Isoprostanes and neuroprostanes: Total synthesis, biological activity and biomarkers of oxidative stress in humans

Jean Marie Galano; Emilie Mas; Anne Barden; Trevor A. Mori; Cinzia Signorini; Claudio De Felice; Aaron Barrett; Catherine Opere; Edith Pinot; Edzard Schwedhelm; Ralf Benndorf; Jérôme Roy; Jean Yves Le Guennec; Camille Oger; Thierry Durand

doi:10.1016/j.prostaglandins.2013.04.003

Isoprostanes and neuroprostanes: Total synthesis, biological activity and biomarkers of oxidative stress in humans

Jean Marie Galano, Emilie Mas, Anne Barden, Trevor A. Mori, Cinzia Signorini, Claudio De Felice, Aaron Barrett, Catherine Opere, Edith Pinot, Edzard Schwedhelm, Ralf Benndorf, Jérôme Roy, Jean Yves Le Guennec, Camille Oger, Thierry Durand

Department of Pharmacy Sciences

Research output: Contribution to journal › Review article › peer-review

66 Scopus citations

Abstract

Isoprostanes (IsoPs) and neuroprostanes (NeuroPs) are formed in vivo by a free radical non-enzymatic mechanism involving peroxidation of arachidonic acid (AA, C20:4 n-6) and docosahexaenoic acid (DHA, C22:6 n-3) respectively. This review summarises our research in the total synthesis of these lipid metabolites, as well as their biological activities and their utility as biomarkers of oxidative stress in humans.

Original language	English (US)
Pages (from-to)	95-102
Number of pages	8
Journal	Prostaglandins and Other Lipid Mediators
Volume	107
DOIs	https://doi.org/10.1016/j.prostaglandins.2013.04.003
State	Published - 2013

All Science Journal Classification (ASJC) codes

Biochemistry
Physiology
Pharmacology
Cell Biology

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Galano, J. M., Mas, E., Barden, A., Mori, T. A., Signorini, C., De Felice, C., Barrett, A., Opere, C., Pinot, E., Schwedhelm, E., Benndorf, R., Roy, J., Le Guennec, J. Y., Oger, C., & Durand, T. (2013). Isoprostanes and neuroprostanes: Total synthesis, biological activity and biomarkers of oxidative stress in humans. Prostaglandins and Other Lipid Mediators, 107, 95-102. https://doi.org/10.1016/j.prostaglandins.2013.04.003

Galano, JM, Mas, E, Barden, A, Mori, TA, Signorini, C, De Felice, C, Barrett, A, Opere, C, Pinot, E, Schwedhelm, E, Benndorf, R, Roy, J, Le Guennec, JY, Oger, C & Durand, T 2013, 'Isoprostanes and neuroprostanes: Total synthesis, biological activity and biomarkers of oxidative stress in humans', Prostaglandins and Other Lipid Mediators, vol. 107, pp. 95-102. https://doi.org/10.1016/j.prostaglandins.2013.04.003

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title = "Isoprostanes and neuroprostanes: Total synthesis, biological activity and biomarkers of oxidative stress in humans",

abstract = "Isoprostanes (IsoPs) and neuroprostanes (NeuroPs) are formed in vivo by a free radical non-enzymatic mechanism involving peroxidation of arachidonic acid (AA, C20:4 n-6) and docosahexaenoic acid (DHA, C22:6 n-3) respectively. This review summarises our research in the total synthesis of these lipid metabolites, as well as their biological activities and their utility as biomarkers of oxidative stress in humans.",

author = "Galano, {Jean Marie} and Emilie Mas and Anne Barden and Mori, {Trevor A.} and Cinzia Signorini and {De Felice}, Claudio and Aaron Barrett and Catherine Opere and Edith Pinot and Edzard Schwedhelm and Ralf Benndorf and J{\'e}r{\^o}me Roy and {Le Guennec}, {Jean Yves} and Camille Oger and Thierry Durand",

year = "2013",

doi = "10.1016/j.prostaglandins.2013.04.003",

language = "English (US)",

volume = "107",

pages = "95--102",

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issn = "1098-8823",

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T1 - Isoprostanes and neuroprostanes

T2 - Total synthesis, biological activity and biomarkers of oxidative stress in humans

AU - Galano, Jean Marie

AU - Mas, Emilie

AU - Barden, Anne

AU - Mori, Trevor A.

AU - Signorini, Cinzia

AU - De Felice, Claudio

AU - Barrett, Aaron

AU - Opere, Catherine

AU - Pinot, Edith

AU - Schwedhelm, Edzard

AU - Benndorf, Ralf

AU - Roy, Jérôme

AU - Le Guennec, Jean Yves

AU - Oger, Camille

AU - Durand, Thierry

PY - 2013

Y1 - 2013

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AB - Isoprostanes (IsoPs) and neuroprostanes (NeuroPs) are formed in vivo by a free radical non-enzymatic mechanism involving peroxidation of arachidonic acid (AA, C20:4 n-6) and docosahexaenoic acid (DHA, C22:6 n-3) respectively. This review summarises our research in the total synthesis of these lipid metabolites, as well as their biological activities and their utility as biomarkers of oxidative stress in humans.

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Isoprostanes and neuroprostanes: Total synthesis, biological activity and biomarkers of oxidative stress in humans

Abstract

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