Laser-generated-focused ultrasound transducers for microbubble-mediated, dual-excitation sonothrombolysis

Jinwook Kim; Wei Yi Chang; Brooks D. Lindsey; Paul A. Dayton; Xuming Dai; Joseph Stavas; Xiaoning Jiang

doi:10.1109/ULTSYM.2016.7728473

Laser-generated-focused ultrasound transducers for microbubble-mediated, dual-excitation sonothrombolysis

Jinwook Kim, Wei Yi Chang, Brooks D. Lindsey, Paul A. Dayton, Xuming Dai, Joseph Stavas, Xiaoning Jiang

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

19 Scopus citations

Abstract

A laser-generated-focused ultrasound (LGFU) transducer generates high-pressure (up to 20 MPa), high-frequency (>10 MHz) shock waves with a tight focal spot. In this work, we aim to demonstrate the feasibility of using LGFU transducers for sonothrombolysis in vitro. A carbon black LGFU transducer was designed, fabricated and characterized. The prototyped LGFU was applied with in-vitro thrombolysis tests involving microbubble contrast agent (MCA). A conventional piezo ultrasound transducer was used as a secondary excitation source to enhance the cavitation effect by dual-frequency excitation. The in vitro test results showed that microbubble-mediated LGFU treatment can yield the lytic rate of approximately 2 mg/min, suggesting that LGFU transducers may be useful in precision high lytic rate sonothrombolysis.

Original language	English (US)
Title of host publication	2016 IEEE International Ultrasonics Symposium, IUS 2016
Publisher	IEEE Computer Society
Volume	2016-November
ISBN (Electronic)	9781467398978
DOIs	https://doi.org/10.1109/ULTSYM.2016.7728473
State	Published - Nov 1 2016
Externally published	Yes
Event	2016 IEEE International Ultrasonics Symposium, IUS 2016 - Tours, France Duration: Sep 18 2016 → Sep 21 2016

Other

Other	2016 IEEE International Ultrasonics Symposium, IUS 2016
Country/Territory	France
City	Tours
Period	9/18/16 → 9/21/16

All Science Journal Classification (ASJC) codes

Acoustics and Ultrasonics

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10.1109/ULTSYM.2016.7728473

Cite this

Kim, J, Chang, WY, Lindsey, BD, Dayton, PA, Dai, X, Stavas, J & Jiang, X 2016, Laser-generated-focused ultrasound transducers for microbubble-mediated, dual-excitation sonothrombolysis. in 2016 IEEE International Ultrasonics Symposium, IUS 2016. vol. 2016-November, 7728473, IEEE Computer Society, 2016 IEEE International Ultrasonics Symposium, IUS 2016, Tours, France, 9/18/16. https://doi.org/10.1109/ULTSYM.2016.7728473

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abstract = "A laser-generated-focused ultrasound (LGFU) transducer generates high-pressure (up to 20 MPa), high-frequency (>10 MHz) shock waves with a tight focal spot. In this work, we aim to demonstrate the feasibility of using LGFU transducers for sonothrombolysis in vitro. A carbon black LGFU transducer was designed, fabricated and characterized. The prototyped LGFU was applied with in-vitro thrombolysis tests involving microbubble contrast agent (MCA). A conventional piezo ultrasound transducer was used as a secondary excitation source to enhance the cavitation effect by dual-frequency excitation. The in vitro test results showed that microbubble-mediated LGFU treatment can yield the lytic rate of approximately 2 mg/min, suggesting that LGFU transducers may be useful in precision high lytic rate sonothrombolysis.",

author = "Jinwook Kim and Chang, {Wei Yi} and Lindsey, {Brooks D.} and Dayton, {Paul A.} and Xuming Dai and Joseph Stavas and Xiaoning Jiang",

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AU - Kim, Jinwook

AU - Chang, Wei Yi

AU - Lindsey, Brooks D.

AU - Dayton, Paul A.

AU - Dai, Xuming

AU - Stavas, Joseph

AU - Jiang, Xiaoning

PY - 2016/11/1

Y1 - 2016/11/1

N2 - A laser-generated-focused ultrasound (LGFU) transducer generates high-pressure (up to 20 MPa), high-frequency (>10 MHz) shock waves with a tight focal spot. In this work, we aim to demonstrate the feasibility of using LGFU transducers for sonothrombolysis in vitro. A carbon black LGFU transducer was designed, fabricated and characterized. The prototyped LGFU was applied with in-vitro thrombolysis tests involving microbubble contrast agent (MCA). A conventional piezo ultrasound transducer was used as a secondary excitation source to enhance the cavitation effect by dual-frequency excitation. The in vitro test results showed that microbubble-mediated LGFU treatment can yield the lytic rate of approximately 2 mg/min, suggesting that LGFU transducers may be useful in precision high lytic rate sonothrombolysis.

AB - A laser-generated-focused ultrasound (LGFU) transducer generates high-pressure (up to 20 MPa), high-frequency (>10 MHz) shock waves with a tight focal spot. In this work, we aim to demonstrate the feasibility of using LGFU transducers for sonothrombolysis in vitro. A carbon black LGFU transducer was designed, fabricated and characterized. The prototyped LGFU was applied with in-vitro thrombolysis tests involving microbubble contrast agent (MCA). A conventional piezo ultrasound transducer was used as a secondary excitation source to enhance the cavitation effect by dual-frequency excitation. The in vitro test results showed that microbubble-mediated LGFU treatment can yield the lytic rate of approximately 2 mg/min, suggesting that LGFU transducers may be useful in precision high lytic rate sonothrombolysis.

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M3 - Conference contribution

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VL - 2016-November

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PB - IEEE Computer Society

T2 - 2016 IEEE International Ultrasonics Symposium, IUS 2016

Y2 - 18 September 2016 through 21 September 2016

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Laser-generated-focused ultrasound transducers for microbubble-mediated, dual-excitation sonothrombolysis

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