Ketotifen prevents terbutaline-induced down-regulation of beta-adrenoceptors in Guinea pig lung

T. Koshino; D. K. Agrawal; T. A. Townley; R. G. Townley

doi:10.1016/S0006-291X(88)80415-7

Ketotifen prevents terbutaline-induced down-regulation of beta-adrenoceptors in Guinea pig lung

T. Koshino, D. K. Agrawal, T. A. Townley, R. G. Townley

Department of Medicine

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

We examined the effect of ketotifen on the down-regulation of beta-adrenoceptors in guinea pig lung chronically treated with terbutaline. There was a significant decrease in the density of beta-adrenoceptors following chronic administration of terbutaline. Ketotifen prevented the decrease in beta-adrenoceptor density induced by terbutaline in a dose-dependent fashion; ketotifen alone, also increased the density of beta-adrenoceptors. However, neither ketotifen nor terbutaline significantly changed the K_D values in either group. These findings suggest that ketotifen might be valuable when beta-agonists are administered for long term treatment in asthmatic patients.

Original language	English (US)
Pages (from-to)	1221-1227
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	152
Issue number	3
DOIs	https://doi.org/10.1016/S0006-291X(88)80415-7
State	Published - May 16 1988

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/S0006-291X(88)80415-7

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title = "Ketotifen prevents terbutaline-induced down-regulation of beta-adrenoceptors in Guinea pig lung",

abstract = "We examined the effect of ketotifen on the down-regulation of beta-adrenoceptors in guinea pig lung chronically treated with terbutaline. There was a significant decrease in the density of beta-adrenoceptors following chronic administration of terbutaline. Ketotifen prevented the decrease in beta-adrenoceptor density induced by terbutaline in a dose-dependent fashion; ketotifen alone, also increased the density of beta-adrenoceptors. However, neither ketotifen nor terbutaline significantly changed the KD values in either group. These findings suggest that ketotifen might be valuable when beta-agonists are administered for long term treatment in asthmatic patients.",

author = "T. Koshino and Agrawal, {D. K.} and Townley, {T. A.} and Townley, {R. G.}",

note = "Funding Information: We would like to thank Mrs. Rosemary Batts for preparing this manuscript. This work was supported by a grant from the Sandoz Research Institute, East Hanover, New Jersey. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

year = "1988",

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doi = "10.1016/S0006-291X(88)80415-7",

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T1 - Ketotifen prevents terbutaline-induced down-regulation of beta-adrenoceptors in Guinea pig lung

AU - Koshino, T.

AU - Agrawal, D. K.

AU - Townley, T. A.

AU - Townley, R. G.

N1 - Funding Information: We would like to thank Mrs. Rosemary Batts for preparing this manuscript. This work was supported by a grant from the Sandoz Research Institute, East Hanover, New Jersey. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 1988/5/16

Y1 - 1988/5/16

N2 - We examined the effect of ketotifen on the down-regulation of beta-adrenoceptors in guinea pig lung chronically treated with terbutaline. There was a significant decrease in the density of beta-adrenoceptors following chronic administration of terbutaline. Ketotifen prevented the decrease in beta-adrenoceptor density induced by terbutaline in a dose-dependent fashion; ketotifen alone, also increased the density of beta-adrenoceptors. However, neither ketotifen nor terbutaline significantly changed the KD values in either group. These findings suggest that ketotifen might be valuable when beta-agonists are administered for long term treatment in asthmatic patients.

AB - We examined the effect of ketotifen on the down-regulation of beta-adrenoceptors in guinea pig lung chronically treated with terbutaline. There was a significant decrease in the density of beta-adrenoceptors following chronic administration of terbutaline. Ketotifen prevented the decrease in beta-adrenoceptor density induced by terbutaline in a dose-dependent fashion; ketotifen alone, also increased the density of beta-adrenoceptors. However, neither ketotifen nor terbutaline significantly changed the KD values in either group. These findings suggest that ketotifen might be valuable when beta-agonists are administered for long term treatment in asthmatic patients.

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Ketotifen prevents terbutaline-induced down-regulation of beta-adrenoceptors in Guinea pig lung

Abstract

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