TY - JOUR
T1 - Liposomes and transferosomes
T2 - A breakthrough in topical and transdermal delivery
AU - Sapkota, Rachana
AU - Dash, Alekha K.
N1 - Funding Information:
School of Pharmacy and Health Professions, Creighton University provided financial support to Rachana Sapkota. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.
Publisher Copyright:
© 2021 Future Medicine Ltd.. All rights reserved.
PY - 2021/2
Y1 - 2021/2
N2 - The topical and transdermal routes of drug administration are long known to the field of pharmaceutics. These routes have been explored for the delivery of a wide range of therapeutic agents over centuries. However, the anatomy of the skin and the physicochemical properties of molecules limit their transport via these routes. To overcome these challenges, a nano-phospholipid carrier called liposome was developed in the 1960s. Liposomal delivery of drugs was reported to be limited to the upper layers of skin. This led to the development of self-regulating and self-adaptable vesicles known as transfersomes. This review critically evaluates the barriers in delivery across the skin, recent advancements in liposomes, transfersomes and their impact in the pharmaceutical field.
AB - The topical and transdermal routes of drug administration are long known to the field of pharmaceutics. These routes have been explored for the delivery of a wide range of therapeutic agents over centuries. However, the anatomy of the skin and the physicochemical properties of molecules limit their transport via these routes. To overcome these challenges, a nano-phospholipid carrier called liposome was developed in the 1960s. Liposomal delivery of drugs was reported to be limited to the upper layers of skin. This led to the development of self-regulating and self-adaptable vesicles known as transfersomes. This review critically evaluates the barriers in delivery across the skin, recent advancements in liposomes, transfersomes and their impact in the pharmaceutical field.
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U2 - 10.4155/tde-2020-0122
DO - 10.4155/tde-2020-0122
M3 - Review article
C2 - 33583219
AN - SCOPUS:85101207617
VL - 12
SP - 145
EP - 158
JO - Therapeutic Delivery
JF - Therapeutic Delivery
SN - 2041-5990
IS - 2
ER -