Laser-generated-focused ultrasound transducers for microbubble-mediated, dual-excitation sonothrombolysis

Jinwook Kim, Wei Yi Chang, Brooks D. Lindsey, Paul A. Dayton, Xuming Dai, Joseph Stavas, Xiaoning Jiang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Scopus citations

Abstract

A laser-generated-focused ultrasound (LGFU) transducer generates high-pressure (up to 20 MPa), high-frequency (>10 MHz) shock waves with a tight focal spot. In this work, we aim to demonstrate the feasibility of using LGFU transducers for sonothrombolysis in vitro. A carbon black LGFU transducer was designed, fabricated and characterized. The prototyped LGFU was applied with in-vitro thrombolysis tests involving microbubble contrast agent (MCA). A conventional piezo ultrasound transducer was used as a secondary excitation source to enhance the cavitation effect by dual-frequency excitation. The in vitro test results showed that microbubble-mediated LGFU treatment can yield the lytic rate of approximately 2 mg/min, suggesting that LGFU transducers may be useful in precision high lytic rate sonothrombolysis.

Original languageEnglish (US)
Title of host publication2016 IEEE International Ultrasonics Symposium, IUS 2016
PublisherIEEE Computer Society
Volume2016-November
ISBN (Electronic)9781467398978
DOIs
StatePublished - Nov 1 2016
Externally publishedYes
Event2016 IEEE International Ultrasonics Symposium, IUS 2016 - Tours, France
Duration: Sep 18 2016Sep 21 2016

Other

Other2016 IEEE International Ultrasonics Symposium, IUS 2016
CountryFrance
CityTours
Period9/18/169/21/16

All Science Journal Classification (ASJC) codes

  • Acoustics and Ultrasonics

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    Kim, J., Chang, W. Y., Lindsey, B. D., Dayton, P. A., Dai, X., Stavas, J., & Jiang, X. (2016). Laser-generated-focused ultrasound transducers for microbubble-mediated, dual-excitation sonothrombolysis. In 2016 IEEE International Ultrasonics Symposium, IUS 2016 (Vol. 2016-November). [7728473] IEEE Computer Society. https://doi.org/10.1109/ULTSYM.2016.7728473