard Schwedhelm, Ralf Benndorf, Jérôme Roy, Jean Yves Le Guennec, Camille Oger, Thierry Durand

Department of Pharmacy Sciences

Research output: Contribution to journal › Review article

56 Scopus citations

Abstract

Isoprostanes (IsoPs) and neuroprostanes (NeuroPs) are formed in vivo by a free radical non-enzymatic mechanism involving peroxidation of arachidonic acid (AA, C20:4 n-6) and docosahexaenoic acid (DHA, C22:6 n-3) respectively. This review summarises our research in the total synthesis of these lipid metabolites, as well as their biological activities and their utility as biomarkers of oxidative stress in humans.

Original language	English (US)
Pages (from-to)	95-102
Number of pages	8
Journal	Prostaglandins and Other Lipid Mediators
Volume	107
DOIs	https://doi.org/10.1016/j.prostaglandins.2013.04.003
State	Published - May 27 2013

All Science Journal Classification (ASJC) codes

Biochemistry
Physiology
Pharmacology
Cell Biology

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Galano, J. M., Mas, E., Barden, A., Mori, T. A., Signorini, C., De Felice, C., Barrett, A., Opere, C., Pinot, E., Schwedhelm, E., Benndorf, R., Roy, J., Le Guennec, J. Y., Oger, C., & Durand, T. (2013). Isoprostanes and neuroprostanes: Total synthesis, biological activity and biomarkers of oxidative stress in humans. Prostaglandins and Other Lipid Mediators, 107, 95-102. https://doi.org/10.1016/j.prostaglandins.2013.04.003

Isoprostanes and neuroprostanes : Total synthesis, biological activity and biomarkers of oxidative stress in humans. / Galano, Jean Marie; Mas, Emilie; Barden, Anne; Mori, Trevor A.; Signorini, Cinzia; De Felice, Claudio; Barrett, Aaron; Opere, Catherine; Pinot, Edith; Schwedhelm, Edzard; Benndorf, Ralf; Roy, Jérôme; Le Guennec, Jean Yves; Oger, Camille; Durand, Thierry.

In: Prostaglandins and Other Lipid Mediators, Vol. 107, 27.05.2013, p. 95-102.

Research output: Contribution to journal › Review article

Galano, JM, Mas, E, Barden, A, Mori, TA, Signorini, C, De Felice, C, Barrett, A, Opere, C, Pinot, E, Schwedhelm, E, Benndorf, R, Roy, J, Le Guennec, JY, Oger, C & Durand, T 2013, 'Isoprostanes and neuroprostanes: Total synthesis, biological activity and biomarkers of oxidative stress in humans', Prostaglandins and Other Lipid Mediators, vol. 107, pp. 95-102. https://doi.org/10.1016/j.prostaglandins.2013.04.003

Galano, Jean Marie ; Mas, Emilie ; Barden, Anne ; Mori, Trevor A. ; Signorini, Cinzia ; De Felice, Claudio ; Barrett, Aaron ; Opere, Catherine ; Pinot, Edith ; Schwedhelm, Edzard ; Benndorf, Ralf ; Roy, Jérôme ; Le Guennec, Jean Yves ; Oger, Camille ; Durand, Thierry. / Isoprostanes and neuroprostanes : Total synthesis, biological activity and biomarkers of oxidative stress in humans. In: Prostaglandins and Other Lipid Mediators. 2013 ; Vol. 107. pp. 95-102.

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