IV chenodeoxycholate prevents calcium bilirubinate gallstones during total parenteral nutrition in the prairie dog

George Broughton, Robert Joseph Fitzgibbons, Roger W. Geiss, Thomas E. Adrian, Gary Anthone

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: The purpose of this study was to determine whether IV chenodeoxycholate (CDC) could prevent total parenteral nutrition (TPN)- associated pigmented gallstones in the prairie dog. Methods: Twelve prairie dogs were divided into two equal groups, each receiving an identical TPN regimen. Each animal received 92 kcal/d with 61% of the calories from carbohydrate. The total volume of infusate delivered to each animal was 59 mL/d. Animals in one group, termed the TPN + CDC group, received a dally bolus injection of CDC at a dose of 15 mg/kg. Prairie dogs in the second group, termed the TPN group, received water (vehicle carrier) 1 mL/kg/d. The TPN and TPN + CDC groups received TPN for 40.3 ± 1.3 and 42.5 ± 0.6 days, respectively. Results: There was no statistical difference in the initial and final weights between the two groups. None of the TPN + CDC-treated animals had gallstones or calcium bilirubinate crystals. In contrast, all of the TPN- treated animals had calcium bilirubinate crystals (p = .002), and five of six had macroscopic black pigmented gallstones (p = .015). Cholesterol crystals were not observed in either group of animals. The amount of biliary bilirubin and ionized calcium was significantly greater in the TPN group (both p <.001); however, both groups had a similar total biliary calcium concentration. Conclusion: IV CDC is effective in preventing TPN-associated gallstones in the prairie dog.

Original languageEnglish
Pages (from-to)187-193
Number of pages7
JournalJournal of Parenteral and Enteral Nutrition
Volume20
Issue number3
StatePublished - 1996

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Chenodeoxycholic Acid
cholelithiasis
Cynomys
Sciuridae
Total Parenteral Nutrition
total parenteral nutrition
Gallstones
Bilirubin
calcium
crystals
animals
Calcium
bilirubin
Cholesterol
Carbohydrates
cholesterol

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Food Science

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IV chenodeoxycholate prevents calcium bilirubinate gallstones during total parenteral nutrition in the prairie dog. / Broughton, George; Fitzgibbons, Robert Joseph; Geiss, Roger W.; Adrian, Thomas E.; Anthone, Gary.

In: Journal of Parenteral and Enteral Nutrition, Vol. 20, No. 3, 1996, p. 187-193.

Research output: Contribution to journalArticle

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abstract = "Background: The purpose of this study was to determine whether IV chenodeoxycholate (CDC) could prevent total parenteral nutrition (TPN)- associated pigmented gallstones in the prairie dog. Methods: Twelve prairie dogs were divided into two equal groups, each receiving an identical TPN regimen. Each animal received 92 kcal/d with 61{\%} of the calories from carbohydrate. The total volume of infusate delivered to each animal was 59 mL/d. Animals in one group, termed the TPN + CDC group, received a dally bolus injection of CDC at a dose of 15 mg/kg. Prairie dogs in the second group, termed the TPN group, received water (vehicle carrier) 1 mL/kg/d. The TPN and TPN + CDC groups received TPN for 40.3 ± 1.3 and 42.5 ± 0.6 days, respectively. Results: There was no statistical difference in the initial and final weights between the two groups. None of the TPN + CDC-treated animals had gallstones or calcium bilirubinate crystals. In contrast, all of the TPN- treated animals had calcium bilirubinate crystals (p = .002), and five of six had macroscopic black pigmented gallstones (p = .015). Cholesterol crystals were not observed in either group of animals. The amount of biliary bilirubin and ionized calcium was significantly greater in the TPN group (both p <.001); however, both groups had a similar total biliary calcium concentration. Conclusion: IV CDC is effective in preventing TPN-associated gallstones in the prairie dog.",
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AU - Adrian, Thomas E.

AU - Anthone, Gary

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N2 - Background: The purpose of this study was to determine whether IV chenodeoxycholate (CDC) could prevent total parenteral nutrition (TPN)- associated pigmented gallstones in the prairie dog. Methods: Twelve prairie dogs were divided into two equal groups, each receiving an identical TPN regimen. Each animal received 92 kcal/d with 61% of the calories from carbohydrate. The total volume of infusate delivered to each animal was 59 mL/d. Animals in one group, termed the TPN + CDC group, received a dally bolus injection of CDC at a dose of 15 mg/kg. Prairie dogs in the second group, termed the TPN group, received water (vehicle carrier) 1 mL/kg/d. The TPN and TPN + CDC groups received TPN for 40.3 ± 1.3 and 42.5 ± 0.6 days, respectively. Results: There was no statistical difference in the initial and final weights between the two groups. None of the TPN + CDC-treated animals had gallstones or calcium bilirubinate crystals. In contrast, all of the TPN- treated animals had calcium bilirubinate crystals (p = .002), and five of six had macroscopic black pigmented gallstones (p = .015). Cholesterol crystals were not observed in either group of animals. The amount of biliary bilirubin and ionized calcium was significantly greater in the TPN group (both p <.001); however, both groups had a similar total biliary calcium concentration. Conclusion: IV CDC is effective in preventing TPN-associated gallstones in the prairie dog.

AB - Background: The purpose of this study was to determine whether IV chenodeoxycholate (CDC) could prevent total parenteral nutrition (TPN)- associated pigmented gallstones in the prairie dog. Methods: Twelve prairie dogs were divided into two equal groups, each receiving an identical TPN regimen. Each animal received 92 kcal/d with 61% of the calories from carbohydrate. The total volume of infusate delivered to each animal was 59 mL/d. Animals in one group, termed the TPN + CDC group, received a dally bolus injection of CDC at a dose of 15 mg/kg. Prairie dogs in the second group, termed the TPN group, received water (vehicle carrier) 1 mL/kg/d. The TPN and TPN + CDC groups received TPN for 40.3 ± 1.3 and 42.5 ± 0.6 days, respectively. Results: There was no statistical difference in the initial and final weights between the two groups. None of the TPN + CDC-treated animals had gallstones or calcium bilirubinate crystals. In contrast, all of the TPN- treated animals had calcium bilirubinate crystals (p = .002), and five of six had macroscopic black pigmented gallstones (p = .015). Cholesterol crystals were not observed in either group of animals. The amount of biliary bilirubin and ionized calcium was significantly greater in the TPN group (both p <.001); however, both groups had a similar total biliary calcium concentration. Conclusion: IV CDC is effective in preventing TPN-associated gallstones in the prairie dog.

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