Klinefelter's syndrome and metastatic breast cancer

D. M. Miller, H. T. Lynch

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


A case report is presented of a patient with Klinefelter's syndrome in whom breast cancer developed. The patient was in the direct genetic lineage of a cancer-prone family. Follow-up was maintained from the time his breast cancer was diagnosed until his death from metastases 12 years later. From our experience and from reports in literature, we recommend that patients with Klinefelter's syndrome be considered prime candidates for prophylactic total mastectomy, particularly in the presence of a family history of cancer. Intensive surveillance should be considered for those Klinefelter's patients who decline breast surgery.

Original languageEnglish (US)
Pages (from-to)23-24
Number of pages2
JournalBreast. Diseases of the Breast
Issue number3
StatePublished - Jan 1 1985
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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