Liposarcoma of the perineum

Bernard Gondos, Murray J. Casey

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A liposarcoma of the perineal body was diagnosed in a 38-year-old woman. She presented with a hard lump in the perineal region of 2 months duration. Light microscopic examination revealed a poorly differentiated malignant neoplasm of undetermined type. Electron microscopy indicated that the tumor cells contained large irregular nuclei, prominent nucleoli, abundant rough endoplasmic reticulum, and variable amounts of lipid material, consistent with a pleomorphic liposarcoma. She was treated with posterior exenteration, including resection of the internal reproductive organs, anus, and rectum, perineum and vulva, and posterolateral vagina, leaving the anterior vagina in place. Eight months later, a nodule noted in the vagina was widely excised and found to represent recurrent liposarcoma. She was started on adjuvant chemotherapy at that time. Subsequently, there has been no evidence of additional tumor in the brief follow-up period to date. Liposarcomas generally occur in regions with large connective tissue spaces such as the retroperitoneal area, shoulder, and lower extremities. In reviewing the literature, we found only one case report of liposarcoma of the vulva and no previous cases of liposarcoma of the perineum.

Original languageEnglish
Pages (from-to)133-140
Number of pages8
JournalGynecologic Oncology
Volume14
Issue number1
DOIs
StatePublished - 1982
Externally publishedYes

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Perineum
Liposarcoma
Vagina
Vulva
Neoplasms
Rough Endoplasmic Reticulum
Anal Canal
Adjuvant Chemotherapy
Rectum
Connective Tissue
Lower Extremity
Electron Microscopy
Lipids
Light

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology
  • Oncology

Cite this

Liposarcoma of the perineum. / Gondos, Bernard; Casey, Murray J.

In: Gynecologic Oncology, Vol. 14, No. 1, 1982, p. 133-140.

Research output: Contribution to journalArticle

Gondos, Bernard ; Casey, Murray J. / Liposarcoma of the perineum. In: Gynecologic Oncology. 1982 ; Vol. 14, No. 1. pp. 133-140.
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