Abstract
A laser-generated-focused ultrasound (LGFU) transducer generates high-pressure (up to 20 MPa), high-frequency (>10 MHz) shock waves with a tight focal spot. In this work, we aim to demonstrate the feasibility of using LGFU transducers for sonothrombolysis in vitro. A carbon black LGFU transducer was designed, fabricated and characterized. The prototyped LGFU was applied with in-vitro thrombolysis tests involving microbubble contrast agent (MCA). A conventional piezo ultrasound transducer was used as a secondary excitation source to enhance the cavitation effect by dual-frequency excitation. The in vitro test results showed that microbubble-mediated LGFU treatment can yield the lytic rate of approximately 2 mg/min, suggesting that LGFU transducers may be useful in precision high lytic rate sonothrombolysis.
Original language | English (US) |
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Title of host publication | 2016 IEEE International Ultrasonics Symposium, IUS 2016 |
Publisher | IEEE Computer Society |
Volume | 2016-November |
ISBN (Electronic) | 9781467398978 |
DOIs | |
State | Published - Nov 1 2016 |
Externally published | Yes |
Event | 2016 IEEE International Ultrasonics Symposium, IUS 2016 - Tours, France Duration: Sep 18 2016 → Sep 21 2016 |
Other
Other | 2016 IEEE International Ultrasonics Symposium, IUS 2016 |
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Country/Territory | France |
City | Tours |
Period | 9/18/16 → 9/21/16 |
All Science Journal Classification (ASJC) codes
- Acoustics and Ultrasonics