Lipid changes after hormone replacement therapy for menopause

W. T. Kable, John Christopher G. Gallagher, L. Nachtigall, D. Goldgar

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Three regimens of hormone replacement therapy were administered to 62 postmenopausal women for a period of 12 weeks and evaluated for their effect on blood lipids. Each group was given a continuous dose of 0.625 mg of conjugated estrogens combined with either a continuous dose of 2.5 mg of medroxyprogesterone acetate or 5.0 mg of medroxyprogesterone acetate, or a cyclic dose of 5.0 mg of medroxyprogesterone acetate on days 17-28 of the cycle. After treatment there was a significant decrease in the total cholesterol (P <.0007) and low density lipoprotein cholesterol (P <.0001) together with a significant increase in high density lipoprotein cholesterol (P <.0029). There was no significant difference in the response of the blood lipids to the three hormone groups. Therefore, preference would depend on the combination that caused the least bleeding or amenorrhea.

Original languageEnglish
Pages (from-to)512-518
Number of pages7
JournalThe Journal of reproductive medicine
Volume35
Issue number5
StatePublished - 1990

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Medroxyprogesterone Acetate
Hormone Replacement Therapy
Menopause
Lipids
Conjugated (USP) Estrogens
Amenorrhea
LDL Cholesterol
HDL Cholesterol
Cholesterol
Hormones
Hemorrhage
Therapeutics

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Lipid changes after hormone replacement therapy for menopause. / Kable, W. T.; Gallagher, John Christopher G.; Nachtigall, L.; Goldgar, D.

In: The Journal of reproductive medicine, Vol. 35, No. 5, 1990, p. 512-518.

Research output: Contribution to journalArticle

Kable, WT, Gallagher, JCG, Nachtigall, L & Goldgar, D 1990, 'Lipid changes after hormone replacement therapy for menopause', The Journal of reproductive medicine, vol. 35, no. 5, pp. 512-518.
Kable, W. T. ; Gallagher, John Christopher G. ; Nachtigall, L. ; Goldgar, D. / Lipid changes after hormone replacement therapy for menopause. In: The Journal of reproductive medicine. 1990 ; Vol. 35, No. 5. pp. 512-518.
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