Klinefelter Syndrome and Cancer: A Family Study

Henry T. Lynch, Arnold R. Kaplan, Jane F. Lynch

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


The well-established relevance of familial and evidently genetic factors for breast cancer in women may be generalized to all individuals whose chromosome complements include two X chromosomes. Thus, an individual with a masculine phenotype, whose chromosome complement includes a Y chromosome as well as two X chromosomes may face the same risk as his sisters who lack a Y chromosome. The familial (genetic?) factor for cancer diathesis determines a relatively high risk for breast cancer in an individual with two X chromosomes. The familial factor for cancer diathesis is transmitted to and through individuals of both sexes. The usually sex-limited (ie, to females) manifestations of the relevant familial factor is evidently not directly related to gender but rather to interaction with an effect of the occurrence of two X chromosomes. Further medical genetic studies of Klinefelter patients and their families seem warranted in order to better appraise cancer epidemiology. (JAMA 229:809-811, 1974).

Original languageEnglish (US)
Pages (from-to)809-811
Number of pages3
JournalJAMA: The Journal of the American Medical Association
Issue number7
StatePublished - Aug 12 1974

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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