Linkage and association of the CA repeat polymorphism of the IL6 gene, obesity-related phenotypes, and bone mineral density (BMD) in two independent Caucasian populations

Qing Yang Huang, Hui Shen, Hong Yi Deng, Theresa Conway, K. Michael Davies, Jin Long Li, Robert R. Recker, Hong Wen Deng

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Genetic factors play an important role in osteoporosis and obesity, two serious public health problems in the world. We investigated the relationships between obesity-related phenotypes, bone mineral density (BMD) and the CA repeat polymorphism of the IL6 gene in two large independent samples using the quantitative transmission disequilibrium test (QTDT). The first sample consisted of 1,816 individuals from 79 multigenerational pedigrees. Each pedigree was identified through a proband with BMD Z-scores ≤ -1.28 at the hip or spine. The second sample was a randomly ascertained set of 636 individuals from 157 nuclear families. Ten alleles containing 9-18 CA repeats were identified in our Caucasian populations. For body mass index (BMI), fat mass and percentage fat mass (PFM), highly significant (P

Original languageEnglish
Pages (from-to)430-437
Number of pages8
JournalJournal of Human Genetics
Volume48
Issue number8
DOIs
StatePublished - 2003

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Pedigree
Bone Density
Interleukin-6
Obesity
Fats
Phenotype
Nuclear Family
Population
Genes
Osteoporosis
Hip
Spine
Body Mass Index
Public Health
Alleles

All Science Journal Classification (ASJC) codes

  • Genetics(clinical)
  • Genetics

Cite this

Linkage and association of the CA repeat polymorphism of the IL6 gene, obesity-related phenotypes, and bone mineral density (BMD) in two independent Caucasian populations. / Huang, Qing Yang; Shen, Hui; Deng, Hong Yi; Conway, Theresa; Davies, K. Michael; Li, Jin Long; Recker, Robert R.; Deng, Hong Wen.

In: Journal of Human Genetics, Vol. 48, No. 8, 2003, p. 430-437.

Research output: Contribution to journalArticle

Huang, Qing Yang ; Shen, Hui ; Deng, Hong Yi ; Conway, Theresa ; Davies, K. Michael ; Li, Jin Long ; Recker, Robert R. ; Deng, Hong Wen. / Linkage and association of the CA repeat polymorphism of the IL6 gene, obesity-related phenotypes, and bone mineral density (BMD) in two independent Caucasian populations. In: Journal of Human Genetics. 2003 ; Vol. 48, No. 8. pp. 430-437.
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