Abstract
To evaluate the efficacy of LDH isoenzymes in the detection of myocardial infarction in patients undergoing coronary bypass surgery, 73 patients were studied pre- and postoperatively by ECG, CPK, SGOT, total serum LDH, and LDH isoenzyme measurements. A reversal of the LDH1:LDH2 ratio was considered indicative of myocardial necrosis. Accordingly, the patients were separated into two groups: Group A (23 patients) who demonstrated an LDH1:LDH2 ratio exceeding 1.0 and Group B (50 patients) who failed to reveal and LDH1:LDH2 reversal. The two groups were similar in regard to preoperative evaluation and operative procedure performed. The postoperative ECG findings were significantly different. In Group A 18 of 23 patients (78 per cent) developed significant new Q waves. This occurred in only one patient in Group B. Significant arrhythmias occurred in 70 per cent of the patients in Group A as compared to 14 per cent of those patients in Group B. Severe congestive heart failure and/or clinical evidence of shock occurred in 39 per cent of Group A patients and in none in Group B. The results of our study indicate that the reversal of the LDH1:LDH2 ratio is a valuable tool for the evaluation of postoperative myocardial infarction.
| Original language | English |
|---|---|
| Pages (from-to) | 584-588 |
| Number of pages | 5 |
| Journal | American Heart Journal |
| Volume | 92 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1976 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine
Cite this
LDH isoenzymes and myocardial infarction in patients undergoing coronary bypass surgery : An excellent correlation. / Mohiuddin, Syed M.; Raffetto, Joseph; Sketch, Michael H.; Lynch, Joseph D.; Schultz, Richard D.; Runco, Vincent.
In: American Heart Journal, Vol. 92, No. 5, 1976, p. 584-588.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - LDH isoenzymes and myocardial infarction in patients undergoing coronary bypass surgery
T2 - An excellent correlation
AU - Mohiuddin, Syed M.
AU - Raffetto, Joseph
AU - Sketch, Michael H.
AU - Lynch, Joseph D.
AU - Schultz, Richard D.
AU - Runco, Vincent
PY - 1976
Y1 - 1976
N2 - To evaluate the efficacy of LDH isoenzymes in the detection of myocardial infarction in patients undergoing coronary bypass surgery, 73 patients were studied pre- and postoperatively by ECG, CPK, SGOT, total serum LDH, and LDH isoenzyme measurements. A reversal of the LDH1:LDH2 ratio was considered indicative of myocardial necrosis. Accordingly, the patients were separated into two groups: Group A (23 patients) who demonstrated an LDH1:LDH2 ratio exceeding 1.0 and Group B (50 patients) who failed to reveal and LDH1:LDH2 reversal. The two groups were similar in regard to preoperative evaluation and operative procedure performed. The postoperative ECG findings were significantly different. In Group A 18 of 23 patients (78 per cent) developed significant new Q waves. This occurred in only one patient in Group B. Significant arrhythmias occurred in 70 per cent of the patients in Group A as compared to 14 per cent of those patients in Group B. Severe congestive heart failure and/or clinical evidence of shock occurred in 39 per cent of Group A patients and in none in Group B. The results of our study indicate that the reversal of the LDH1:LDH2 ratio is a valuable tool for the evaluation of postoperative myocardial infarction.
AB - To evaluate the efficacy of LDH isoenzymes in the detection of myocardial infarction in patients undergoing coronary bypass surgery, 73 patients were studied pre- and postoperatively by ECG, CPK, SGOT, total serum LDH, and LDH isoenzyme measurements. A reversal of the LDH1:LDH2 ratio was considered indicative of myocardial necrosis. Accordingly, the patients were separated into two groups: Group A (23 patients) who demonstrated an LDH1:LDH2 ratio exceeding 1.0 and Group B (50 patients) who failed to reveal and LDH1:LDH2 reversal. The two groups were similar in regard to preoperative evaluation and operative procedure performed. The postoperative ECG findings were significantly different. In Group A 18 of 23 patients (78 per cent) developed significant new Q waves. This occurred in only one patient in Group B. Significant arrhythmias occurred in 70 per cent of the patients in Group A as compared to 14 per cent of those patients in Group B. Severe congestive heart failure and/or clinical evidence of shock occurred in 39 per cent of Group A patients and in none in Group B. The results of our study indicate that the reversal of the LDH1:LDH2 ratio is a valuable tool for the evaluation of postoperative myocardial infarction.
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UR - http://www.scopus.com/inward/citedby.url?scp=0017158804&partnerID=8YFLogxK
U2 - 10.1016/S0002-8703(76)80077-4
DO - 10.1016/S0002-8703(76)80077-4
M3 - Article
C2 - 1086587
AN - SCOPUS:0017158804
VL - 92
SP - 584
EP - 588
JO - American Heart Journal
JF - American Heart Journal
SN - 0002-8703
IS - 5
ER -