Abstract
A laser-generated-focused ultrasound (LGFU) transducer generates high-pressure (up to 20 MPa), high-frequency (>10 MHz) shock waves with a tight focal spot. In this work, we aim to demonstrate the feasibility of using LGFU transducers for sonothrombolysis in vitro. A carbon black LGFU transducer was designed, fabricated and characterized. The prototyped LGFU was applied with in-vitro thrombolysis tests involving microbubble contrast agent (MCA). A conventional piezo ultrasound transducer was used as a secondary excitation source to enhance the cavitation effect by dual-frequency excitation. The in vitro test results showed that microbubble-mediated LGFU treatment can yield the lytic rate of approximately 2 mg/min, suggesting that LGFU transducers may be useful in precision high lytic rate sonothrombolysis.
| Original language | English (US) |
|---|---|
| Title of host publication | 2016 IEEE International Ultrasonics Symposium, IUS 2016 |
| Publisher | IEEE Computer Society |
| Volume | 2016-November |
| ISBN (Electronic) | 9781467398978 |
| DOIs | |
| State | Published - Nov 1 2016 |
| Externally published | Yes |
| Event | 2016 IEEE International Ultrasonics Symposium, IUS 2016 - Tours, France Duration: Sep 18 2016 → Sep 21 2016 |
Other
| Other | 2016 IEEE International Ultrasonics Symposium, IUS 2016 |
|---|---|
| Country | France |
| City | Tours |
| Period | 9/18/16 → 9/21/16 |
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All Science Journal Classification (ASJC) codes
- Acoustics and Ultrasonics
Cite this
Laser-generated-focused ultrasound transducers for microbubble-mediated, dual-excitation sonothrombolysis. / Kim, Jinwook; Chang, Wei Yi; Lindsey, Brooks D.; Dayton, Paul A.; Dai, Xuming; Stavas, Joseph; Jiang, Xiaoning.
2016 IEEE International Ultrasonics Symposium, IUS 2016. Vol. 2016-November IEEE Computer Society, 2016. 7728473.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Laser-generated-focused ultrasound transducers for microbubble-mediated, dual-excitation sonothrombolysis
AU - Kim, Jinwook
AU - Chang, Wei Yi
AU - Lindsey, Brooks D.
AU - Dayton, Paul A.
AU - Dai, Xuming
AU - Stavas, Joseph
AU - Jiang, Xiaoning
PY - 2016/11/1
Y1 - 2016/11/1
N2 - A laser-generated-focused ultrasound (LGFU) transducer generates high-pressure (up to 20 MPa), high-frequency (>10 MHz) shock waves with a tight focal spot. In this work, we aim to demonstrate the feasibility of using LGFU transducers for sonothrombolysis in vitro. A carbon black LGFU transducer was designed, fabricated and characterized. The prototyped LGFU was applied with in-vitro thrombolysis tests involving microbubble contrast agent (MCA). A conventional piezo ultrasound transducer was used as a secondary excitation source to enhance the cavitation effect by dual-frequency excitation. The in vitro test results showed that microbubble-mediated LGFU treatment can yield the lytic rate of approximately 2 mg/min, suggesting that LGFU transducers may be useful in precision high lytic rate sonothrombolysis.
AB - A laser-generated-focused ultrasound (LGFU) transducer generates high-pressure (up to 20 MPa), high-frequency (>10 MHz) shock waves with a tight focal spot. In this work, we aim to demonstrate the feasibility of using LGFU transducers for sonothrombolysis in vitro. A carbon black LGFU transducer was designed, fabricated and characterized. The prototyped LGFU was applied with in-vitro thrombolysis tests involving microbubble contrast agent (MCA). A conventional piezo ultrasound transducer was used as a secondary excitation source to enhance the cavitation effect by dual-frequency excitation. The in vitro test results showed that microbubble-mediated LGFU treatment can yield the lytic rate of approximately 2 mg/min, suggesting that LGFU transducers may be useful in precision high lytic rate sonothrombolysis.
UR - http://www.scopus.com/inward/record.url?scp=84996483734&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84996483734&partnerID=8YFLogxK
U2 - 10.1109/ULTSYM.2016.7728473
DO - 10.1109/ULTSYM.2016.7728473
M3 - Conference contribution
AN - SCOPUS:84996483734
VL - 2016-November
BT - 2016 IEEE International Ultrasonics Symposium, IUS 2016
PB - IEEE Computer Society
ER -