Linkage exclusion mapping with bone size in 79 Caucasian pedigrees

Xiang Ding Chen, Hui Shen, Robert R. Recker, Hong Wen Deng

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Bone size is an important risk factor of osteoporotic fractures and has strong genetic determination. However, genetic studies on bone size variation are relatively rare. In the present study, we conducted a linkage exclusion mapping for bone size variation on chromosomes 1, 4, 6, and 17 in 79 Caucasian pedigrees. For hip bone size variation, several genomic regions were excluded at effect sizes of 10% or greater, including regions of 61-77cM at 1p35-p34, 43-59cM at 4p15-p13, 1-59cM at 6p25-p21, 82-88cM at 17q23-q24, and 113-114cM at 17q25. For spine bone size, at effect sizes of 10% or greater, we excluded regions of 115-122cM at 1p31-p22, 136-141cM at 1p21, 207-260cM at 1q31-q42, 20-89cM at 4p16-q21, 11-21cM at 6p24-p23, and 1-6cM at 17p13. These results suggested that a number of candidate genes located in the excluded regions, such as the growth hormone (GH) gene, tumor necrosis factor-alpha (TNF-α) gene, and bone morphogenetic protein-3 (BMP3) gene, are unlikely to have a substantial effect on bone size variation in this Caucasian population.

Original languageEnglish
Pages (from-to)337-343
Number of pages7
JournalJournal of Bone and Mineral Metabolism
Volume24
Issue number4
DOIs
StatePublished - Jul 2006

Fingerprint

Chromosome Mapping
Pedigree
Bone and Bones
Genes
Bone Morphogenetic Protein 3
Pelvic Bones
Chromosomes, Human, Pair 4
Osteoporotic Fractures
Chromosomes, Human, Pair 1
Growth Hormone
Spine
Tumor Necrosis Factor-alpha
Population

All Science Journal Classification (ASJC) codes

  • Endocrinology

Cite this

Linkage exclusion mapping with bone size in 79 Caucasian pedigrees. / Chen, Xiang Ding; Shen, Hui; Recker, Robert R.; Deng, Hong Wen.

In: Journal of Bone and Mineral Metabolism, Vol. 24, No. 4, 07.2006, p. 337-343.

Research output: Contribution to journalArticle

Chen, Xiang Ding ; Shen, Hui ; Recker, Robert R. ; Deng, Hong Wen. / Linkage exclusion mapping with bone size in 79 Caucasian pedigrees. In: Journal of Bone and Mineral Metabolism. 2006 ; Vol. 24, No. 4. pp. 337-343.
@article{b6d04ae348334b32a43412f6bd4368a3,
title = "Linkage exclusion mapping with bone size in 79 Caucasian pedigrees",
abstract = "Bone size is an important risk factor of osteoporotic fractures and has strong genetic determination. However, genetic studies on bone size variation are relatively rare. In the present study, we conducted a linkage exclusion mapping for bone size variation on chromosomes 1, 4, 6, and 17 in 79 Caucasian pedigrees. For hip bone size variation, several genomic regions were excluded at effect sizes of 10{\%} or greater, including regions of 61-77cM at 1p35-p34, 43-59cM at 4p15-p13, 1-59cM at 6p25-p21, 82-88cM at 17q23-q24, and 113-114cM at 17q25. For spine bone size, at effect sizes of 10{\%} or greater, we excluded regions of 115-122cM at 1p31-p22, 136-141cM at 1p21, 207-260cM at 1q31-q42, 20-89cM at 4p16-q21, 11-21cM at 6p24-p23, and 1-6cM at 17p13. These results suggested that a number of candidate genes located in the excluded regions, such as the growth hormone (GH) gene, tumor necrosis factor-alpha (TNF-α) gene, and bone morphogenetic protein-3 (BMP3) gene, are unlikely to have a substantial effect on bone size variation in this Caucasian population.",
author = "Chen, {Xiang Ding} and Hui Shen and Recker, {Robert R.} and Deng, {Hong Wen}",
year = "2006",
month = "7",
doi = "10.1007/s00774-006-0692-1",
language = "English",
volume = "24",
pages = "337--343",
journal = "Journal of Bone and Mineral Metabolism",
issn = "0914-8779",
publisher = "Springer Japan",
number = "4",

}

TY - JOUR

T1 - Linkage exclusion mapping with bone size in 79 Caucasian pedigrees

AU - Chen, Xiang Ding

AU - Shen, Hui

AU - Recker, Robert R.

AU - Deng, Hong Wen

PY - 2006/7

Y1 - 2006/7

N2 - Bone size is an important risk factor of osteoporotic fractures and has strong genetic determination. However, genetic studies on bone size variation are relatively rare. In the present study, we conducted a linkage exclusion mapping for bone size variation on chromosomes 1, 4, 6, and 17 in 79 Caucasian pedigrees. For hip bone size variation, several genomic regions were excluded at effect sizes of 10% or greater, including regions of 61-77cM at 1p35-p34, 43-59cM at 4p15-p13, 1-59cM at 6p25-p21, 82-88cM at 17q23-q24, and 113-114cM at 17q25. For spine bone size, at effect sizes of 10% or greater, we excluded regions of 115-122cM at 1p31-p22, 136-141cM at 1p21, 207-260cM at 1q31-q42, 20-89cM at 4p16-q21, 11-21cM at 6p24-p23, and 1-6cM at 17p13. These results suggested that a number of candidate genes located in the excluded regions, such as the growth hormone (GH) gene, tumor necrosis factor-alpha (TNF-α) gene, and bone morphogenetic protein-3 (BMP3) gene, are unlikely to have a substantial effect on bone size variation in this Caucasian population.

AB - Bone size is an important risk factor of osteoporotic fractures and has strong genetic determination. However, genetic studies on bone size variation are relatively rare. In the present study, we conducted a linkage exclusion mapping for bone size variation on chromosomes 1, 4, 6, and 17 in 79 Caucasian pedigrees. For hip bone size variation, several genomic regions were excluded at effect sizes of 10% or greater, including regions of 61-77cM at 1p35-p34, 43-59cM at 4p15-p13, 1-59cM at 6p25-p21, 82-88cM at 17q23-q24, and 113-114cM at 17q25. For spine bone size, at effect sizes of 10% or greater, we excluded regions of 115-122cM at 1p31-p22, 136-141cM at 1p21, 207-260cM at 1q31-q42, 20-89cM at 4p16-q21, 11-21cM at 6p24-p23, and 1-6cM at 17p13. These results suggested that a number of candidate genes located in the excluded regions, such as the growth hormone (GH) gene, tumor necrosis factor-alpha (TNF-α) gene, and bone morphogenetic protein-3 (BMP3) gene, are unlikely to have a substantial effect on bone size variation in this Caucasian population.

UR - http://www.scopus.com/inward/record.url?scp=33745605770&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745605770&partnerID=8YFLogxK

U2 - 10.1007/s00774-006-0692-1

DO - 10.1007/s00774-006-0692-1

M3 - Article

VL - 24

SP - 337

EP - 343

JO - Journal of Bone and Mineral Metabolism

JF - Journal of Bone and Mineral Metabolism

SN - 0914-8779

IS - 4

ER -