Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13

Richard Wooster; Susan L. Neuhausen; Jonathan Mangion; Yvette Quirk; Deborah Ford; Nadine Collins; Kim Nguyen; Sheila Seal; Thao Tran; Diane Averill; Patty Fields; Gill Marshall; Steven Narod; Gilbert M. Lenoir; Henry Lynch; Jean Feunteun; Peter Devilee; Cees J. Cornelisse; Fred H. Menko; Peter A. Daly; Wilma Ormiston; Ross McManus; Carole Pye; Cathryn M. Lewis; Lisa A. Cannon-Albright; Julian Peto; Bruce A.J. Ponder; Mark H. Skolnick; Douglas F. Easton; David E. Goldgar; Michael R. Stratton

doi:10.1126/science.8091231

Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13

Richard Wooster, Susan L. Neuhausen, Jonathan Mangion, Yvette Quirk, Deborah Ford, Nadine Collins, Kim Nguyen, Sheila Seal, Thao Tran, Diane Averill, Patty Fields, Gill Marshall, Steven Narod, Gilbert M. Lenoir, Henry Lynch, Jean Feunteun, Peter Devilee, Cees J. Cornelisse, Fred H. Menko, Peter A. DalyWilma Ormiston, Ross McManus, Carole Pye, Cathryn M. Lewis, Lisa A. Cannon-Albright, Julian Peto, Bruce A.J. Ponder, Mark H. Skolnick, Douglas F. Easton, David E. Goldgar, Michael R. Stratton

Department of Preventive Medicine

Research output: Contribution to journal › Article › peer-review

1513 Scopus citations

Abstract

A small proportion of breast cancer, in particular those cases arising at a young age, is due to the inheritance of dominant susceptibility genes conferring a high risk of the disease. A genomic linkage search was performed with 15 high-risk breast cancer families that were unlinked to the BRCA1 locus on chromosome 17q21. This analysis localized a second breast cancer susceptibility locus, BRCA2, to a 6-centimorgan interval on chromosome 13q12-13. Preliminary evidence suggests that BRCA2 confers a high risk of breast cancer but, unlike BRCA1, does not confer a substantially elevated risk of ovarian cancer.

Original language	English (US)
Pages (from-to)	2088-2090
Number of pages	3
Journal	Science
Volume	265
Issue number	5181
DOIs	https://doi.org/10.1126/science.8091231
State	Published - Sep 30 1994

All Science Journal Classification (ASJC) codes

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Wooster, R., Neuhausen, S. L., Mangion, J., Quirk, Y., Ford, D., Collins, N., Nguyen, K., Seal, S., Tran, T., Averill, D., Fields, P., Marshall, G., Narod, S., Lenoir, G. M., Lynch, H., Feunteun, J., Devilee, P., Cornelisse, C. J., Menko, F. H., ... Stratton, M. R. (1994). Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13. Science, 265(5181), 2088-2090. https://doi.org/10.1126/science.8091231

Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13. / Wooster, Richard; Neuhausen, Susan L.; Mangion, Jonathan; Quirk, Yvette; Ford, Deborah; Collins, Nadine; Nguyen, Kim; Seal, Sheila; Tran, Thao; Averill, Diane; Fields, Patty; Marshall, Gill; Narod, Steven; Lenoir, Gilbert M.; Lynch, Henry; Feunteun, Jean; Devilee, Peter; Cornelisse, Cees J.; Menko, Fred H.; Daly, Peter A.; Ormiston, Wilma; McManus, Ross; Pye, Carole; Lewis, Cathryn M.; Cannon-Albright, Lisa A.; Peto, Julian; Ponder, Bruce A.J.; Skolnick, Mark H.; Easton, Douglas F.; Goldgar, David E.; Stratton, Michael R.

In: Science, Vol. 265, No. 5181, 30.09.1994, p. 2088-2090.

