Abstract
The well-established relevance of familial and evidently genetic factors for breast cancer in women may be generalized to all individuals whose chromosome complements include two X chromosomes. Thus, an individual with a masculine phenotype, whose chromosome complement includes a Y chromosome as well as two X chromosomes may face the same risk as his sisters who lack a Y chromosome. The familial (genetic?) factor for cancer diathesis determines a relatively high risk for breast cancer in an individual with two X chromosomes. The familial factor for cancer diathesis is transmitted to and through individuals of both sexes. The usually sex-limited (ie, to females) manifestations of the relevant familial factor is evidently not directly related to gender but rather to interaction with an effect of the occurrence of two X chromosomes. Further medical genetic studies of Klinefelter patients and their families seem warranted in order to better appraise cancer epidemiology. (JAMA 229:809-811, 1974).
| Original language | English |
|---|---|
| Pages (from-to) | 809-811 |
| Number of pages | 3 |
| Journal | JAMA - Journal of the American Medical Association |
| Volume | 229 |
| Issue number | 7 |
| DOIs | |
| State | Published - Aug 12 1974 |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
Cite this
Klinefelter Syndrome and Cancer : A Family Study. / Lynch, Henry T.; Kaplan, Arnold R.; Lynch, Jane F.
In: JAMA - Journal of the American Medical Association, Vol. 229, No. 7, 12.08.1974, p. 809-811.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Klinefelter Syndrome and Cancer
T2 - A Family Study
AU - Lynch, Henry T.
AU - Kaplan, Arnold R.
AU - Lynch, Jane F.
PY - 1974/8/12
Y1 - 1974/8/12
N2 - The well-established relevance of familial and evidently genetic factors for breast cancer in women may be generalized to all individuals whose chromosome complements include two X chromosomes. Thus, an individual with a masculine phenotype, whose chromosome complement includes a Y chromosome as well as two X chromosomes may face the same risk as his sisters who lack a Y chromosome. The familial (genetic?) factor for cancer diathesis determines a relatively high risk for breast cancer in an individual with two X chromosomes. The familial factor for cancer diathesis is transmitted to and through individuals of both sexes. The usually sex-limited (ie, to females) manifestations of the relevant familial factor is evidently not directly related to gender but rather to interaction with an effect of the occurrence of two X chromosomes. Further medical genetic studies of Klinefelter patients and their families seem warranted in order to better appraise cancer epidemiology. (JAMA 229:809-811, 1974).
AB - The well-established relevance of familial and evidently genetic factors for breast cancer in women may be generalized to all individuals whose chromosome complements include two X chromosomes. Thus, an individual with a masculine phenotype, whose chromosome complement includes a Y chromosome as well as two X chromosomes may face the same risk as his sisters who lack a Y chromosome. The familial (genetic?) factor for cancer diathesis determines a relatively high risk for breast cancer in an individual with two X chromosomes. The familial factor for cancer diathesis is transmitted to and through individuals of both sexes. The usually sex-limited (ie, to females) manifestations of the relevant familial factor is evidently not directly related to gender but rather to interaction with an effect of the occurrence of two X chromosomes. Further medical genetic studies of Klinefelter patients and their families seem warranted in order to better appraise cancer epidemiology. (JAMA 229:809-811, 1974).
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UR - http://www.scopus.com/inward/citedby.url?scp=0016291535&partnerID=8YFLogxK
U2 - 10.1001/jama.1974.03230450043024
DO - 10.1001/jama.1974.03230450043024
M3 - Article
VL - 229
SP - 809
EP - 811
JO - JAMA - Journal of the American Medical Association
JF - JAMA - Journal of the American Medical Association
SN - 0002-9955
IS - 7
ER -