Abstract
We examined the effect of ketotifen on the down-regulation of beta-adrenoceptors in guinea pig lung chronically treated with terbutaline. There was a significant decrease in the density of beta-adrenoceptors following chronic administration of terbutaline. Ketotifen prevented the decrease in beta-adrenoceptor density induced by terbutaline in a dose-dependent fashion; ketotifen alone, also increased the density of beta-adrenoceptors. However, neither ketotifen nor terbutaline significantly changed the KD values in either group. These findings suggest that ketotifen might be valuable when beta-agonists are administered for long term treatment in asthmatic patients.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1221-1227 |
| Number of pages | 7 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 152 |
| Issue number | 3 |
| DOIs | |
| State | Published - May 16 1988 |
All Science Journal Classification (ASJC) codes
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology
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Koshino, T., Agrawal, D. K., Townley, T. A., & Townley, R. G. (1988). Ketotifen prevents terbutaline-induced down-regulation of beta-adrenoceptors in Guinea pig lung. Biochemical and Biophysical Research Communications, 152(3), 1221-1227. https://doi.org/10.1016/S0006-291X(88)80415-7