Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13

Richard Wooster; Susan L. Neuhausen; Jonathan Mangion; Yvette Quirk; Deborah Ford; Nadine Collins; Kim Nguyen; Sheila Seal; Thao Tran; Diane Averill; Patty Fields; Gill Marshall; Steven Narod; Gilbert M. Lenoir; Henry T. Lynch; Jean Feunteun; Peter Devilee; Cees J. Cornelisse; Fred H. Menko; Peter A. Daly; Wilma Ormiston; Ross McManus; Carole Pye; Cathryn M. Lewis; Lisa A. Cannon-Albright; Julian Peto; Bruce A J Ponder; Mark H. Skolnick; Douglas F. Easton; David E. Goldgar; Michael R. Stratton

Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13

Richard Wooster, Susan L. Neuhausen, Jonathan Mangion, Yvette Quirk, Deborah Ford, Nadine Collins, Kim Nguyen, Sheila Seal, Thao Tran, Diane Averill, Patty Fields, Gill Marshall, Steven Narod, Gilbert M. Lenoir, Henry T. Lynch, Jean Feunteun, Peter Devilee, Cees J. Cornelisse, Fred H. Menko, Peter A. DalyWilma Ormiston, Ross McManus, Carole Pye, Cathryn M. Lewis, Lisa A. Cannon-Albright, Julian Peto, Bruce A J Ponder, Mark H. Skolnick, Douglas F. Easton, David E. Goldgar, Michael R. Stratton

Department of Preventive Medicine

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1477 Scopus citations

Abstract

A small proportion of breast cancer, in particular those cases arising at a young age, is due to the inheritance of dominant susceptibility genes conferring a high risk of the disease. A genomic linkage search was performed with 15 high-risk breast cancer families that were unlinked to the BRCA1 locus on chromosome 17q21. This analysis localized a second breast cancer susceptibility locus, BRCA2, to a 6-centimorgan interval on chromosome 13q12-13. Preliminary evidence suggests that BRCA2 confers a high risk of breast cancer but, unlike BRCA1, does not confer a substantially elevated risk of ovarian cancer.

Original language	English
Pages (from-to)	2088-2090
Number of pages	3
Journal	Science
Volume	265
Issue number	5181
State	Published - Sep 30 1994

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Wooster, R., Neuhausen, S. L., Mangion, J., Quirk, Y., Ford, D., Collins, N., Nguyen, K., Seal, S., Tran, T., Averill, D., Fields, P., Marshall, G., Narod, S., Lenoir, G. M., Lynch, H. T., Feunteun, J., Devilee, P., Cornelisse, C. J., Menko, F. H., ... Stratton, M. R. (1994). Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13. Science, 265(5181), 2088-2090.

Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13. / Wooster, Richard; Neuhausen, Susan L.; Mangion, Jonathan; Quirk, Yvette; Ford, Deborah; Collins, Nadine; Nguyen, Kim; Seal, Sheila; Tran, Thao; Averill, Diane; Fields, Patty; Marshall, Gill; Narod, Steven; Lenoir, Gilbert M.; Lynch, Henry T.; Feunteun, Jean; Devilee, Peter; Cornelisse, Cees J.; Menko, Fred H.; Daly, Peter A.; Ormiston, Wilma; McManus, Ross; Pye, Carole; Lewis, Cathryn M.; Cannon-Albright, Lisa A.; Peto, Julian; Ponder, Bruce A J; Skolnick, Mark H.; Easton, Douglas F.; Goldgar, David E.; Stratton, Michael R.

In: Science, Vol. 265, No. 5181, 30.09.1994, p. 2088-2090.

Research output: Contribution to journal › Article

Wooster, R, Neuhausen, SL, Mangion, J, Quirk, Y, Ford, D, Collins, N, Nguyen, K, Seal, S, Tran, T, Averill, D, Fields, P, Marshall, G, Narod, S, Lenoir, GM, Lynch, HT, Feunteun, J, Devilee, P, Cornelisse, CJ, Menko, FH, Daly, PA, Ormiston, W, McManus, R, Pye, C, Lewis, CM, Cannon-Albright, LA, Peto, J, Ponder, BAJ, Skolnick, MH, Easton, DF, Goldgar, DE & Stratton, MR 1994, 'Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13', Science, vol. 265, no. 5181, pp. 2088-2090.

Wooster, Richard ; Neuhausen, Susan L. ; Mangion, Jonathan ; Quirk, Yvette ; Ford, Deborah ; Collins, Nadine ; Nguyen, Kim ; Seal, Sheila ; Tran, Thao ; Averill, Diane ; Fields, Patty ; Marshall, Gill ; Narod, Steven ; Lenoir, Gilbert M. ; Lynch, Henry T. ; Feunteun, Jean ; Devilee, Peter ; Cornelisse, Cees J. ; Menko, Fred H. ; Daly, Peter A. ; Ormiston, Wilma ; McManus, Ross ; Pye, Carole ; Lewis, Cathryn M. ; Cannon-Albright, Lisa A. ; Peto, Julian ; Ponder, Bruce A J ; Skolnick, Mark H. ; Easton, Douglas F. ; Goldgar, David E. ; Stratton, Michael R. / Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13. In: Science. 1994 ; Vol. 265, No. 5181. pp. 2088-2090.

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abstract = "A small proportion of breast cancer, in particular those cases arising at a young age, is due to the inheritance of dominant susceptibility genes conferring a high risk of the disease. A genomic linkage search was performed with 15 high-risk breast cancer families that were unlinked to the BRCA1 locus on chromosome 17q21. This analysis localized a second breast cancer susceptibility locus, BRCA2, to a 6-centimorgan interval on chromosome 13q12-13. Preliminary evidence suggests that BRCA2 confers a high risk of breast cancer but, unlike BRCA1, does not confer a substantially elevated risk of ovarian cancer.",

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AU - Wooster, Richard

AU - Neuhausen, Susan L.

AU - Mangion, Jonathan

AU - Quirk, Yvette

AU - Ford, Deborah

AU - Collins, Nadine

AU - Nguyen, Kim

AU - Seal, Sheila

AU - Tran, Thao

AU - Averill, Diane

AU - Fields, Patty

AU - Marshall, Gill

AU - Narod, Steven

AU - Lenoir, Gilbert M.

AU - Lynch, Henry T.

AU - Feunteun, Jean

AU - Devilee, Peter

AU - Cornelisse, Cees J.

AU - Menko, Fred H.

AU - Daly, Peter A.

AU - Ormiston, Wilma

AU - McManus, Ross

AU - Pye, Carole

AU - Lewis, Cathryn M.

AU - Cannon-Albright, Lisa A.

AU - Peto, Julian

AU - Ponder, Bruce A J

AU - Skolnick, Mark H.

AU - Easton, Douglas F.

AU - Goldgar, David E.

AU - Stratton, Michael R.

PY - 1994/9/30

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N2 - A small proportion of breast cancer, in particular those cases arising at a young age, is due to the inheritance of dominant susceptibility genes conferring a high risk of the disease. A genomic linkage search was performed with 15 high-risk breast cancer families that were unlinked to the BRCA1 locus on chromosome 17q21. This analysis localized a second breast cancer susceptibility locus, BRCA2, to a 6-centimorgan interval on chromosome 13q12-13. Preliminary evidence suggests that BRCA2 confers a high risk of breast cancer but, unlike BRCA1, does not confer a substantially elevated risk of ovarian cancer.

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SN - 0036-8075

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ER -

Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13

Abstract

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