Klinefelter Syndrome and Cancer

A Family Study

Henry T. Lynch, Arnold R. Kaplan, Jane F. Lynch

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The well-established relevance of familial and evidently genetic factors for breast cancer in women may be generalized to all individuals whose chromosome complements include two X chromosomes. Thus, an individual with a masculine phenotype, whose chromosome complement includes a Y chromosome as well as two X chromosomes may face the same risk as his sisters who lack a Y chromosome. The familial (genetic?) factor for cancer diathesis determines a relatively high risk for breast cancer in an individual with two X chromosomes. The familial factor for cancer diathesis is transmitted to and through individuals of both sexes. The usually sex-limited (ie, to females) manifestations of the relevant familial factor is evidently not directly related to gender but rather to interaction with an effect of the occurrence of two X chromosomes. Further medical genetic studies of Klinefelter patients and their families seem warranted in order to better appraise cancer epidemiology. (JAMA 229:809-811, 1974).

Original languageEnglish
Pages (from-to)809-811
Number of pages3
JournalJAMA - Journal of the American Medical Association
Volume229
Issue number7
DOIs
StatePublished - Aug 12 1974

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Klinefelter Syndrome
X Chromosome
Y Chromosome
Disease Susceptibility
Neoplasms
Chromosomes
Breast Neoplasms
Medical Genetics
Siblings
Epidemiology
Phenotype

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Klinefelter Syndrome and Cancer : A Family Study. / Lynch, Henry T.; Kaplan, Arnold R.; Lynch, Jane F.

In: JAMA - Journal of the American Medical Association, Vol. 229, No. 7, 12.08.1974, p. 809-811.

Research output: Contribution to journalArticle

Lynch, Henry T. ; Kaplan, Arnold R. ; Lynch, Jane F. / Klinefelter Syndrome and Cancer : A Family Study. In: JAMA - Journal of the American Medical Association. 1974 ; Vol. 229, No. 7. pp. 809-811.
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