Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13

Richard Wooster, Susan L. Neuhausen, Jonathan Mangion, Yvette Quirk, Deborah Ford, Nadine Collins, Kim Nguyen, Sheila Seal, Thao Tran, Diane Averill, Patty Fields, Gill Marshall, Steven Narod, Gilbert M. Lenoir, Henry T. Lynch, Jean Feunteun, Peter Devilee, Cees J. Cornelisse, Fred H. Menko, Peter A. Daly & 11 others Wilma Ormiston, Ross McManus, Carole Pye, Cathryn M. Lewis, Lisa A. Cannon-Albright, Julian Peto, Bruce A J Ponder, Mark H. Skolnick, Douglas F. Easton, David E. Goldgar, Michael R. Stratton

Research output: Contribution to journalArticle

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Abstract

A small proportion of breast cancer, in particular those cases arising at a young age, is due to the inheritance of dominant susceptibility genes conferring a high risk of the disease. A genomic linkage search was performed with 15 high-risk breast cancer families that were unlinked to the BRCA1 locus on chromosome 17q21. This analysis localized a second breast cancer susceptibility locus, BRCA2, to a 6-centimorgan interval on chromosome 13q12-13. Preliminary evidence suggests that BRCA2 confers a high risk of breast cancer but, unlike BRCA1, does not confer a substantially elevated risk of ovarian cancer.

Original languageEnglish
Pages (from-to)2088-2090
Number of pages3
JournalScience
Volume265
Issue number5181
StatePublished - Sep 30 1994

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Chromosomes, Human, Pair 13
Neoplasm Genes
Breast Neoplasms
Dominant Genes
Second Primary Neoplasms
Ovarian Neoplasms
Chromosomes

All Science Journal Classification (ASJC) codes

  • General

Cite this

Wooster, R., Neuhausen, S. L., Mangion, J., Quirk, Y., Ford, D., Collins, N., ... Stratton, M. R. (1994). Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13. Science, 265(5181), 2088-2090.

Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13. / Wooster, Richard; Neuhausen, Susan L.; Mangion, Jonathan; Quirk, Yvette; Ford, Deborah; Collins, Nadine; Nguyen, Kim; Seal, Sheila; Tran, Thao; Averill, Diane; Fields, Patty; Marshall, Gill; Narod, Steven; Lenoir, Gilbert M.; Lynch, Henry T.; Feunteun, Jean; Devilee, Peter; Cornelisse, Cees J.; Menko, Fred H.; Daly, Peter A.; Ormiston, Wilma; McManus, Ross; Pye, Carole; Lewis, Cathryn M.; Cannon-Albright, Lisa A.; Peto, Julian; Ponder, Bruce A J; Skolnick, Mark H.; Easton, Douglas F.; Goldgar, David E.; Stratton, Michael R.

In: Science, Vol. 265, No. 5181, 30.09.1994, p. 2088-2090.

Research output: Contribution to journalArticle

Wooster, R, Neuhausen, SL, Mangion, J, Quirk, Y, Ford, D, Collins, N, Nguyen, K, Seal, S, Tran, T, Averill, D, Fields, P, Marshall, G, Narod, S, Lenoir, GM, Lynch, HT, Feunteun, J, Devilee, P, Cornelisse, CJ, Menko, FH, Daly, PA, Ormiston, W, McManus, R, Pye, C, Lewis, CM, Cannon-Albright, LA, Peto, J, Ponder, BAJ, Skolnick, MH, Easton, DF, Goldgar, DE & Stratton, MR 1994, 'Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13', Science, vol. 265, no. 5181, pp. 2088-2090.
Wooster R, Neuhausen SL, Mangion J, Quirk Y, Ford D, Collins N et al. Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13. Science. 1994 Sep 30;265(5181):2088-2090.
Wooster, Richard ; Neuhausen, Susan L. ; Mangion, Jonathan ; Quirk, Yvette ; Ford, Deborah ; Collins, Nadine ; Nguyen, Kim ; Seal, Sheila ; Tran, Thao ; Averill, Diane ; Fields, Patty ; Marshall, Gill ; Narod, Steven ; Lenoir, Gilbert M. ; Lynch, Henry T. ; Feunteun, Jean ; Devilee, Peter ; Cornelisse, Cees J. ; Menko, Fred H. ; Daly, Peter A. ; Ormiston, Wilma ; McManus, Ross ; Pye, Carole ; Lewis, Cathryn M. ; Cannon-Albright, Lisa A. ; Peto, Julian ; Ponder, Bruce A J ; Skolnick, Mark H. ; Easton, Douglas F. ; Goldgar, David E. ; Stratton, Michael R. / Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13. In: Science. 1994 ; Vol. 265, No. 5181. pp. 2088-2090.
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AU - Neuhausen, Susan L.

AU - Mangion, Jonathan

AU - Quirk, Yvette

AU - Ford, Deborah

AU - Collins, Nadine

AU - Nguyen, Kim

AU - Seal, Sheila

AU - Tran, Thao

AU - Averill, Diane

AU - Fields, Patty

AU - Marshall, Gill

AU - Narod, Steven

AU - Lenoir, Gilbert M.

AU - Lynch, Henry T.

AU - Feunteun, Jean

AU - Devilee, Peter

AU - Cornelisse, Cees J.

AU - Menko, Fred H.

AU - Daly, Peter A.

AU - Ormiston, Wilma

AU - McManus, Ross

AU - Pye, Carole

AU - Lewis, Cathryn M.

AU - Cannon-Albright, Lisa A.

AU - Peto, Julian

AU - Ponder, Bruce A J

AU - Skolnick, Mark H.

AU - Easton, Douglas F.

AU - Goldgar, David E.

AU - Stratton, Michael R.

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