Abstract
Asthma is described as a chronic inflammatory disorder of the conducting airways. It is characterized by reversible airway obstruction, eosinophil and Th2 infiltration, airway hyper-responsiveness and airway remodeling. Our findings to date have largely been dependent on work done using animal models, which have been instrumental in broadening our understanding of the mechanism of the disease. However, using animals to model a uniquely human disease is not without its drawbacks. This review aims to examine some of the key mediators and cells of allergic asthma learned from animal models and shed some light on emerging mediators in the pathogenesis allergic airway inflammation in acute and chronic asthma.
| Original language | English |
|---|---|
| Pages (from-to) | 316-329 |
| Number of pages | 14 |
| Journal | International Immunopharmacology |
| Volume | 23 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2014 |
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All Science Journal Classification (ASJC) codes
- Immunology
- Immunology and Allergy
- Pharmacology
Cite this
Key mediators in the immunopathogenesis of allergic asthma. / Hall, Sannette; Agrawal, Devendra K.
In: International Immunopharmacology, Vol. 23, No. 1, 2014, p. 316-329.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Key mediators in the immunopathogenesis of allergic asthma
AU - Hall, Sannette
AU - Agrawal, Devendra K.
PY - 2014
Y1 - 2014
N2 - Asthma is described as a chronic inflammatory disorder of the conducting airways. It is characterized by reversible airway obstruction, eosinophil and Th2 infiltration, airway hyper-responsiveness and airway remodeling. Our findings to date have largely been dependent on work done using animal models, which have been instrumental in broadening our understanding of the mechanism of the disease. However, using animals to model a uniquely human disease is not without its drawbacks. This review aims to examine some of the key mediators and cells of allergic asthma learned from animal models and shed some light on emerging mediators in the pathogenesis allergic airway inflammation in acute and chronic asthma.
AB - Asthma is described as a chronic inflammatory disorder of the conducting airways. It is characterized by reversible airway obstruction, eosinophil and Th2 infiltration, airway hyper-responsiveness and airway remodeling. Our findings to date have largely been dependent on work done using animal models, which have been instrumental in broadening our understanding of the mechanism of the disease. However, using animals to model a uniquely human disease is not without its drawbacks. This review aims to examine some of the key mediators and cells of allergic asthma learned from animal models and shed some light on emerging mediators in the pathogenesis allergic airway inflammation in acute and chronic asthma.
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UR - http://www.scopus.com/inward/citedby.url?scp=84910663190&partnerID=8YFLogxK
U2 - 10.1016/j.intimp.2014.05.034
DO - 10.1016/j.intimp.2014.05.034
M3 - Article
VL - 23
SP - 316
EP - 329
JO - International Immunopharmacology
JF - International Immunopharmacology
SN - 1567-5769
IS - 1
ER -