Ketotifen prevents terbutaline-induced down-regulation of beta-adrenoceptors in Guinea pig lung

T. Koshino; D. K. Agrawal; T. A. Townley; R. G. Townley

doi:10.1016/S0006-291X(88)80415-7

Ketotifen prevents terbutaline-induced down-regulation of beta-adrenoceptors in Guinea pig lung

T. Koshino, D. K. Agrawal, T. A. Townley, R. G. Townley

Department of Medicine

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

We examined the effect of ketotifen on the down-regulation of beta-adrenoceptors in guinea pig lung chronically treated with terbutaline. There was a significant decrease in the density of beta-adrenoceptors following chronic administration of terbutaline. Ketotifen prevented the decrease in beta-adrenoceptor density induced by terbutaline in a dose-dependent fashion; ketotifen alone, also increased the density of beta-adrenoceptors. However, neither ketotifen nor terbutaline significantly changed the K_D values in either group. These findings suggest that ketotifen might be valuable when beta-agonists are administered for long term treatment in asthmatic patients.

Original language	English (US)
Pages (from-to)	1221-1227
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	152
Issue number	3
DOIs	https://doi.org/10.1016/S0006-291X(88)80415-7
State	Published - May 16 1988

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Molecular Biology
Cell Biology

Access to Document

10.1016/S0006-291X(88)80415-7

Fingerprint Dive into the research topics of 'Ketotifen prevents terbutaline-induced down-regulation of beta-adrenoceptors in Guinea pig lung'. Together they form a unique fingerprint.

Cite this

@article{21a7e54b86bf49289ed3c8c4a8b77a20,

title = "Ketotifen prevents terbutaline-induced down-regulation of beta-adrenoceptors in Guinea pig lung",

abstract = "We examined the effect of ketotifen on the down-regulation of beta-adrenoceptors in guinea pig lung chronically treated with terbutaline. There was a significant decrease in the density of beta-adrenoceptors following chronic administration of terbutaline. Ketotifen prevented the decrease in beta-adrenoceptor density induced by terbutaline in a dose-dependent fashion; ketotifen alone, also increased the density of beta-adrenoceptors. However, neither ketotifen nor terbutaline significantly changed the KD values in either group. These findings suggest that ketotifen might be valuable when beta-agonists are administered for long term treatment in asthmatic patients.",

author = "T. Koshino and Agrawal, {D. K.} and Townley, {T. A.} and Townley, {R. G.}",

note = "Funding Information: We would like to thank Mrs. Rosemary Batts for preparing this manuscript. This work was supported by a grant from the Sandoz Research Institute, East Hanover, New Jersey. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

year = "1988",

month = may,

day = "16",

doi = "10.1016/S0006-291X(88)80415-7",

language = "English (US)",

volume = "152",

pages = "1221--1227",

journal = "Biochemical and Biophysical Research Communications",

issn = "0006-291X",

publisher = "Academic Press Inc.",

number = "3",

}

TY - JOUR

T1 - Ketotifen prevents terbutaline-induced down-regulation of beta-adrenoceptors in Guinea pig lung

AU - Koshino, T.

AU - Agrawal, D. K.

AU - Townley, T. A.

AU - Townley, R. G.

N1 - Funding Information: We would like to thank Mrs. Rosemary Batts for preparing this manuscript. This work was supported by a grant from the Sandoz Research Institute, East Hanover, New Jersey. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 1988/5/16

Y1 - 1988/5/16

N2 - We examined the effect of ketotifen on the down-regulation of beta-adrenoceptors in guinea pig lung chronically treated with terbutaline. There was a significant decrease in the density of beta-adrenoceptors following chronic administration of terbutaline. Ketotifen prevented the decrease in beta-adrenoceptor density induced by terbutaline in a dose-dependent fashion; ketotifen alone, also increased the density of beta-adrenoceptors. However, neither ketotifen nor terbutaline significantly changed the KD values in either group. These findings suggest that ketotifen might be valuable when beta-agonists are administered for long term treatment in asthmatic patients.

AB - We examined the effect of ketotifen on the down-regulation of beta-adrenoceptors in guinea pig lung chronically treated with terbutaline. There was a significant decrease in the density of beta-adrenoceptors following chronic administration of terbutaline. Ketotifen prevented the decrease in beta-adrenoceptor density induced by terbutaline in a dose-dependent fashion; ketotifen alone, also increased the density of beta-adrenoceptors. However, neither ketotifen nor terbutaline significantly changed the KD values in either group. These findings suggest that ketotifen might be valuable when beta-agonists are administered for long term treatment in asthmatic patients.

UR - http://www.scopus.com/inward/record.url?scp=0023936869&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023936869&partnerID=8YFLogxK

U2 - 10.1016/S0006-291X(88)80415-7

DO - 10.1016/S0006-291X(88)80415-7

M3 - Article

C2 - 2897844

AN - SCOPUS:0023936869

VL - 152

SP - 1221

EP - 1227

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

IS - 3

ER -

Ketotifen prevents terbutaline-induced down-regulation of beta-adrenoceptors in Guinea pig lung

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Cite this