Long non-coding RNAs (lncRNAs) and their transcriptional control of inflammatory responses

Nicholas W. Mathy, Xian-Ming Chen

Research output: Contribution to journalShort survey

18 Citations (Scopus)

Abstract

Long non-coding RNAs (lncRNAs) have emerged as potential key regulators of the inflammatory response, particularly by modulating the transcriptional control of inflammatory genes. lncRNAs may act as an enhancer or suppressor to inflammatory transcription, function as scaffold molecules through interactions with RNA-binding proteins in chromatin remodeling complexes, and modulate dynamic and epigenetic control of inflammatory transcription in a gene-specific and time-dependent fashion. Here, we will review recent literature regarding the role of lncRNAs in transcriptional control of inflammatory responses. Better understanding of lncRNA regulation of inflammation will provide novel targets for the development of new therapeutic strategies.

Original languageEnglish (US)
Pages (from-to)12375-12382
Number of pages8
JournalJournal of Biological Chemistry
Volume292
Issue number30
DOIs
StatePublished - 2017

Fingerprint

Long Noncoding RNA
Transcription
Genes
Chromatin Assembly and Disassembly
RNA-Binding Proteins
Epigenomics
Scaffolds
Chromatin
Inflammation
Molecules

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Long non-coding RNAs (lncRNAs) and their transcriptional control of inflammatory responses. / Mathy, Nicholas W.; Chen, Xian-Ming.

In: Journal of Biological Chemistry, Vol. 292, No. 30, 2017, p. 12375-12382.

Research output: Contribution to journalShort survey

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