Low serum IgA levels were found to segregate in a sufficient number of individuals from a familial ovarian carcinoma aggregate to suggest that this may be a genetically determined immune defect etiologically integral to cancer susceptibility in this family. The putative role of IgA in pathogenesis remains elusive. Cancer-prone families should be thoroughly investigated for further elucidation of these phenomena.
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cancer Research