Low serum IgA in a familial ovarian cancer aggregate

Guy S. Schuelke, Henry T. Lynch, Jane F. Lynch, Pamela R. Fain, Edward A. Chaperon

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9 Scopus citations


Low serum IgA levels were found to segregate in a sufficient number of individuals from a familial ovarian carcinoma aggregate to suggest that this may be a genetically determined immune defect etiologically integral to cancer susceptibility in this family. The putative role of IgA in pathogenesis remains elusive. Cancer-prone families should be thoroughly investigated for further elucidation of these phenomena.

Original languageEnglish (US)
Pages (from-to)231-236
Number of pages6
JournalCancer Genetics and Cytogenetics
Issue number3
StatePublished - Jul 1982

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Cancer Research

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    Schuelke, G. S., Lynch, H. T., Lynch, J. F., Fain, P. R., & Chaperon, E. A. (1982). Low serum IgA in a familial ovarian cancer aggregate. Cancer Genetics and Cytogenetics, 6(3), 231-236. https://doi.org/10.1016/0165-4608(82)90060-7