Linkage and Association Between CA Repeat Polymorphism of the TNFR2 Gene and Obesity Phenotypes in Two Independent Caucasian Populations

Qing Yang HUANG, Hui SHEN, Hong Yi DENG, Theresa Conway, Elze Leo, K. Michael Davies, Robert R. Recker, Hong Wen DENG

Research output: Contribution to journalArticle

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Abstract

Previously, our group has reported a suggestive linkage evidence of 1p36 with body mass index (BMI) (LOD = 2.09). The tumor necrosis factor receptor 2 (TNFR2) at 1p36 is an excellent positional and functional candidate gene for obesity. In this study, we have investigated the linkage and association between the TNFR2 gene and obesity phenotypes in two large independent samples, using the quantitative transmission disequilibrium tests (QTDT). The first group was made up of 1 836 individuals from 79 multi-generation pedigrees. The second group was a randomly ascertained set of 636 individuals from 157 US Caucasian nuclear families. Obesity phenotypes tested include BMI, fat mass, and percentage fat mass (PFM). A significant result (P = 0.0056) was observed for linkage with BMI in the sample of the multigenerational pedigrees. Our data support the TNFR2 gene as a quantitative trait locus (QTL) underlying BMI variation in the Caucasian populations.

Original languageEnglish
Pages (from-to)775-781
Number of pages7
JournalActa Genetica Sinica
Volume33
Issue number9
DOIs
StatePublished - Sep 2006

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Receptors, Tumor Necrosis Factor, Type II
Body Mass Index
Obesity
Phenotype
Pedigree
Population
Genes
Fats
Quantitative Trait Loci
Nuclear Family

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Linkage and Association Between CA Repeat Polymorphism of the TNFR2 Gene and Obesity Phenotypes in Two Independent Caucasian Populations. / HUANG, Qing Yang; SHEN, Hui; DENG, Hong Yi; Conway, Theresa; Leo, Elze; Davies, K. Michael; Recker, Robert R.; DENG, Hong Wen.

In: Acta Genetica Sinica, Vol. 33, No. 9, 09.2006, p. 775-781.

Research output: Contribution to journalArticle

HUANG, Qing Yang ; SHEN, Hui ; DENG, Hong Yi ; Conway, Theresa ; Leo, Elze ; Davies, K. Michael ; Recker, Robert R. ; DENG, Hong Wen. / Linkage and Association Between CA Repeat Polymorphism of the TNFR2 Gene and Obesity Phenotypes in Two Independent Caucasian Populations. In: Acta Genetica Sinica. 2006 ; Vol. 33, No. 9. pp. 775-781.
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