Abstract
This study determined the effects of nicotine on serum concentrations of several calciotropic hormones, and bone formation and resorption end-points in 7 month old, adult female rats. Animals were administered either saline (n= 9/group), low dose nicotine at 3.0 mg/kg/day (n=10/group) or high dose nicotine at 4.5 mg/kg/day (n=11/group) by subcutaneous osmotic minipumps. At the end of a three months treatment period, serum concentrations of calcium, phosphorus, parathyroid hormone, calcitonin, 25-hydroxyvitamin D and 1,25- dihydroxyvitamin D were determined. Femora, tibiae, and lumbar vertebrae (3- 5) were collected and bone parameters evaluated included mineral density and content (femora and vertebrae), strength (femora and vertebrae) and histomorphometry (tibiae). Animals given nicotine had significantly lower levels of 25-hydroxyvitamin D than controls [20.8±1.4 ng/ml for the low dose group and 20.7±1.0 ng/ml for the high dose group versus 27.6±1.3 ng/ml for the control group (mean±S.E.M.), P2 versus 6.2±0.2 mm2, P
| Original language | English |
|---|---|
| Pages (from-to) | 181-187 |
| Number of pages | 7 |
| Journal | Pharmacology and Toxicology |
| Volume | 85 |
| Issue number | 4 |
| State | Published - 1999 |
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All Science Journal Classification (ASJC) codes
- Pharmacology
- Toxicology
- Health, Toxicology and Mutagenesis
Cite this
Long-term effects of nicotine on bone and calciotropic hormones in adult female rats. / Fung, Yiu K.; Iwaniec, Urszula; Cullen, Diane M.; Akhter, Mohammed P.; Haven, Mary C.; Timmins, Patrick.
In: Pharmacology and Toxicology, Vol. 85, No. 4, 1999, p. 181-187.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Long-term effects of nicotine on bone and calciotropic hormones in adult female rats
AU - Fung, Yiu K.
AU - Iwaniec, Urszula
AU - Cullen, Diane M.
AU - Akhter, Mohammed P.
AU - Haven, Mary C.
AU - Timmins, Patrick
PY - 1999
Y1 - 1999
N2 - This study determined the effects of nicotine on serum concentrations of several calciotropic hormones, and bone formation and resorption end-points in 7 month old, adult female rats. Animals were administered either saline (n= 9/group), low dose nicotine at 3.0 mg/kg/day (n=10/group) or high dose nicotine at 4.5 mg/kg/day (n=11/group) by subcutaneous osmotic minipumps. At the end of a three months treatment period, serum concentrations of calcium, phosphorus, parathyroid hormone, calcitonin, 25-hydroxyvitamin D and 1,25- dihydroxyvitamin D were determined. Femora, tibiae, and lumbar vertebrae (3- 5) were collected and bone parameters evaluated included mineral density and content (femora and vertebrae), strength (femora and vertebrae) and histomorphometry (tibiae). Animals given nicotine had significantly lower levels of 25-hydroxyvitamin D than controls [20.8±1.4 ng/ml for the low dose group and 20.7±1.0 ng/ml for the high dose group versus 27.6±1.3 ng/ml for the control group (mean±S.E.M.), P2 versus 6.2±0.2 mm2, P
AB - This study determined the effects of nicotine on serum concentrations of several calciotropic hormones, and bone formation and resorption end-points in 7 month old, adult female rats. Animals were administered either saline (n= 9/group), low dose nicotine at 3.0 mg/kg/day (n=10/group) or high dose nicotine at 4.5 mg/kg/day (n=11/group) by subcutaneous osmotic minipumps. At the end of a three months treatment period, serum concentrations of calcium, phosphorus, parathyroid hormone, calcitonin, 25-hydroxyvitamin D and 1,25- dihydroxyvitamin D were determined. Femora, tibiae, and lumbar vertebrae (3- 5) were collected and bone parameters evaluated included mineral density and content (femora and vertebrae), strength (femora and vertebrae) and histomorphometry (tibiae). Animals given nicotine had significantly lower levels of 25-hydroxyvitamin D than controls [20.8±1.4 ng/ml for the low dose group and 20.7±1.0 ng/ml for the high dose group versus 27.6±1.3 ng/ml for the control group (mean±S.E.M.), P2 versus 6.2±0.2 mm2, P
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UR - http://www.scopus.com/inward/citedby.url?scp=0032873329&partnerID=8YFLogxK
M3 - Article
C2 - 10563517
AN - SCOPUS:0032873329
VL - 85
SP - 181
EP - 187
JO - Basic and Clinical Pharmacology and Toxicology
JF - Basic and Clinical Pharmacology and Toxicology
SN - 1742-7835
IS - 4
ER -