Laser-generated-focused ultrasound transducers for microbubble-mediated, dual-excitation sonothrombolysis

Jinwook Kim, Wei Yi Chang, Brooks D. Lindsey, Paul A. Dayton, Xuming Dai, Joseph Stavas, Xiaoning Jiang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Citations (Scopus)

Abstract

A laser-generated-focused ultrasound (LGFU) transducer generates high-pressure (up to 20 MPa), high-frequency (>10 MHz) shock waves with a tight focal spot. In this work, we aim to demonstrate the feasibility of using LGFU transducers for sonothrombolysis in vitro. A carbon black LGFU transducer was designed, fabricated and characterized. The prototyped LGFU was applied with in-vitro thrombolysis tests involving microbubble contrast agent (MCA). A conventional piezo ultrasound transducer was used as a secondary excitation source to enhance the cavitation effect by dual-frequency excitation. The in vitro test results showed that microbubble-mediated LGFU treatment can yield the lytic rate of approximately 2 mg/min, suggesting that LGFU transducers may be useful in precision high lytic rate sonothrombolysis.

Original languageEnglish (US)
Title of host publication2016 IEEE International Ultrasonics Symposium, IUS 2016
PublisherIEEE Computer Society
Volume2016-November
ISBN (Electronic)9781467398978
DOIs
StatePublished - Nov 1 2016
Externally publishedYes
Event2016 IEEE International Ultrasonics Symposium, IUS 2016 - Tours, France
Duration: Sep 18 2016Sep 21 2016

Other

Other2016 IEEE International Ultrasonics Symposium, IUS 2016
CountryFrance
CityTours
Period9/18/169/21/16

Fingerprint

transducers
excitation
lasers
cavitation flow
shock waves
carbon

All Science Journal Classification (ASJC) codes

  • Acoustics and Ultrasonics

Cite this

Kim, J., Chang, W. Y., Lindsey, B. D., Dayton, P. A., Dai, X., Stavas, J., & Jiang, X. (2016). Laser-generated-focused ultrasound transducers for microbubble-mediated, dual-excitation sonothrombolysis. In 2016 IEEE International Ultrasonics Symposium, IUS 2016 (Vol. 2016-November). [7728473] IEEE Computer Society. https://doi.org/10.1109/ULTSYM.2016.7728473

Laser-generated-focused ultrasound transducers for microbubble-mediated, dual-excitation sonothrombolysis. / Kim, Jinwook; Chang, Wei Yi; Lindsey, Brooks D.; Dayton, Paul A.; Dai, Xuming; Stavas, Joseph; Jiang, Xiaoning.

2016 IEEE International Ultrasonics Symposium, IUS 2016. Vol. 2016-November IEEE Computer Society, 2016. 7728473.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Kim, J, Chang, WY, Lindsey, BD, Dayton, PA, Dai, X, Stavas, J & Jiang, X 2016, Laser-generated-focused ultrasound transducers for microbubble-mediated, dual-excitation sonothrombolysis. in 2016 IEEE International Ultrasonics Symposium, IUS 2016. vol. 2016-November, 7728473, IEEE Computer Society, 2016 IEEE International Ultrasonics Symposium, IUS 2016, Tours, France, 9/18/16. https://doi.org/10.1109/ULTSYM.2016.7728473
Kim J, Chang WY, Lindsey BD, Dayton PA, Dai X, Stavas J et al. Laser-generated-focused ultrasound transducers for microbubble-mediated, dual-excitation sonothrombolysis. In 2016 IEEE International Ultrasonics Symposium, IUS 2016. Vol. 2016-November. IEEE Computer Society. 2016. 7728473 https://doi.org/10.1109/ULTSYM.2016.7728473
Kim, Jinwook ; Chang, Wei Yi ; Lindsey, Brooks D. ; Dayton, Paul A. ; Dai, Xuming ; Stavas, Joseph ; Jiang, Xiaoning. / Laser-generated-focused ultrasound transducers for microbubble-mediated, dual-excitation sonothrombolysis. 2016 IEEE International Ultrasonics Symposium, IUS 2016. Vol. 2016-November IEEE Computer Society, 2016.
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