Levonantradol-induced inhibition of acetylcholine turnover in rat hippocampus and striatum.

E. Costa, D. L. Cheney, Thomas F. Murray

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The effects of levonantradol, a structural novel cannabinoid-related analgesic, on the turnover rate of acetylcholine (TRACh) have been studied in various regions of the rat brain. Levonantradol (0.3 mg/kg subcutaneously) decreases the tRACh in the hippocampus and striatum by 53 and 30 per cent, respectively. The extent of the reduction in TRACh is dose dependent, with a maximal decrease of 80 per cent in the hippocampus and 57 per cent in the striatum following the 3 mg/kg dose. In contrast, cortical TRACh is not affected by any dose of levonantradol. This pattern of activity on cholinergic dynamics elicited by levonantradol is qualitatively similar to that of cannabinoids but differs from that previously reported for narcotic analgesics. Moreover naltrexone (2 mg/kg intraperitoneally) does not reverse the effects of levonantradol on striatal or hippocampal TRACh. This pattern of activity on cholinergic dynamics elicited by levonantradol is consistent with a cannabinoid-like rather than an opioid-like mode of action.

Original languageEnglish
JournalJournal of Clinical Pharmacology
Volume21
Issue number8-9 Suppl
StatePublished - Aug 1981
Externally publishedYes

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Acetylcholine
Hippocampus
Cannabinoids
Cholinergic Agents
Corpus Striatum
Naltrexone
Narcotics
Opioid Analgesics
Analgesics
nantradol
Brain

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Levonantradol-induced inhibition of acetylcholine turnover in rat hippocampus and striatum. / Costa, E.; Cheney, D. L.; Murray, Thomas F.

In: Journal of Clinical Pharmacology, Vol. 21, No. 8-9 Suppl, 08.1981.

Research output: Contribution to journalArticle

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