Abstract
A small proportion of breast cancer, in particular those cases arising at a young age, is due to the inheritance of dominant susceptibility genes conferring a high risk of the disease. A genomic linkage search was performed with 15 high-risk breast cancer families that were unlinked to the BRCA1 locus on chromosome 17q21. This analysis localized a second breast cancer susceptibility locus, BRCA2, to a 6-centimorgan interval on chromosome 13q12-13. Preliminary evidence suggests that BRCA2 confers a high risk of breast cancer but, unlike BRCA1, does not confer a substantially elevated risk of ovarian cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 2088-2090 |
| Number of pages | 3 |
| Journal | Science |
| Volume | 265 |
| Issue number | 5181 |
| State | Published - Sep 30 1994 |
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All Science Journal Classification (ASJC) codes
- General
Cite this
Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13. / Wooster, Richard; Neuhausen, Susan L.; Mangion, Jonathan; Quirk, Yvette; Ford, Deborah; Collins, Nadine; Nguyen, Kim; Seal, Sheila; Tran, Thao; Averill, Diane; Fields, Patty; Marshall, Gill; Narod, Steven; Lenoir, Gilbert M.; Lynch, Henry T.; Feunteun, Jean; Devilee, Peter; Cornelisse, Cees J.; Menko, Fred H.; Daly, Peter A.; Ormiston, Wilma; McManus, Ross; Pye, Carole; Lewis, Cathryn M.; Cannon-Albright, Lisa A.; Peto, Julian; Ponder, Bruce A J; Skolnick, Mark H.; Easton, Douglas F.; Goldgar, David E.; Stratton, Michael R.
In: Science, Vol. 265, No. 5181, 30.09.1994, p. 2088-2090.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13
AU - Wooster, Richard
AU - Neuhausen, Susan L.
AU - Mangion, Jonathan
AU - Quirk, Yvette
AU - Ford, Deborah
AU - Collins, Nadine
AU - Nguyen, Kim
AU - Seal, Sheila
AU - Tran, Thao
AU - Averill, Diane
AU - Fields, Patty
AU - Marshall, Gill
AU - Narod, Steven
AU - Lenoir, Gilbert M.
AU - Lynch, Henry T.
AU - Feunteun, Jean
AU - Devilee, Peter
AU - Cornelisse, Cees J.
AU - Menko, Fred H.
AU - Daly, Peter A.
AU - Ormiston, Wilma
AU - McManus, Ross
AU - Pye, Carole
AU - Lewis, Cathryn M.
AU - Cannon-Albright, Lisa A.
AU - Peto, Julian
AU - Ponder, Bruce A J
AU - Skolnick, Mark H.
AU - Easton, Douglas F.
AU - Goldgar, David E.
AU - Stratton, Michael R.
PY - 1994/9/30
Y1 - 1994/9/30
N2 - A small proportion of breast cancer, in particular those cases arising at a young age, is due to the inheritance of dominant susceptibility genes conferring a high risk of the disease. A genomic linkage search was performed with 15 high-risk breast cancer families that were unlinked to the BRCA1 locus on chromosome 17q21. This analysis localized a second breast cancer susceptibility locus, BRCA2, to a 6-centimorgan interval on chromosome 13q12-13. Preliminary evidence suggests that BRCA2 confers a high risk of breast cancer but, unlike BRCA1, does not confer a substantially elevated risk of ovarian cancer.
AB - A small proportion of breast cancer, in particular those cases arising at a young age, is due to the inheritance of dominant susceptibility genes conferring a high risk of the disease. A genomic linkage search was performed with 15 high-risk breast cancer families that were unlinked to the BRCA1 locus on chromosome 17q21. This analysis localized a second breast cancer susceptibility locus, BRCA2, to a 6-centimorgan interval on chromosome 13q12-13. Preliminary evidence suggests that BRCA2 confers a high risk of breast cancer but, unlike BRCA1, does not confer a substantially elevated risk of ovarian cancer.
UR - http://www.scopus.com/inward/record.url?scp=0028006563&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028006563&partnerID=8YFLogxK
M3 - Article
C2 - 8091231
AN - SCOPUS:0028006563
VL - 265
SP - 2088
EP - 2090
JO - Science
JF - Science
SN - 0036-8075
IS - 5181
ER -