Research output: Contribution to journal › Article › peer-review

Wooster, R, Neuhausen, SL, Mangion, J, Quirk, Y, Ford, D, Collins, N, Nguyen, K, Seal, S, Tran, T, Averill, D, Fields, P, Marshall, G, Narod, S, Lenoir, GM, Lynch, H, Feunteun, J, Devilee, P, Cornelisse, CJ, Menko, FH, Daly, PA, Ormiston, W, McManus, R, Pye, C, Lewis, CM, Cannon-Albright, LA, Peto, J, Ponder, BAJ, Skolnick, MH, Easton, DF, Goldgar, DE & Stratton, MR 1994, 'Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13', Science, vol. 265, no. 5181, pp. 2088-2090. https://doi.org/10.1126/science.8091231

Wooster, Richard ; Neuhausen, Susan L. ; Mangion, Jonathan ; Quirk, Yvette ; Ford, Deborah ; Collins, Nadine ; Nguyen, Kim ; Seal, Sheila ; Tran, Thao ; Averill, Diane ; Fields, Patty ; Marshall, Gill ; Narod, Steven ; Lenoir, Gilbert M. ; Lynch, Henry ; Feunteun, Jean ; Devilee, Peter ; Cornelisse, Cees J. ; Menko, Fred H. ; Daly, Peter A. ; Ormiston, Wilma ; McManus, Ross ; Pye, Carole ; Lewis, Cathryn M. ; Cannon-Albright, Lisa A. ; Peto, Julian ; Ponder, Bruce A.J. ; Skolnick, Mark H. ; Easton, Douglas F. ; Goldgar, David E. ; Stratton, Michael R. / Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13. In: Science. 1994 ; Vol. 265, No. 5181. pp. 2088-2090.

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title = "Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13",

abstract = "A small proportion of breast cancer, in particular those cases arising at a young age, is due to the inheritance of dominant susceptibility genes conferring a high risk of the disease. A genomic linkage search was performed with 15 high-risk breast cancer families that were unlinked to the BRCA1 locus on chromosome 17q21. This analysis localized a second breast cancer susceptibility locus, BRCA2, to a 6-centimorgan interval on chromosome 13q12-13. Preliminary evidence suggests that BRCA2 confers a high risk of breast cancer but, unlike BRCA1, does not confer a substantially elevated risk of ovarian cancer.",

author = "Richard Wooster and Neuhausen, {Susan L.} and Jonathan Mangion and Yvette Quirk and Deborah Ford and Nadine Collins and Kim Nguyen and Sheila Seal and Thao Tran and Diane Averill and Patty Fields and Gill Marshall and Steven Narod and Lenoir, {Gilbert M.} and Henry Lynch and Jean Feunteun and Peter Devilee and Cornelisse, {Cees J.} and Menko, {Fred H.} and Daly, {Peter A.} and Wilma Ormiston and Ross McManus and Carole Pye and Lewis, {Cathryn M.} and Cannon-Albright, {Lisa A.} and Julian Peto and Ponder, {Bruce A.J.} and Skolnick, {Mark H.} and Easton, {Douglas F.} and Goldgar, {David E.} and Stratton, {Michael R.}",

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AU - Ford, Deborah

AU - Collins, Nadine

AU - Nguyen, Kim

AU - Seal, Sheila

AU - Tran, Thao

AU - Averill, Diane

AU - Fields, Patty

AU - Marshall, Gill

AU - Narod, Steven

AU - Lenoir, Gilbert M.

AU - Lynch, Henry

AU - Feunteun, Jean

AU - Devilee, Peter

AU - Cornelisse, Cees J.

AU - Menko, Fred H.

AU - Daly, Peter A.

AU - Ormiston, Wilma

AU - McManus, Ross

AU - Pye, Carole

AU - Lewis, Cathryn M.

AU - Cannon-Albright, Lisa A.

AU - Peto, Julian

AU - Ponder, Bruce A.J.

AU - Skolnick, Mark H.

AU - Easton, Douglas F.

AU - Goldgar, David E.

AU - Stratton, Michael R.

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N2 - A small proportion of breast cancer, in particular those cases arising at a young age, is due to the inheritance of dominant susceptibility genes conferring a high risk of the disease. A genomic linkage search was performed with 15 high-risk breast cancer families that were unlinked to the BRCA1 locus on chromosome 17q21. This analysis localized a second breast cancer susceptibility locus, BRCA2, to a 6-centimorgan interval on chromosome 13q12-13. Preliminary evidence suggests that BRCA2 confers a high risk of breast cancer but, unlike BRCA1, does not confer a substantially elevated risk of ovarian cancer.

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Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13

Abstract

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