Local induction of tumor necrosis factor as a molecular mechanism of mucosal damage by gonococci

Zell A. McGee, Christopher M. Clemens, Robert L. Jensen, John J. Klein, Lee R. Barley, Gary L. Gorby

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

Tumor necrosis factor (TNF) is an endogenously produced cytokine that plays a critical role in mediating septic shock and multi-organ failure, but previous studies of the role TNF in disease have not examined its role in mucosal disease processes. In an experimental model of acute gonococcal salpingitis, gonococcal infection of human fallopian tube mucosa resulted in increased mucosal production of TNF. Recombinant human TNF-α damaged fallopian tube mucosa in a dose-response manner and produced epithelial damage with the same ultrastructural features as those observed in gonococcal infection. Blocking production of TNF during gonococcal infection diminished the extent of damage to fallopian tube mucosa. In addition to mediating systemic disease, such as septic shock, TNF is also produced locally, and can play a critical role in mediating mucosal disease processes, such as acute gonococcal salpingitis.

Original languageEnglish (US)
Pages (from-to)333-341
Number of pages9
JournalMicrobial Pathogenesis
Volume12
Issue number5
DOIs
StatePublished - May 1992

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Infectious Diseases

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