Longitudinal changes in bronchial hyperresponsiveness in asthmatic and previously asthmatic children

P. J. Radford, R. J. Hopp, R. E. Biven, J. A. Degan, Againdra K. Bewtra, R. G. Townley

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

To determine if nonspecific bronchial hyperresponsiveness is present to the same degree in previously asthmatic children compared with currently asthmatic children, a longitudinal study was conducted. On the basis of a standardized respiratory questionnaire, 139 children from asthmatic families, between the ages of 6 and 21 years, were identified. Subjects had skin tests, a serum IgE level, and a methacholine challenge test. IgE and skin tests demonstrated atopy in both the previously and currently asthmatic children, which persisted over time. Bronchial hyperresponsiveness within the asthmatic children was not significantly different between visits. Previously asthmatic children did have significantly decreased airway hyperresponsiveness over time. Age did not affect the results of the bronchial hyperresponsiveness in the currently asthmatic children. Currently asthmatic children, however, were significantly more atopic when compared with previously asthmatic children at their initial evaluation. Currently asthmatic children were also more bronchial responsive and remained so over time. Bronchial hyperresponsiveness is persistent in children with current asthma symptoms.

Original languageEnglish
Pages (from-to)624-629
Number of pages6
JournalChest
Volume101
Issue number3
StatePublished - 1992
Externally publishedYes

Fingerprint

Skin Tests
Immunoglobulin E
Methacholine Chloride
Longitudinal Studies
Asthma
Serum
Surveys and Questionnaires

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

Cite this

Radford, P. J., Hopp, R. J., Biven, R. E., Degan, J. A., Bewtra, A. K., & Townley, R. G. (1992). Longitudinal changes in bronchial hyperresponsiveness in asthmatic and previously asthmatic children. Chest, 101(3), 624-629.

Longitudinal changes in bronchial hyperresponsiveness in asthmatic and previously asthmatic children. / Radford, P. J.; Hopp, R. J.; Biven, R. E.; Degan, J. A.; Bewtra, Againdra K.; Townley, R. G.

In: Chest, Vol. 101, No. 3, 1992, p. 624-629.

Research output: Contribution to journalArticle

Radford, PJ, Hopp, RJ, Biven, RE, Degan, JA, Bewtra, AK & Townley, RG 1992, 'Longitudinal changes in bronchial hyperresponsiveness in asthmatic and previously asthmatic children', Chest, vol. 101, no. 3, pp. 624-629.
Radford, P. J. ; Hopp, R. J. ; Biven, R. E. ; Degan, J. A. ; Bewtra, Againdra K. ; Townley, R. G. / Longitudinal changes in bronchial hyperresponsiveness in asthmatic and previously asthmatic children. In: Chest. 1992 ; Vol. 101, No. 3. pp. 624-629.
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