Long-term diuretic therapy in hypertensive patients

Effects on serum homocysteine, vitamin B6, vitamin B12, and red blood cell folate concentrations

Lee E. Morrow, Edwin W. Grimsley

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background. The effects of chronic diuretic use on serum homocysteine and its metabolic cofactors vitamin B6, vitamin B12, and red blood cell (RBC) folate have not been well studied. Methods. Blood samples from 17 hypertensive patients receiving long-term diuretic therapy and 17 hypertensive patients not taking diuretics were analyzed for serum homocysteine, vitamin B6, vitamin B12, and RBC folate. Results. The mean serum homocysteine concentration for patients taking diuretics (17.87 ± 1.72 μmol/L) was significantly higher than the mean serum homocysteine concentration for patients not taking diuretics (10.31 ± 0.99 μmol/L). The mean RBC folate concentration for patients taking diuretics (281.01 ± 17.56 ng/mL) was significantly lower than the mean RBC folate concentration for patients not taking diuretics (430.85 ± 28.58 ng/mL). Serum vitamin B6 and vitamin B12 concentrations were not significantly different between the two groups. Conclusions. Chronic diuretic use is associated with a significant increase in serum homocysteine concentration, a significant decrease in RBC folate concentration, and no significant change in concentrations of vitamins B6 and B12.

Original languageEnglish
Pages (from-to)866-870
Number of pages5
JournalSouthern Medical Journal
Volume92
Issue number9
StatePublished - Sep 1999
Externally publishedYes

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Vitamin B 6
Homocysteine
Vitamin B 12
Folic Acid
Diuretics
Erythrocytes
Serum
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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title = "Long-term diuretic therapy in hypertensive patients: Effects on serum homocysteine, vitamin B6, vitamin B12, and red blood cell folate concentrations",
abstract = "Background. The effects of chronic diuretic use on serum homocysteine and its metabolic cofactors vitamin B6, vitamin B12, and red blood cell (RBC) folate have not been well studied. Methods. Blood samples from 17 hypertensive patients receiving long-term diuretic therapy and 17 hypertensive patients not taking diuretics were analyzed for serum homocysteine, vitamin B6, vitamin B12, and RBC folate. Results. The mean serum homocysteine concentration for patients taking diuretics (17.87 ± 1.72 μmol/L) was significantly higher than the mean serum homocysteine concentration for patients not taking diuretics (10.31 ± 0.99 μmol/L). The mean RBC folate concentration for patients taking diuretics (281.01 ± 17.56 ng/mL) was significantly lower than the mean RBC folate concentration for patients not taking diuretics (430.85 ± 28.58 ng/mL). Serum vitamin B6 and vitamin B12 concentrations were not significantly different between the two groups. Conclusions. Chronic diuretic use is associated with a significant increase in serum homocysteine concentration, a significant decrease in RBC folate concentration, and no significant change in concentrations of vitamins B6 and B12.",
author = "Morrow, {Lee E.} and Grimsley, {Edwin W.}",
year = "1999",
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language = "English",
volume = "92",
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TY - JOUR

T1 - Long-term diuretic therapy in hypertensive patients

T2 - Effects on serum homocysteine, vitamin B6, vitamin B12, and red blood cell folate concentrations

AU - Morrow, Lee E.

AU - Grimsley, Edwin W.

PY - 1999/9

Y1 - 1999/9

N2 - Background. The effects of chronic diuretic use on serum homocysteine and its metabolic cofactors vitamin B6, vitamin B12, and red blood cell (RBC) folate have not been well studied. Methods. Blood samples from 17 hypertensive patients receiving long-term diuretic therapy and 17 hypertensive patients not taking diuretics were analyzed for serum homocysteine, vitamin B6, vitamin B12, and RBC folate. Results. The mean serum homocysteine concentration for patients taking diuretics (17.87 ± 1.72 μmol/L) was significantly higher than the mean serum homocysteine concentration for patients not taking diuretics (10.31 ± 0.99 μmol/L). The mean RBC folate concentration for patients taking diuretics (281.01 ± 17.56 ng/mL) was significantly lower than the mean RBC folate concentration for patients not taking diuretics (430.85 ± 28.58 ng/mL). Serum vitamin B6 and vitamin B12 concentrations were not significantly different between the two groups. Conclusions. Chronic diuretic use is associated with a significant increase in serum homocysteine concentration, a significant decrease in RBC folate concentration, and no significant change in concentrations of vitamins B6 and B12.

AB - Background. The effects of chronic diuretic use on serum homocysteine and its metabolic cofactors vitamin B6, vitamin B12, and red blood cell (RBC) folate have not been well studied. Methods. Blood samples from 17 hypertensive patients receiving long-term diuretic therapy and 17 hypertensive patients not taking diuretics were analyzed for serum homocysteine, vitamin B6, vitamin B12, and RBC folate. Results. The mean serum homocysteine concentration for patients taking diuretics (17.87 ± 1.72 μmol/L) was significantly higher than the mean serum homocysteine concentration for patients not taking diuretics (10.31 ± 0.99 μmol/L). The mean RBC folate concentration for patients taking diuretics (281.01 ± 17.56 ng/mL) was significantly lower than the mean RBC folate concentration for patients not taking diuretics (430.85 ± 28.58 ng/mL). Serum vitamin B6 and vitamin B12 concentrations were not significantly different between the two groups. Conclusions. Chronic diuretic use is associated with a significant increase in serum homocysteine concentration, a significant decrease in RBC folate concentration, and no significant change in concentrations of vitamins B6 and B12.

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VL - 92

SP - 866

EP - 870

JO - Southern Medical Journal

JF - Southern Medical Journal

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