Long-term effects of nicotine on bone and calciotropic hormones in adult female rats

Yiu K. Fung, Urszula Iwaniec, Diane M. Cullen, Mohammed P. Akhter, Mary C. Haven, Patrick Timmins

Research output: Contribution to journalArticle

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Abstract

This study determined the effects of nicotine on serum concentrations of several calciotropic hormones, and bone formation and resorption end-points in 7 month old, adult female rats. Animals were administered either saline (n= 9/group), low dose nicotine at 3.0 mg/kg/day (n=10/group) or high dose nicotine at 4.5 mg/kg/day (n=11/group) by subcutaneous osmotic minipumps. At the end of a three months treatment period, serum concentrations of calcium, phosphorus, parathyroid hormone, calcitonin, 25-hydroxyvitamin D and 1,25- dihydroxyvitamin D were determined. Femora, tibiae, and lumbar vertebrae (3- 5) were collected and bone parameters evaluated included mineral density and content (femora and vertebrae), strength (femora and vertebrae) and histomorphometry (tibiae). Animals given nicotine had significantly lower levels of 25-hydroxyvitamin D than controls [20.8±1.4 ng/ml for the low dose group and 20.7±1.0 ng/ml for the high dose group versus 27.6±1.3 ng/ml for the control group (mean±S.E.M.), P2 versus 6.2±0.2 mm2, P

Original languageEnglish
Pages (from-to)181-187
Number of pages7
JournalPharmacology and Toxicology
Volume85
Issue number4
StatePublished - 1999

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Nicotine
Rats
Bone
Hormones
Femur
Bone and Bones
Tibia
Animals
Spine
Lumbar Vertebrae
Calcitonin
Bone Resorption
Parathyroid Hormone
Serum
Osteogenesis
Phosphorus
Minerals
Calcium
Control Groups
25-hydroxyvitamin D

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Fung, Y. K., Iwaniec, U., Cullen, D. M., Akhter, M. P., Haven, M. C., & Timmins, P. (1999). Long-term effects of nicotine on bone and calciotropic hormones in adult female rats. Pharmacology and Toxicology, 85(4), 181-187.

Long-term effects of nicotine on bone and calciotropic hormones in adult female rats. / Fung, Yiu K.; Iwaniec, Urszula; Cullen, Diane M.; Akhter, Mohammed P.; Haven, Mary C.; Timmins, Patrick.

In: Pharmacology and Toxicology, Vol. 85, No. 4, 1999, p. 181-187.

Research output: Contribution to journalArticle

Fung, YK, Iwaniec, U, Cullen, DM, Akhter, MP, Haven, MC & Timmins, P 1999, 'Long-term effects of nicotine on bone and calciotropic hormones in adult female rats', Pharmacology and Toxicology, vol. 85, no. 4, pp. 181-187.
Fung, Yiu K. ; Iwaniec, Urszula ; Cullen, Diane M. ; Akhter, Mohammed P. ; Haven, Mary C. ; Timmins, Patrick. / Long-term effects of nicotine on bone and calciotropic hormones in adult female rats. In: Pharmacology and Toxicology. 1999 ; Vol. 85, No. 4. pp. 181-187.
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