Abstract
We examined the effect of ketotifen on the down-regulation of beta-adrenoceptors in guinea pig lung chronically treated with terbutaline. There was a significant decrease in the density of beta-adrenoceptors following chronic administration of terbutaline. Ketotifen prevented the decrease in beta-adrenoceptor density induced by terbutaline in a dose-dependent fashion; ketotifen alone, also increased the density of beta-adrenoceptors. However, neither ketotifen nor terbutaline significantly changed the KD values in either group. These findings suggest that ketotifen might be valuable when beta-agonists are administered for long term treatment in asthmatic patients.
| Original language | English |
|---|---|
| Pages (from-to) | 1221-1227 |
| Number of pages | 7 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 152 |
| Issue number | 3 |
| DOIs | |
| State | Published - May 16 1988 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Biophysics
- Molecular Biology
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Ketotifen prevents terbutaline-induced down-regulation of beta-adrenoceptors in Guinea pig lung. / Koshino, T.; Agrawal, Devendra K.; Townley, T. A.; Townley, R. G.
In: Biochemical and Biophysical Research Communications, Vol. 152, No. 3, 16.05.1988, p. 1221-1227.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ketotifen prevents terbutaline-induced down-regulation of beta-adrenoceptors in Guinea pig lung
AU - Koshino, T.
AU - Agrawal, Devendra K.
AU - Townley, T. A.
AU - Townley, R. G.
PY - 1988/5/16
Y1 - 1988/5/16
N2 - We examined the effect of ketotifen on the down-regulation of beta-adrenoceptors in guinea pig lung chronically treated with terbutaline. There was a significant decrease in the density of beta-adrenoceptors following chronic administration of terbutaline. Ketotifen prevented the decrease in beta-adrenoceptor density induced by terbutaline in a dose-dependent fashion; ketotifen alone, also increased the density of beta-adrenoceptors. However, neither ketotifen nor terbutaline significantly changed the KD values in either group. These findings suggest that ketotifen might be valuable when beta-agonists are administered for long term treatment in asthmatic patients.
AB - We examined the effect of ketotifen on the down-regulation of beta-adrenoceptors in guinea pig lung chronically treated with terbutaline. There was a significant decrease in the density of beta-adrenoceptors following chronic administration of terbutaline. Ketotifen prevented the decrease in beta-adrenoceptor density induced by terbutaline in a dose-dependent fashion; ketotifen alone, also increased the density of beta-adrenoceptors. However, neither ketotifen nor terbutaline significantly changed the KD values in either group. These findings suggest that ketotifen might be valuable when beta-agonists are administered for long term treatment in asthmatic patients.
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UR - http://www.scopus.com/inward/citedby.url?scp=0023936869&partnerID=8YFLogxK
U2 - 10.1016/S0006-291X(88)80415-7
DO - 10.1016/S0006-291X(88)80415-7
M3 - Article
VL - 152
SP - 1221
EP - 1227
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 3
ER -