Abstract
Background. The effects of chronic diuretic use on serum homocysteine and its metabolic cofactors vitamin B6, vitamin B12, and red blood cell (RBC) folate have not been well studied. Methods. Blood samples from 17 hypertensive patients receiving long-term diuretic therapy and 17 hypertensive patients not taking diuretics were analyzed for serum homocysteine, vitamin B6, vitamin B12, and RBC folate. Results. The mean serum homocysteine concentration for patients taking diuretics (17.87 ± 1.72 μmol/L) was significantly higher than the mean serum homocysteine concentration for patients not taking diuretics (10.31 ± 0.99 μmol/L). The mean RBC folate concentration for patients taking diuretics (281.01 ± 17.56 ng/mL) was significantly lower than the mean RBC folate concentration for patients not taking diuretics (430.85 ± 28.58 ng/mL). Serum vitamin B6 and vitamin B12 concentrations were not significantly different between the two groups. Conclusions. Chronic diuretic use is associated with a significant increase in serum homocysteine concentration, a significant decrease in RBC folate concentration, and no significant change in concentrations of vitamins B6 and B12.
| Original language | English |
|---|---|
| Pages (from-to) | 866-870 |
| Number of pages | 5 |
| Journal | Southern Medical Journal |
| Volume | 92 |
| Issue number | 9 |
| State | Published - Sep 1999 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
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Long-term diuretic therapy in hypertensive patients : Effects on serum homocysteine, vitamin B6, vitamin B12, and red blood cell folate concentrations. / Morrow, Lee E.; Grimsley, Edwin W.
In: Southern Medical Journal, Vol. 92, No. 9, 09.1999, p. 866-870.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Long-term diuretic therapy in hypertensive patients
T2 - Effects on serum homocysteine, vitamin B6, vitamin B12, and red blood cell folate concentrations
AU - Morrow, Lee E.
AU - Grimsley, Edwin W.
PY - 1999/9
Y1 - 1999/9
N2 - Background. The effects of chronic diuretic use on serum homocysteine and its metabolic cofactors vitamin B6, vitamin B12, and red blood cell (RBC) folate have not been well studied. Methods. Blood samples from 17 hypertensive patients receiving long-term diuretic therapy and 17 hypertensive patients not taking diuretics were analyzed for serum homocysteine, vitamin B6, vitamin B12, and RBC folate. Results. The mean serum homocysteine concentration for patients taking diuretics (17.87 ± 1.72 μmol/L) was significantly higher than the mean serum homocysteine concentration for patients not taking diuretics (10.31 ± 0.99 μmol/L). The mean RBC folate concentration for patients taking diuretics (281.01 ± 17.56 ng/mL) was significantly lower than the mean RBC folate concentration for patients not taking diuretics (430.85 ± 28.58 ng/mL). Serum vitamin B6 and vitamin B12 concentrations were not significantly different between the two groups. Conclusions. Chronic diuretic use is associated with a significant increase in serum homocysteine concentration, a significant decrease in RBC folate concentration, and no significant change in concentrations of vitamins B6 and B12.
AB - Background. The effects of chronic diuretic use on serum homocysteine and its metabolic cofactors vitamin B6, vitamin B12, and red blood cell (RBC) folate have not been well studied. Methods. Blood samples from 17 hypertensive patients receiving long-term diuretic therapy and 17 hypertensive patients not taking diuretics were analyzed for serum homocysteine, vitamin B6, vitamin B12, and RBC folate. Results. The mean serum homocysteine concentration for patients taking diuretics (17.87 ± 1.72 μmol/L) was significantly higher than the mean serum homocysteine concentration for patients not taking diuretics (10.31 ± 0.99 μmol/L). The mean RBC folate concentration for patients taking diuretics (281.01 ± 17.56 ng/mL) was significantly lower than the mean RBC folate concentration for patients not taking diuretics (430.85 ± 28.58 ng/mL). Serum vitamin B6 and vitamin B12 concentrations were not significantly different between the two groups. Conclusions. Chronic diuretic use is associated with a significant increase in serum homocysteine concentration, a significant decrease in RBC folate concentration, and no significant change in concentrations of vitamins B6 and B12.
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UR - http://www.scopus.com/inward/citedby.url?scp=0032879269&partnerID=8YFLogxK
M3 - Article
C2 - 10498160
AN - SCOPUS:0032879269
VL - 92
SP - 866
EP - 870
JO - Southern Medical Journal
JF - Southern Medical Journal
SN - 0038-4348
IS - 9
ER -