Linkage exclusion analysis of two candidate regions on chromosomes 7 and 11

Leptin and UCP2/UCP3 are not QTLs for obesity in US Caucasians

Jing Jing Guo, Yong Jun Liu, Miao Xing Li, Yan Jun Yang, Robert R. Recker, Hong Wen Deng

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Leptin (LEP) and the uncoupling proteins 2 and 3 (UCP2/UCP3) are key molecules involved in the regulation of food intake and energy expenditure. However, their contribution to variation of obesity phenotypes in the general population remains controversial. The present study is to investigate whether chromosomal regions 7q and 11q, which contain LEP and UCP2/UCP3, respectively, can be excluded for linkage with obesity phenotypes. The obesity phenotypes include body mass index (BMI), fat mass, and percentage fat mass (PFM), with the latter two measured by dual-energy X-ray absorptiometry. We conducted exclusion linkage analyses using a variance component approach in a sample of 1816 individuals coming from 79 extended Caucasian pedigrees. In this study, we were able to exclude chromosomal region 7q containing LEP as having an effect on fat mass and PFM at effect sizes of 5% or greater, and on BMI at effect sizes of 10% or greater. We were able to exclude chromosomal region 11q containing UCP2/UCP3 as having an effect on fat mass and PFM at effect sizes of 10% or greater, and on BMI at effect sizes of 5% or greater. Our results suggest that the LEP and UCP2/UCP3 genes are unlikely to have a substantial effect on variation in obesity phenotypes in this particular US Caucasian population.

Original languageEnglish
Pages (from-to)602-608
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume332
Issue number2
DOIs
StatePublished - Jul 1 2005

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Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 7
Chromosomes
Leptin
Obesity
Fats
Phenotype
Body Mass Index
Appetite Regulation
Photon Absorptiometry
Pedigree
Energy Metabolism
Population
Genes
X rays
Molecules
Proteins

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Linkage exclusion analysis of two candidate regions on chromosomes 7 and 11 : Leptin and UCP2/UCP3 are not QTLs for obesity in US Caucasians. / Guo, Jing Jing; Liu, Yong Jun; Li, Miao Xing; Yang, Yan Jun; Recker, Robert R.; Deng, Hong Wen.

In: Biochemical and Biophysical Research Communications, Vol. 332, No. 2, 01.07.2005, p. 602-608.

Research output: Contribution to journalArticle

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abstract = "Leptin (LEP) and the uncoupling proteins 2 and 3 (UCP2/UCP3) are key molecules involved in the regulation of food intake and energy expenditure. However, their contribution to variation of obesity phenotypes in the general population remains controversial. The present study is to investigate whether chromosomal regions 7q and 11q, which contain LEP and UCP2/UCP3, respectively, can be excluded for linkage with obesity phenotypes. The obesity phenotypes include body mass index (BMI), fat mass, and percentage fat mass (PFM), with the latter two measured by dual-energy X-ray absorptiometry. We conducted exclusion linkage analyses using a variance component approach in a sample of 1816 individuals coming from 79 extended Caucasian pedigrees. In this study, we were able to exclude chromosomal region 7q containing LEP as having an effect on fat mass and PFM at effect sizes of 5{\%} or greater, and on BMI at effect sizes of 10{\%} or greater. We were able to exclude chromosomal region 11q containing UCP2/UCP3 as having an effect on fat mass and PFM at effect sizes of 10{\%} or greater, and on BMI at effect sizes of 5{\%} or greater. Our results suggest that the LEP and UCP2/UCP3 genes are unlikely to have a substantial effect on variation in obesity phenotypes in this particular US Caucasian population.",
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